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UniProtKB - A0A1W2PRS1 (A0A1W2PRS1_HUMAN)
Protein
Submitted name:
Lysosome membrane protein 2
Gene
SCARB2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Lysosome membrane protein 2Imported |
Gene namesi | Name:SCARB2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1665, SCARB2 |
VEuPathDBi | HostDB:ENSG00000138760 |
Subcellular locationi
Lysosome
- lysosome Source: InterPro
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 479 – 499 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_5012958432 | 20 – 519 | Sequence analysisAdd BLAST | 500 |
Keywords - PTMi
GlycoproteinARBA annotationProteomic databases
PeptideAtlasi | A0A1W2PRS1 |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the CD36 family.ARBA annotation
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000153372 |
Family and domain databases
InterProi | View protein in InterPro IPR002159, CD36_fam IPR005429, LimpII |
PANTHERi | PTHR11923, PTHR11923, 2 hits |
Pfami | View protein in Pfam PF01130, CD36, 1 hit |
PRINTSi | PR01609, CD36FAMILY PR01611, LIMPII |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 13 potential isoforms that are computationally mapped.Show allAlign All
A0A1W2PRS1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XAGTLSLLLL VTSVTLLVAR VFQKAVDQSI EKKIVLRNGT EAFDSWEKPP
60 70 80 90 100
LPVYTQFYFF NVTNPEEILR GETPRVEEVG PYTYRELRNK ANIQFGDNGT
110 120 130 140 150
TISAVSNKAY VFERDQSVGD PKIDLIRTLN IPVLTGSCSV AQAGVQSVAP
160 170 180 190 200
SQLTEASTSW APGILLCRPG TPGVNHCSWA GPTVIEWSQV HFLREIIEAM
210 220 230 240 250
LKAYQQKLFV THTVDELLWG YKDEILSLIH VFRPDISPYF GLFYEKNGTN
260 270 280 290 300
DGDYVFLTGE DSYLNFTKIV EWNGKTSLDW WITDKCNMIN GTDGDSFHPL
310 320 330 340 350
ITKDEVLYVF PSDFCRSVYI TFSDYESVQG LPAFRYKVPA EILANTSDNA
360 370 380 390 400
GFCIPEGNCL GSGVLNVSIC KNGAPIIMSF PHFYQADERF VSAIEGMHPN
410 420 430 440 450
QEDHETFVDI NPLTGIILKA AKRFQINIYV KKLDDFVETG DIRTMVFPVM
460 470 480 490 500
YLNESVHIDK ETASRLKSMI NTTLIITNIP YIIMALGVFF GLVFTWLACK
510
GQGSMDEGTA DERAPLIRT
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ14108 | SCRB2_HUMAN | Lysosome membrane protein 2 | SCARB2 CD36L2, LIMP2, LIMPII | 478 | Annotation score: | ||
A0A1W2PPU6 | A0A1W2PPU6_HUMAN | Lysosome membrane protein 2 | SCARB2 | 438 | Annotation score: | ||
A0A1W2PQB7 | A0A1W2PQB7_HUMAN | Lysosome membrane protein 2 | SCARB2 | 470 | Annotation score: | ||
A0A1W2PS43 | A0A1W2PS43_HUMAN | Lysosome membrane protein 2 | SCARB2 | 475 | Annotation score: | ||
D6RDG0 | D6RDG0_HUMAN | Lysosome membrane protein 2 | SCARB2 | 106 | Annotation score: | ||
A0A1W2PQR6 | A0A1W2PQR6_HUMAN | Lysosome membrane protein 2 | SCARB2 | 449 | Annotation score: | ||
A0A1W2PS70 | A0A1W2PS70_HUMAN | Lysosome membrane protein 2 | SCARB2 | 141 | Annotation score: | ||
A0A1W2PPX5 | A0A1W2PPX5_HUMAN | Lysosome membrane protein 2 | SCARB2 | 432 | Annotation score: | ||
A0A1W2PSE4 | A0A1W2PSE4_HUMAN | Lysosome membrane protein 2 | SCARB2 | 206 | Annotation score: | ||
A0A1W2PNX7 | A0A1W2PNX7_HUMAN | Lysosome membrane protein 2 | SCARB2 | 145 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC034139 Genomic DNA No translation available. AC110795 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000640634; ENSP00000492737; ENSG00000138760 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC034139 Genomic DNA No translation available. AC110795 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A1W2PRS1 |
Protocols and materials databases
Antibodypediai | 3014, 424 antibodies from 38 providers |
Genome annotation databases
Ensembli | ENST00000640634; ENSP00000492737; ENSG00000138760 |
Organism-specific databases
HGNCi | HGNC:1665, SCARB2 |
OpenTargetsi | ENSG00000138760 |
VEuPathDBi | HostDB:ENSG00000138760 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000153372 |
Miscellaneous databases
ChiTaRSi | SCARB2, human |
Gene expression databases
ExpressionAtlasi | A0A1W2PRS1, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR002159, CD36_fam IPR005429, LimpII |
PANTHERi | PTHR11923, PTHR11923, 2 hits |
Pfami | View protein in Pfam PF01130, CD36, 1 hit |
PRINTSi | PR01609, CD36FAMILY PR01611, LIMPII |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A1W2PRS1_HUMAN | |
Accessioni | A0A1W2PRS1Primary (citable) accession number: A0A1W2PRS1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 7, 2017 |
Last sequence update: | June 7, 2017 | |
Last modified: | January 19, 2022 | |
This is version 24 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |