UniProtKB - A0A1W2PQQ0 (A0A1W2PQQ0_HUMAN)
Protein
Submitted name:
Wilms tumor protein
Gene
WT1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | DNA-bindingARBA annotation, RNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Wilms tumor proteinImported |
Gene namesi | Name:WT1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12796, WT1 |
Subcellular locationi
Nucleus
- Nucleus speckle ARBA annotation
Other locations
- Cytoplasm ARBA annotation
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear speck Source: UniProtKB-SubCell
- nucleoplasm Source: HPA
Keywords - Cellular componenti
CytoplasmARBA annotation, NucleusARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 379 – 408 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 409 – 438 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 439 – 466 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 470 – 499 | C2H2-typeInterPro annotationAdd BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 14 – 42 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 55 – 75 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 121 – 157 | DisorderedSequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 14 – 32 | PolarSequence analysisAdd BLAST | 19 | |
Compositional biasi | 126 – 145 | Pro-richSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the EGR C2H2-type zinc-finger protein family.ARBA annotation
Keywords - Domaini
RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationPhylogenomic databases
GeneTreei | ENSGT00940000156734 |
Family and domain databases
InterProi | View protein in InterPro IPR017987, Wilms_tumour IPR000976, Wilms_tumour_N IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23235:SF49, PTHR23235:SF49, 1 hit |
Pfami | View protein in Pfam PF02165, WT1, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
A0A1W2PQQ0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
LDFLLLQDPA STCVPEPASQ HTLRSGPGCL QQPEQQGVRD PGGIWAKLGA
60 70 80 90 100
AEASAERLQG RRSRGASGSE PQQMGSDVRD LNALLPAVPS LGGGGGCALP
110 120 130 140 150
VSGAAQWAPV LDFAPPGASA YGSLGGPAPP PAPPPPPPPP PHSFIKQEPS
160 170 180 190 200
WGGAEPHEEQ CLSAFTVHFS GQFTGTAGAC RYGPFGPPPP SQASSGQARM
210 220 230 240 250
FPNAPYLPSC LESQPAIRNQ GYSTVTFDGT PSYGHTPSHH AAQFPNHSFK
260 270 280 290 300
HEDPMGQQGS LGEQQYSVPP PVYGCHTPTD SCTGSQALLL RTPYSSDNLY
310 320 330 340 350
QMTSQLECMT WNQMNLGATL KGHSTGYESD NHTTPILCGA QYRIHTHGVF
360 370 380 390 400
RGIQDVRRVP GVAPTLVRSA SETSEKRPFM CAYPGCNKRY FKLSHLQMHS
410 420 430 440 450
RKHTGEKPYQ CDFKDCERRF SRSDQLKRHQ RRHTGVKPFQ CKTCQRKFSR
460 470 480 490 500
SDHLKTHTRT HTGKTSEKPF SCRWPSCQKK FARSDELVRH HNMHQRNMTK
LQLAL
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP19544 | WT1_HUMAN | Wilms tumor protein | WT1 | 449 | Annotation score: | ||
H0Y7K5 | H0Y7K5_HUMAN | Wilms tumor protein | WT1 | 519 | Annotation score: | ||
J3KNN9 | J3KNN9_HUMAN | Wilms tumor protein | WT1 | 502 | Annotation score: | ||
A0A0A0MT54 | A0A0A0MT54_HUMAN | Wilms tumor protein | WT1 | 522 | Annotation score: | ||
A0A1W2PR07 | A0A1W2PR07_HUMAN | Wilms tumor protein | WT1 | 297 | Annotation score: | ||
H0YED9 | H0YED9_HUMAN | Wilms tumor protein | WT1 | 178 | Annotation score: | ||
H0Y3F0 | H0Y3F0_HUMAN | Wilms tumor protein | WT1 | 322 | Annotation score: | ||
A0A494C0I9 | A0A494C0I9_HUMAN | Wilms tumor protein | WT1 | 43 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL049692 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000639563; ENSP00000492269; ENSG00000184937 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL049692 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A0A1W2PQQ0 |
Protocols and materials databases
Antibodypediai | 3523, 1083 antibodies |
Genome annotation databases
Ensembli | ENST00000639563; ENSP00000492269; ENSG00000184937 |
Organism-specific databases
HGNCi | HGNC:12796, WT1 |
OpenTargetsi | ENSG00000184937 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156734 |
Miscellaneous databases
ChiTaRSi | WT1, human |
GenomeRNAii | 7490 |
Gene expression databases
ExpressionAtlasi | A0A1W2PQQ0, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR017987, Wilms_tumour IPR000976, Wilms_tumour_N IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23235:SF49, PTHR23235:SF49, 1 hit |
Pfami | View protein in Pfam PF02165, WT1, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A1W2PQQ0_HUMAN | |
Accessioni | A0A1W2PQQ0Primary (citable) accession number: A0A1W2PQQ0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 7, 2017 |
Last sequence update: | June 5, 2019 | |
Last modified: | February 10, 2021 | |
This is version 26 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |