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UniProtKB - A0A1W2PRA7 (A0A1W2PRA7_HUMAN)
Protein
BK channel
Gene
KCNMA1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- large conductance calcium-activated potassium channel activity Source: InterPro
Keywordsi
Molecular function | Ion channel, Potassium channelARBA annotation |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Names & Taxonomyi
Protein namesi | Recommended name: BK channelARBA annotationAlternative name(s): BKCA alphaARBA annotation Calcium-activated potassium channel subunit alpha-1ARBA annotation Calcium-activated potassium channel, subfamily M subunit alpha-1ARBA annotation K(VCA)alphaARBA annotation KCa1.1ARBA annotation Maxi K channelARBA annotation Slo-alphaARBA annotation Slo1ARBA annotation Slowpoke homologARBA annotation |
Gene namesi | Name:KCNMA1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6284, KCNMA1 |
VEuPathDBi | HostDB:ENSG00000156113 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-KW
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 53 – 71 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 91 – 109 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 174 – 195 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 210 – 229 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 241 – 259 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembraneStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 56 – 265 | Ion_transInterPro annotationAdd BLAST | 210 | |
Domaini | 357 – 444 | BK_channel_aInterPro annotationAdd BLAST | 88 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 514 – 542 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 719 – 742 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 939 – 964 | DisorderedSequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 519 – 537 | Polar residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily. [View classification]ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000154935 |
Family and domain databases
InterProi | View protein in InterPro IPR024939, Ca-act_K_channel_Slo-1 IPR005821, Ion_trans_dom IPR003929, K_chnl_BK_asu |
PANTHERi | PTHR10027:SF28, PTHR10027:SF28, 3 hits |
Pfami | View protein in Pfam PF03493, BK_channel_a, 1 hit PF00520, Ion_trans, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 68 potential isoforms that are computationally mapped.Show allAlign All
A0A1W2PRA7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XAQKINNGSS QADGTLKPVD EKEEAVAAEV GWMTSVKDWA GVMISAQTLT
60 70 80 90 100
GRVLVVLVFA LSIGALVIYF IDSSNPIESC QNFYKDFTLQ IDMAFNVFFL
110 120 130 140 150
LYFGLRFIAA NDKLWFWLEV NSVVDFFTVP PVFVSVYLNR SWLGLRFLRA
160 170 180 190 200
LRLIQFSEIL QFLNILKTSN SIKLVNLLSI FISTWLTAAG FIHLVENSGD
210 220 230 240 250
PWENFQNNQA LTYWECVYLL MVTMSTVGYG DVYAKTTLGR LFMVFFILGG
260 270 280 290 300
LAMFASYVPE IIELIGNRKK YGGSYSAVSG RKHIVVCGHI TLESVSNFLK
310 320 330 340 350
DFLHKDRDDV NVEIVFLHKV ISIKNYHPKI RIITQMLQYH NKAHLLNIPS
360 370 380 390 400
WNWKEGDDAI CLAELKLGFI AQSCLAQGLS TMLANLFSMR SFIKIEEDTW
410 420 430 440 450
QKYYLEGVSN EMYTEYLSSA FVGLSFPTVC ELCFVKLKLL MIAIEYKSAN
460 470 480 490 500
RESRILINPG NHLKIQEGTL GFFIASDAKE VKRAFFYCKA CHDDITDPKR
510 520 530 540 550
IKKCGCKRLE DEQPSTLSPK KKQRNGGMRN SPNTSPKLMR HDPLLIPGND
560 570 580 590 600
QIDNMDSNVK KYDSTGMFHW CAPKEIEKVI LTRSEAAMTV LSGHVVVCIF
610 620 630 640 650
GDVSSALIGL RNLVMPLRAS NFHYHELKHI VFVGSIEYLK REWETLHNFP
660 670 680 690 700
KVSILPGTPL SRADLRAVNI NLCDMCVILS ANQNNIDDTS LQDKECILAS
710 720 730 740 750
LNIKSMQFDD SIGVLQANSQ GFTPPGMDRS SPDNSPVHGM LRQPSITTGV
760 770 780 790 800
NIPIITELVN DTNVQFLDQD DDDDPDTELY LTQPFACGTA FAVSVLDSLM
810 820 830 840 850
SATYFNDNIL TLIRTLVTGG ATPELEALIA EENALRGGYS TPQTLANRDR
860 870 880 890 900
CRVAQLALLD GPFADLGDGG CYGDLFCKAL KTYNMLCFGI YRLRDAHLST
910 920 930 940 950
PSQCTKRYVI TNPPYEFELV PTDLIFCLMQ FDHNAGQSRA SLSHSSHSSQ
960
SSSKKSSSVH SIPS
Computationally mapped potential isoform sequencesi
There are 68 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ12791 | KCMA1_HUMAN | Calcium-activated potassium channel... | KCNMA1 KCNMA, SLO | 1,236 | Annotation score: | ||
A0A1W2PQK5 | A0A1W2PQK5_HUMAN | BK channel | KCNMA1 | 1,177 | Annotation score: | ||
A0A1W2PP94 | A0A1W2PP94_HUMAN | BK channel | KCNMA1 | 1,181 | Annotation score: | ||
A0A1W2PPY5 | A0A1W2PPY5_HUMAN | BK channel | KCNMA1 | 1,230 | Annotation score: | ||
A0A1W2PQU4 | A0A1W2PQU4_HUMAN | BK channel | KCNMA1 | 1,178 | Annotation score: | ||
A0A1W2PR56 | A0A1W2PR56_HUMAN | BK channel | KCNMA1 | 1,212 | Annotation score: | ||
A0A1W2PR62 | A0A1W2PR62_HUMAN | BK channel | KCNMA1 | 1,236 | Annotation score: | ||
A0A1W2PRN5 | A0A1W2PRN5_HUMAN | BK channel | KCNMA1 | 1,239 | Annotation score: | ||
A0A1W2PSD3 | A0A1W2PSD3_HUMAN | BK channel | KCNMA1 | 1,178 | Annotation score: | ||
B7ZMF5 | B7ZMF5_HUMAN | BK channel | KCNMA1 | 1,208 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 964 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011439 Genomic DNA No translation available. AC021032 Genomic DNA No translation available. AC067745 Genomic DNA No translation available. AL157833 Genomic DNA No translation available. AL607069 Genomic DNA No translation available. AL627447 Genomic DNA No translation available. AL731556 Genomic DNA No translation available. AL731560 Genomic DNA No translation available. AL731575 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000640353; ENSP00000492153; ENSG00000156113 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011439 Genomic DNA No translation available. AC021032 Genomic DNA No translation available. AC067745 Genomic DNA No translation available. AL157833 Genomic DNA No translation available. AL607069 Genomic DNA No translation available. AL627447 Genomic DNA No translation available. AL731556 Genomic DNA No translation available. AL731560 Genomic DNA No translation available. AL731575 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A1W2PRA7 |
Protocols and materials databases
Antibodypediai | 29733, 342 antibodies from 37 providers |
Genome annotation databases
Ensembli | ENST00000640353; ENSP00000492153; ENSG00000156113 |
Organism-specific databases
HGNCi | HGNC:6284, KCNMA1 |
OpenTargetsi | ENSG00000156113 |
VEuPathDBi | HostDB:ENSG00000156113 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154935 |
Miscellaneous databases
ChiTaRSi | KCNMA1, human |
Gene expression databases
ExpressionAtlasi | A0A1W2PRA7, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR024939, Ca-act_K_channel_Slo-1 IPR005821, Ion_trans_dom IPR003929, K_chnl_BK_asu |
PANTHERi | PTHR10027:SF28, PTHR10027:SF28, 3 hits |
Pfami | View protein in Pfam PF03493, BK_channel_a, 1 hit PF00520, Ion_trans, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A1W2PRA7_HUMAN | |
Accessioni | A0A1W2PRA7Primary (citable) accession number: A0A1W2PRA7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 7, 2017 |
Last sequence update: | June 7, 2017 | |
Last modified: | January 19, 2022 | |
This is version 25 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |