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Entry version 17 (11 Dec 2019)
Sequence version 2 (16 Oct 2019)
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Protein
Submitted name:

Obscurin

Gene

Obscn

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ObscurinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ObscnImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2681862 Obscn

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A1W2P6H1 baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 99Ig-likeInterPro annotationAdd BLAST91
Domaini109 – 201Ig-likeInterPro annotationAdd BLAST93
Domaini234 – 320Ig-likeInterPro annotationAdd BLAST87
Domaini329 – 415Ig-likeInterPro annotationAdd BLAST87
Domaini513 – 610Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini702 – 793Ig-likeInterPro annotationAdd BLAST92
Domaini859 – 937Ig-likeInterPro annotationAdd BLAST79
Domaini951 – 1029Ig-likeInterPro annotationAdd BLAST79
Domaini1043 – 1121Ig-likeInterPro annotationAdd BLAST79
Domaini1135 – 1213Ig-likeInterPro annotationAdd BLAST79
Domaini1227 – 1315Ig-likeInterPro annotationAdd BLAST89
Domaini1319 – 1397Ig-likeInterPro annotationAdd BLAST79
Domaini1411 – 1489Ig-likeInterPro annotationAdd BLAST79
Domaini1503 – 1581Ig-likeInterPro annotationAdd BLAST79
Domaini1595 – 1683Ig-likeInterPro annotationAdd BLAST89
Domaini1692 – 1781Ig-likeInterPro annotationAdd BLAST90
Domaini1796 – 1865Ig-likeInterPro annotationAdd BLAST70
Domaini1869 – 1955Ig-likeInterPro annotationAdd BLAST87
Domaini1960 – 2044Ig-likeInterPro annotationAdd BLAST85
Domaini2138 – 2221Ig-likeInterPro annotationAdd BLAST84
Domaini2261 – 2352Ig-likeInterPro annotationAdd BLAST92
Domaini2440 – 2524Ig-likeInterPro annotationAdd BLAST85
Domaini2618 – 2702Ig-likeInterPro annotationAdd BLAST85
Domaini2798 – 2882Ig-likeInterPro annotationAdd BLAST85
Domaini2888 – 2971Ig-likeInterPro annotationAdd BLAST84
Domaini3067 – 3150Ig-likeInterPro annotationAdd BLAST84
Domaini3156 – 3240Ig-likeInterPro annotationAdd BLAST85
Domaini3325 – 3416Ig-likeInterPro annotationAdd BLAST92
Domaini3494 – 3577Ig-likeInterPro annotationAdd BLAST84
Domaini3583 – 3665Ig-likeInterPro annotationAdd BLAST83
Domaini3671 – 3753Ig-likeInterPro annotationAdd BLAST83
Domaini3759 – 3841Ig-likeInterPro annotationAdd BLAST83
Domaini3847 – 3929Ig-likeInterPro annotationAdd BLAST83
Domaini3933 – 4016Ig-likeInterPro annotationAdd BLAST84
Domaini4023 – 4107Ig-likeInterPro annotationAdd BLAST85
Domaini4113 – 4205Ig-likeInterPro annotationAdd BLAST93
Domaini4294 – 4383Ig-likeInterPro annotationAdd BLAST90
Domaini4478 – 4564Ig-likeInterPro annotationAdd BLAST87
Domaini4571 – 4665Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini4670 – 4741Ig-likeInterPro annotationAdd BLAST72
Domaini4945 – 5028Ig-likeInterPro annotationAdd BLAST84
Domaini5175 – 5264Ig-likeInterPro annotationAdd BLAST90
Domaini5307 – 5396Ig-likeInterPro annotationAdd BLAST90
Domaini5418 – 5514Ig-likeInterPro annotationAdd BLAST97
Domaini5647 – 5714SH3InterPro annotationAdd BLAST68
Domaini5740 – 5924DHInterPro annotationAdd BLAST185
Domaini5942 – 6051PHInterPro annotationAdd BLAST110
Domaini6061 – 6144Ig-likeInterPro annotationAdd BLAST84
Domaini6155 – 6233Ig-likeInterPro annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni135 – 165DisorderedSequence analysisAdd BLAST31
Regioni4798 – 4834DisorderedSequence analysisAdd BLAST37
Regioni5602 – 5644DisorderedSequence analysisAdd BLAST43
Regioni6286 – 6342DisorderedSequence analysisAdd BLAST57
Regioni6459 – 6487DisorderedSequence analysisAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili711 – 731Sequence analysisAdd BLAST21
Coiled coili2880 – 2900Sequence analysisAdd BLAST21
Coiled coili5883 – 5910Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi149 – 165PolyampholyteSequence analysisAdd BLAST17
Compositional biasi4798 – 4826PolyampholyteSequence analysisAdd BLAST29
Compositional biasi5621 – 5637PolarSequence analysisAdd BLAST17
Compositional biasi6291 – 6312PolarSequence analysisAdd BLAST22
Compositional biasi6463 – 6480PolyampholyteSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154756

Identification of Orthologs from Complete Genome Data

More...
OMAi
VGTQTWQ

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 2 hits
cd00160 RhoGEF, 1 hit
cd12025 SH3_Obscurin_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.60.40.10, 57 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR000048 IQ_motif_EF-hand-BS
IPR035526 Obscurin_SH3
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 48 hits
PF00612 IQ, 1 hit
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 52 hits
SM00408 IGc2, 46 hits
SM00406 IGv, 11 hits
SM00015 IQ, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit
SSF48726 SSF48726, 54 hits
SSF49265 SSF49265, 2 hits
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010 DH_2, 1 hit
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 44 hits
PS50096 IQ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

A0A1W2P6H1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDHSFSGAPR FLTRPKAFVV SVGKDATLSC QIVGNPTPHV SWEKDRQPVE
60 70 80 90 100
AGARFRLAQD GDVYRLTILD LALGDSGQYV CRARNAIGEA FAAVGLRVDS
110 120 130 140 150
EGTCAEQAPH FLLRPTSIRV REGADATFRC RVGGSPQPAV SWSKDGRRLG
160 170 180 190 200
PPDAPHVRVE EHGESSALRI RSARPRDGGT YEVRAENPLG SASAAAALVV
210 220 230 240 250
DSDAEVAGPP GTSTATLLAH LQQRREAMRA EGIPPSPPGA GTRTCTVTEG
260 270 280 290 300
KHARLSCFVT GEPKPETVWK KDGQLVTEGR RHVVYEDEQE NFVLKILFCK
310 320 330 340 350
QSDRGLYTCT ASNLVGQTYS SVLVVVREPT VPFKKRLQDL EVREKESATF
360 370 380 390 400
QCEVAQPATE AAWFKEETRL WASAKYDIEE EGTERRLTVR NVSADDDAVY
410 420 430 440 450
ICETTEGSRT VAELSVQGNL TRKLPRKTAV RTGDTAIFWV ELAVPEGPVR
460 470 480 490 500
WLRNQEEMVA GGRVAITAEG TCHTLTIFQC TLEDMGEVAF VSGGCRTTTQ
510 520 530 540 550
FCVSAPRRPP LYPPADPVVK AKTESSVTLS WSAPPHGDRP VTIDGYVLEK
560 570 580 590 600
RKLGAYAWSR CHEAGWLATT EFTITGVAEE GDFQFRVSAI NHFGQGPYLE
610 620 630 640 650
FPGTMHLVPM LAVKTPLKAV EAVEGGEVTF SVDLTVASSG EWFLDGEALK
660 670 680 690 700
ASSIYVIRCD RTRHMLTIRE VPARLHGAQL KFVANGIETS IQMVVRAALG
710 720 730 740 750
LPSSKLPAAA AREVLAQLHE EAQLLAELSD QAAAVTWLKD GRELSLGPKY
760 770 780 790 800
EMQVSAGRRA LLVRDVAQDD AGLYECVSRG SRTAYQLLVQ DITDGYRDWG
810 820 830 840 850
PAGPQKHMCK CAGAKIARYL GSSCYRFLQY DKGVWHWLEA ALDTRQGKGT
860 870 880 890 900
SSCSLHEKPK LVFAKGQQAH SEVKAEAGNS ATLSCEVTQA QTEVTWFKDG
910 920 930 940 950
KKLSSSSKVR MEASGCSRRL VVQQAGKADA GEYSCEAGGQ KLSFRLDVAE
960 970 980 990 1000
PKLVFAKGQQ AHSEVKAEAG ASATLSCEVA QAQTEVTWFK DGKKLSSSSK
1010 1020 1030 1040 1050
VRMEASGCSR RLVVQQAGKA DAGEYSCEAG GQKLSFRLDV AEPKMVFAKE
1060 1070 1080 1090 1100
QQARSEVKAE AGASATLSCE VAQAQTEVTW FKDGKKLSSS SKVRMEASGC
1110 1120 1130 1140 1150
SRRLVVQQAG KADAGEYSCE AGGQKLSFRL DVTEPKLVFA KEQQARSEVK
1160 1170 1180 1190 1200
AEAGNSATLS CEVAQAQTEV TWFKDGKKLS SSSKVRMEAS GCSRRLVVQQ
1210 1220 1230 1240 1250
AGKADAGEYS CEAGGQKLSF HLDVTEPKLV FAKEQQAHSE VKAEAGASAT
1260 1270 1280 1290 1300
LSCEVAQAQT EVTWFKDGKK LSSSSKVRME ASGCSRRLVV QQAGKADAGE
1310 1320 1330 1340 1350
YSCEAEGQKL SFRLDVAEPK LVFAKEQQAR SEVKAEAGAS ATLSCEVAQA
1360 1370 1380 1390 1400
QTEVTWFKDG KKLSSSSKVR VEASGCSRRL VVQQAGKADA GEYSCEAGGQ
1410 1420 1430 1440 1450
KLSFRLDVAE PKLVFAKEQQ ANSEVKAEAG ASATLSCEVA QAQTEVTWFK
1460 1470 1480 1490 1500
DGKKLSSSSK VRVEASGCSR RLVVQQAGKA DAGEYSCEAG GQKLSFRLDV
1510 1520 1530 1540 1550
AEPKLAFAKE QQAHSEVKAE AGASATLSCE VAQAQTEVTW FKDGKKLSSS
1560 1570 1580 1590 1600
SKVRVEASGC SRRLVVQQAG KADAGEYSCE AGGQKLSFRL DVAEPKLVFA
1610 1620 1630 1640 1650
KEQQAHSEVK AEAGASATLS CEVAQAQTEV TWFKDGKKLS SSSKVRVEAS
1660 1670 1680 1690 1700
GCSRRLVVQQ VGKADAGEYS CEARGQKLSF RLDVAEAESQ IPERPSRREP
1710 1720 1730 1740 1750
LVVKEHETII LTATIAAPSV AAVTWLKDGV EIRRSKRHEA TSLGDTHTLT
1760 1770 1780 1790 1800
VRGAQVLDSA IYSCRVGKEG QDFPVQVEEV AAKFSKPLEP VEGELGGTVM
1810 1820 1830 1840 1850
LVCELSPEQA EVVWRCGNTQ LRPGKRFQMT SEGPRRTLTV SGLREDDAEE
1860 1870 1880 1890 1900
YVCESRDDRT SARLTVKVPR VVKFTSGLSA MVAEEGQEAT FQCVVSPSDA
1910 1920 1930 1940 1950
GVTWYKDGMQ LQPSEKFVMV ESGASRSLTI LGLTLEDAGQ VTVEAEGASS
1960 1970 1980 1990 2000
SAALRVREAP VLFKKKLEPQ TVEERTSVTL EVELTRPWPE VKWTRNAAVL
2010 2020 2030 2040 2050
TPSENVEIRA EGARHCLVLR SVGFADRGFF GCETPDDKTQ AKLNVEMRQV
2060 2070 2080 2090 2100
RLVRGLQEVE AKEQGTASMD VELSHAEVEG SWTRDGLRLQ PGPKCHLAVQ
2110 2120 2130 2140 2150
GPVHILTLSA LQPQDSGLVA FRAEGVHTSA RLIVTELPVS FTRVLQDVVA
2160 2170 2180 2190 2200
TQKEKVTLEC ELSRPVDVRW LKDGVELRAG KAIGIVAQGT CRSLVIYRCE
2210 2220 2230 2240 2250
TGDQGVYVCD ALDAQTSASL RVQGRTYTLI FRRVLAEDAG EVKFVAENAE
2260 2270 2280 2290 2300
SRAHLRVKEL PVTLLRPLRD KIAMEKHRGV LECQVSRASA QVRWFKGGVE
2310 2320 2330 2340 2350
