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UniProtKB - A0A1W2P6Y4 (A0A1W2P6Y4_MOUSE)

Entry version 20 (13 Nov 2019)
Sequence version 2 (10 Oct 2018)
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Protein
Submitted name:

Stabilin-2

Gene

Stab2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Stabilin-2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Stab2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2178743 Stab2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi545 ↔ 554PROSITE-ProRule annotation
Disulfide bondi589 ↔ 598PROSITE-ProRule annotation
Disulfide bondi608 ↔ 618PROSITE-ProRule annotation
Disulfide bondi802 ↔ 823PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A0A1W2P6Y4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A0A1W2P6Y4 baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, RepeatSAAS annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156566

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.180.10, 2 hits
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR024731 EGF_dom
IPR036378 FAS1_dom_sf
IPR000782 FAS1_domain
IPR002049 Laminin_EGF
IPR000538 Link_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12947 EGF_3, 5 hits
PF02469 Fasciclin, 2 hits
PF00193 Xlink, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01265 LINKMODULE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00181 EGF, 8 hits
SM00179 EGF_CA, 3 hits
SM00180 EGF_Lam, 2 hits
SM00554 FAS1, 2 hits
SM00445 LINK, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56436 SSF56436, 1 hit
SSF82153 SSF82153, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 9 hits
PS50213 FAS1, 2 hits
PS01241 LINK_1, 1 hit
PS50963 LINK_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A1W2P6Y4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XCLLDPDGKA SCKCAAGFQG NGTVCTAINA CEISNGGCSA KADCKRTIPG 
        60         70         80         90        100
SRVCVCKAGY TGDGIVCLEI NPCLENHGGC DRHAECTQTG PNQAVCNCLP 
       110        120        130        140        150
KYTGDGKVCT LINVCLTNNG GCSPFAFCNH TEQDQRTCTC KPDYTGDGIV 
       160        170        180        190        200
CRGSIHSELP KNPSTSQYFF QLQEHAVQEL AGPGPFTVFV PSSDSFNSES 
       210        220        230        240        250
KLKVWDKQGL MSQILRYHVV ACQQLLLENL KVITSATTLQ GEPISISVSQ 
       260        270        280        290        300
DTVLINKKAK VLSSDIISTN GVIHVIDTLL SPQNLLITPK GASGRVLLNL 
       310        320        330        340        350
TTVAANHGYT KFSKLIQDSG LLKVITDPMH TPVTLFWPTD KALQALPQEQ 
       360        370        380        390        400
QDFLFNEDNK DKLKAYLKFH VIRDTMALAS DLPRSASWKT LQGSELSVRC 
       410        420        430        440        450
GTGSDVGELF LNGQMCRIIQ RRLLFDGGVA YGIDCLLMDP TEGGRCDTFT 
       460        470        480        490        500
TFNIPGECGS CFSTPRCPLQ SKPKGVRKKC IYNPLPFRRD VEGCQNLCTL 
       510        520        530        540        550
VVHVPRCCSG YFMPDCQACP GGPDTPCNNR GMCYDQYKPT GQCQCHTGFN 
       560        570        580        590        600
GTACELCLPG RFGPDCQPCG CSEHGQCDEG ITGSGQCLCE AGWTGRFCDA 
       610        620        630        640        650
PTVVIPVCIP ACSMHATCME NNTCVCNLNY EGDGITCTAV VDFCKQNNGG 
       660        670        680        690        700
CAKVAKCSQK GTQVSCSCQK GYKGDGHSCT EIDPCANGVN GGCHEHATCR 
       710        720        730        740        750
MTGPGKQKCE CKSHYVGDGR DCEPEQLPLD RCLQDNGQCH PDANCVDLHF 
       760        770        780        790        800
QDTTVGVFHL RSPLGQYKLT FDKAKEACAK EAASIATYNQ LSYAQKAKYH 
       810        820        830        840        850
LCSAGWLESG RVAYPTIYAS KKCANIVGIV DYGTRTNKSE MWDVFCYRMK 
       860        870
GGAGFFQELS PRPGVFETPD
Length:870
Mass (Da):94,014
Last modified:October 10, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7459B9509D838DE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8R4U0STAB2_MOUSE
Stabilin-2
Stab2 Feel2, Hare
2,559Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC025501 Genomic DNA No translation available.
AC112790 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000219341; ENSMUSP00000151465; ENSMUSG00000035459

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025501 Genomic DNA No translation available.
AC112790 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

Proteomic databases

jPOSTiA0A1W2P6Y4

Genome annotation databases

EnsembliENSMUST00000219341; ENSMUSP00000151465; ENSMUSG00000035459

Organism-specific databases

MGIiMGI:2178743 Stab2

Phylogenomic databases

GeneTreeiENSGT00940000156566

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Stab2 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

ExpressionAtlasiA0A1W2P6Y4 baseline and differential

Family and domain databases

Gene3Di2.30.180.10, 2 hits
3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR024731 EGF_dom
IPR036378 FAS1_dom_sf
IPR000782 FAS1_domain
IPR002049 Laminin_EGF
IPR000538 Link_dom
PfamiView protein in Pfam
PF12947 EGF_3, 5 hits
PF02469 Fasciclin, 2 hits
PF00193 Xlink, 1 hit
PRINTSiPR01265 LINKMODULE
SMARTiView protein in SMART
SM00181 EGF, 8 hits
SM00179 EGF_CA, 3 hits
SM00180 EGF_Lam, 2 hits
SM00554 FAS1, 2 hits
SM00445 LINK, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
SSF82153 SSF82153, 2 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 9 hits
PS50213 FAS1, 2 hits
PS01241 LINK_1, 1 hit
PS50963 LINK_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1W2P6Y4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1W2P6Y4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 7, 2017
Last sequence update: October 10, 2018
Last modified: November 13, 2019
This is version 20 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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