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UniProtKB - A0A1W2PPS1 (A0A1W2PPS1_HUMAN)
Protein
Submitted name:
Heterogeneous nuclear ribonucleoprotein U
Gene
HNRNPU
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Heterogeneous nuclear ribonucleoprotein U |
Gene namesi | Name:HNRNPU |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5048, HNRNPU |
VEuPathDBi | HostDB:ENSG00000153187 |
PTM / Processingi
Keywords - PTMi
MethylationARBA annotation, PhosphoproteinARBA annotationProteomic databases
PeptideAtlasi | A0A1W2PPS1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 42 | SAPInterPro annotationAdd BLAST | 35 | |
Domaini | 249 – 445 | B30.2/SPRYInterPro annotationAdd BLAST | 197 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 41 – 237 | DisorderedSequence analysisAdd BLAST | 197 | |
Regioni | 652 – 730 | DisorderedSequence analysisAdd BLAST | 79 | |
Regioni | 750 – 780 | DisorderedSequence analysisAdd BLAST | 31 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 79 – 99 | Acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 122 – 154 | Acidic residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 161 – 178 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 216 – 237 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 652 – 668 | Basic and acidic residuesSequence analysisAdd BLAST | 17 |
Phylogenomic databases
GeneTreei | ENSGT00940000156546 |
Family and domain databases
CDDi | cd12884, SPRY_hnRNP, 1 hit |
Gene3Di | 1.10.720.30, 1 hit 2.60.120.920, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR013320, ConA-like_dom_sf IPR026745, hnRNP_U IPR027417, P-loop_NTPase IPR003034, SAP_dom IPR036361, SAP_dom_sf IPR003877, SPRY_dom IPR035778, SPRY_hnRNP_U |
PANTHERi | PTHR12381:SF11, PTHR12381:SF11, 1 hit |
Pfami | View protein in Pfam PF02037, SAP, 1 hit PF00622, SPRY, 1 hit |
SMARTi | View protein in SMART SM00513, SAP, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit SSF52540, SSF52540, 1 hit SSF68906, SSF68906, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50800, SAP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 17 potential isoforms that are computationally mapped.Show allAlign All
A0A1W2PPS1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSSPVNVKK LKVSELKEEL KKRRLSDKGL KAELMERLQA ALDDEEAGGR
60 70 80 90 100
PAMEPGNGSL DLGGDSAGRS GAGLEQEAAA GGDEEEEEEE EEEEGISALD
110 120 130 140 150
GDQMELGEEN GAAGAADSGP MEEEEAASED ENGDDQGFQE GEDELGDEEE
160 170 180 190 200
GAGDENGHGE QQPQPPATQQ QQPQQQRGAA KEAAGKSSGP TSLFAVTVAP
210 220 230 240 250
PGARQGQQQA GGDGKTEQKG GDKKRGVKRP REDHGRGYFE YIEENKYSRA
260 270 280 290 300
KSPQPPVEEE DEHFDDTVVC LDTYNCDLHF KISRDRLSAS SLTMESFAFL
310 320 330 340 350
WAGGRASYGV SKGKVCFEMK VTEKIPVRHL YTKDIDIHEV RIGWSLTTSG
360 370 380 390 400
MLLGEEEFSY GYSLKGIKTC NCETEDYGEK FDENDVITCF ANFESDEVEL
410 420 430 440 450
SYAKNGQDLG VAFKISKEVL AGRPLFPHVL CHNCAVEFNF GQKEKPYFPI
460 470 480 490 500
PEEYTFIQNV PLEDRVRGPK GPEEKKDCEV VMMIGLPGAG KTTWVTKHAA
510 520 530 540 550
ENPGKYNILG TNTIMDKMMV AGFKKQMADT GKLNTLLQRA PQCLGKFIEI
560 570 580 590 600
AARKKRNFIL DQTNVSAAAQ RRKMCLFAGF QRKAVVVCPK DEDYKQRTQK
610 620 630 640 650
KAEVEGKDLP EHAVLKMKGN FTLPEVAECF DEITYVELQK EEAQKLLEQY
660 670 680 690 700
KEESKKALPP EKKQNTGSKK SNKNKSGKNQ FNRGGGHRGR GGFNMRGGNF
710 720 730 740 750
RGGAPGNRGG YNRRGNMPQR GGGGGGSGGI GYPYPRAPVF PGRGSYSNRG
760 770 780 790 800
NYNRGGMPNR GNYNQNFRGR GNNRGYKNQS QGYNQWQQGS VHVNVLCGRV
KGPN
Computationally mapped potential isoform sequencesi
There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ00839 | HNRPU_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPU C1orf199, HNRPU, SAFA, U21.1 | 825 | Annotation score: | ||
A0A1W2PP22 | A0A1W2PP22_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPU | 181 | Annotation score: | ||
Q5RI18 | Q5RI18_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPU | 602 | Annotation score: | ||
A0A1W2PP34 | A0A1W2PP34_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPU | 546 | Annotation score: | ||
A0A1W2PP35 | A0A1W2PP35_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPU | 728 | Annotation score: | ||
A0A1W2PPH7 | A0A1W2PPH7_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPU | 549 | Annotation score: | ||
A0A1W2PPL4 | A0A1W2PPL4_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPU | 547 | Annotation score: | ||
A0A1X7SBS1 | A0A1X7SBS1_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPU | 744 | Annotation score: | ||
A0A1W2PQD4 | A0A1W2PQD4_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPU | 327 | Annotation score: | ||
A0A1W2PQ74 | A0A1W2PQ74_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPU | 372 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX323046 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000640306.1; ENSP00000491685.1; ENSG00000153187.20 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX323046 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A1W2PPS1 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A1W2PPS1 |
Genome annotation databases
Ensembli | ENST00000640306.1; ENSP00000491685.1; ENSG00000153187.20 |
Organism-specific databases
HGNCi | HGNC:5048, HNRNPU |
OpenTargetsi | ENSG00000153187 |
VEuPathDBi | HostDB:ENSG00000153187 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156546 |
Miscellaneous databases
ChiTaRSi | HNRNPU, human |
Gene expression databases
ExpressionAtlasi | A0A1W2PPS1, baseline and differential |
Family and domain databases
CDDi | cd12884, SPRY_hnRNP, 1 hit |
Gene3Di | 1.10.720.30, 1 hit 2.60.120.920, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR013320, ConA-like_dom_sf IPR026745, hnRNP_U IPR027417, P-loop_NTPase IPR003034, SAP_dom IPR036361, SAP_dom_sf IPR003877, SPRY_dom IPR035778, SPRY_hnRNP_U |
PANTHERi | PTHR12381:SF11, PTHR12381:SF11, 1 hit |
Pfami | View protein in Pfam PF02037, SAP, 1 hit PF00622, SPRY, 1 hit |
SMARTi | View protein in SMART SM00513, SAP, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit SSF52540, SSF52540, 1 hit SSF68906, SSF68906, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50800, SAP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A1W2PPS1_HUMAN | |
Accessioni | A0A1W2PPS1Primary (citable) accession number: A0A1W2PPS1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 7, 2017 |
Last sequence update: | June 7, 2017 | |
Last modified: | May 25, 2022 | |
This is version 28 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |