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Protein
Submitted name:

Calcium-activated potassium channel subunit alpha-1

Gene

KCNMA1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channelSAAS annotation, Voltage-gated channelSAAS annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Submitted name:
Calcium-activated potassium channel subunit alpha-1Imported
Gene namesi
Name:KCNMA1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:6284 KCNMA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei86 – 108HelicalSequence analysisAdd BLAST23
Transmembranei179 – 197HelicalSequence analysisAdd BLAST19
Transmembranei217 – 235HelicalSequence analysisAdd BLAST19
Transmembranei300 – 321HelicalSequence analysisAdd BLAST22
Transmembranei336 – 355HelicalSequence analysisAdd BLAST20
Transmembranei367 – 385HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156113

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A1W2PPZ1

Expressioni

Gene expression databases

ExpressionAtlasiA0A1W2PPZ1 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 391Ion_transInterPro annotationAdd BLAST210

Sequence similaritiesi

Belongs to the potassium channel family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00530000063026

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR024939 Ca-act_K_channel_Slo-1
IPR005821 Ion_trans_dom
IPR003929 K_chnl_BK_asu
IPR036291 NAD(P)-bd_dom_sf
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10027:SF28 PTHR10027:SF28, 1 hit
PfamiView protein in Pfam
PF03493 BK_channel_a, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
SUPFAMiSSF51735 SSF51735, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 69 potential isoforms that are computationally mapped.iShow all

A0A1W2PPZ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANGGGGGGG SSGGGGGGGG SSLRMSSNIH ANHLSLDASS SSSSSSSSSS
60 70 80 90 100
SSSSSSSSSS VHEPKMDALI IPVTMEVPCD SRGQRMWWAF LASSMVTFFG
110 120 130 140 150
GLFIILLWRT LKYLWTVCCH CGGKTKEAQK INNGSSQADG TLKPVDEKEE
160 170 180 190 200
AVAAEVGWMT SVKDWAGVMI SAQTLTGRVL VVLVFALSIG ALVIYFIDSS
210 220 230 240 250
NPIESCQNFY KDFTLQIDMA FNVFFLLYFG LRFIAANDKL WFWLEVNSVV
260 270 280 290 300
DFFTVPPVFV SVYLNRSWLG LRFLRALRLI QFSEILQFLN ILKTSNSIKL
310 320 330 340 350
VNLLSIFIST WLTAAGFIHL VENSGDPWEN FQNNQALTYW ECVYLLMVTM
360 370 380 390 400
STVGYGDVYA KTTLGRLFMV FFILGGLAMF ASYVPEIIEL IGNRKKYGGS
410 420 430 440 450
YSAVSGRKHI VVCGHITLES VSNFLKDFLH KDRDDVNVEI VFLHNISPNL
460 470 480 490 500
ELEALFKRHF TQVEFYQGSV LNPHDLARVK IESADACLIL ANKYCADPDA
510 520 530 540 550
EDASNIMRVI SIKNYHPKIR IITQMLQYHN KAHLLNIPSW NWKEGDDAIC
560 570 580 590 600
LAELKLGFIA QSCLAQGLST MLANLFSMRS FIKIEEDTWQ KYYLEGVSNE
610 620 630 640 650
MYTEYLSSAF VGLSFPTVCE LCFVKLKLLM IAIEYKSANR ESRSRKRILI
660 670 680 690 700
NPGNHLKIQE GTLGFFIASD AKEVKRAFFY CKACHDDITD PKRIKKCGCK
710 720 730 740 750
RLIYFEDEQP STLSPKKKQR NGGMRNSPNT SPKLMRHDPL LIPGNDQIDN
760 770 780 790 800
MDSNVKKYDS TGMFHWCAPK EIEKVILTRS EAAMTVLSGH VVVCIFGDVS
810 820 830 840 850
SALIGLRNLV MPLRASNFHY HELKHIVFVG SIEYLKREWE TLHNFPKVSI
860 870 880 890 900
LPGTPLSRAD LRAVNINLCD MCVILSANQN NIDDTSLQDK ECILASLNIK
910 920 930 940 950
SMQFDDSIGV LQANSQGFTP PGMDRSSPDN SPVHGMLRQP SITTGVNIPI
960 970 980 990 1000
ITELVNDTNV QFLDQDDDDD PDTELYLTQP FACGTAFAVS VLDSLMSATY
1010 1020 1030 1040 1050
FNDNILTLIR TLVTGGATPE LEALIAEENA LRGGYSTPQT LANRDRCRVA
1060 1070 1080 1090 1100
QLALLDGPFA DLGDGGCYGD LFCKALKTYN MLCFGIYRLR DAHLSTPSQC
1110 1120 1130 1140 1150
TKRYVITNPP YEFELVPTDL IFCLMQFDHN AGQSRASLSH SSHSSQSSSK
1160 1170 1180 1190 1200
KSSSVHSIPS TANRQNRPKS RESRDKQNAT RMNRMGQAEK KWFTDEPDNA
1210 1220 1230
YPRNIQIKPM STHMANQINQ YKSTSSLIPP IREVEDEC
Length:1,238
Mass (Da):138,012
Last modified:June 7, 2017 - v1
Checksum:i1D30B46CE52377DF
GO

Computationally mapped potential isoform sequencesi

There are 69 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q12791KCMA1_HUMAN
Calcium-activated potassium channel...
KCNMA1 KCNMA, SLO
1,236Annotation score:
A0A1W2PRT6A0A1W2PRT6_HUMAN
Calcium-activated potassium channel...
KCNMA1
383Annotation score:
Q5SVJ8Q5SVJ8_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,288Annotation score:
B7ZMF5B7ZMF5_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,208Annotation score:
D5MRH1D5MRH1_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,128Annotation score:
Q5SVK0Q5SVK0_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,195Annotation score:
Q5SVK5Q5SVK5_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,232Annotation score:
H0Y379H0Y379_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,192Annotation score:
Q5SVJ9Q5SVJ9_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,235Annotation score:
H0Y5Z6H0Y5Z6_HUMAN
Calcium-activated potassium channel...
KCNMA1 hCG_25279
1,207Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011439 Genomic DNA No translation available.
AC021032 Genomic DNA No translation available.
AC067745 Genomic DNA No translation available.
AL157833 Genomic DNA No translation available.
AL607069 Genomic DNA No translation available.
AL627447 Genomic DNA No translation available.
AL731556 Genomic DNA No translation available.
AL731560 Genomic DNA No translation available.
AL731575 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000640605; ENSP00000491435; ENSG00000156113

Similar proteinsi

Entry informationi

Entry nameiA0A1W2PPZ1_HUMAN
AccessioniPrimary (citable) accession number: A0A1W2PPZ1
Entry historyiIntegrated into UniProtKB/TrEMBL: June 7, 2017
Last sequence update: June 7, 2017
Last modified: July 18, 2018
This is version 10 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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