LQSGPKYEVV SDGLYRKLVI NDVQPEDEDT YTCDAGNVKT SAQFFVEEQS
2360 2370 2380 2390 2400
ITIVRGLKDM TVMEPAPAWF ECETSIPSVR PPKWLLGKTV LQAGGNVGLE
2410 2420 2430 2440 2450
QDGTVHRLTL HKTCSTMTGP VHFTIGKSRS SAQLVVSDIP VVLTRPLEPK
2460 2470 2480 2490 2500
AGRELQSVVL SCDFRPAPKA VQWYKDDTPL SPSEKFKMAL EGQMAELRIL
2510 2520 2530 2540 2550
RLTPADAGVY RCQAGSAQSS AEVTVEAREV TVIQPLQDAE AMEEGRVCFS
2560 2570 2580 2590 2600
CELSHKDEDI EWSLNGTPLY NDSFHEISHE GCLHTLVLKS VRQADTGTVC
2610 2620 2630 2640 2650
ATSPKVSVSA RLVVKGKPVV FLKALDDVSA EERGTLTLQC EVSDPEARVV
2660 2670 2680 2690 2700
WRKDGVELGP SDKYDFLHKA GARGLTVHDL SHEDAGLYTC QVGSKETQSK
2710 2720 2730 2740 2750
VSVHDLHVGI TKRLKTVEVL EGESCSFECV LSHESPSDPA VWTVGGKTVG
2760 2770 2780 2790 2800
GSGHFHAVRQ GRKYTLTVKD AALSDAGEVV FSVLGLTSKA SLIIRERPVD
2810 2820 2830 2840 2850
ITKPLEDQRT TLGEDVMLSC ELSRAGTSVR WLKDGKAIRK SQKYDLLSEG
2860 2870 2880 2890 2900
TRAVLVVRKA SLKDSGEYTC ETEASKSTAK LCVEEKANRF TEELADLQVE
2910 2920 2930 2940 2950
EKGRAVFTCK TEHPASVVTW RKGLLELRAS GKHVPSQEGL TLKLTINALE
2960 2970 2980 2990 3000
RTDSDTYTCD IGQARTQARL LVHGQKVRVI EDLEDTAVQE GSSAKFCCRI
3010 3020 3030 3040 3050
APADYGPVHW FLDKTPLHSN ELNEITVQPG GYHVLTLRQL ALKDSGTVYF
3060 3070 3080 3090 3100
EAGDQRTSAA LRVTEKPSIF SRPLTDVTVT EGEDLTLVCE TTTVDSSVRW
3110 3120 3130 3140 3150
TKDGKTLRPS ARCQLSHEGC QAQLLITATT PQDGGRYKCE IGGASSSSIV
3160 3170 3180 3190 3200
RVHALPVRFR ESLKDVEVPE GKAATLRCVL SSVAAPVEWR HGDDVLKSSN
3210 3220 3230 3240 3250
KYSLRQEGAV LELVIRDLQP QDSGQYSCSF GDQTTSATLT VKTSSAQFVG
3260 3270 3280 3290 3300
KLRNKEATEG TTVTLRCELT KEAPVEWKKG TETLRNGDKY SLKQDGAVCE
3310 3320 3330 3340 3350
LQICSLLVAD AGEYSCVCGQ EKTSATLTVK ALLVHFVRRL RSKEATEGDT
3360 3370 3380 3390 3400
TTLQCELSKA APVEWRKGTE TLRDGDRYSL KQDGAVCELQ IRSLTIADAG
3410 3420 3430 3440 3450
EYLCTCGQEK TSATLTVRGL PAKFIEDLRS QEATEGATAI LRCELSKAAP
3460 3470 3480 3490 3500
VEWRKGSETL KDGDRYTLRQ DGAVCELQIR GLAVVDTGTY SSLPTKFTEG
3510 3520 3530 3540 3550
LRNEEATEGT MATLRCQMSK AAPVEWRKGS ETLRDGDRYS LRQDGAMCEL
3560 3570 3580 3590 3600
QIRGLTIEDS GEYTCVCGQE KTSATLSVKA LPPRFIEDLR SQEATEGTMA
3610 3620 3630 3640 3650
TLRCQMSKAA PVEWRKGSET LGDGGRYSLR QNGAVCELQI HDLAVEDTGE
3660 3670 3680 3690 3700
YSCVCGQEKT SATLNVKALP PKFTEGLKKE EATEGTMVTL RCQMSKEATV
3710 3720 3730 3740 3750
EWRKGAKTLS DGGRYSLRQD GAMCELQICG LAVEDAGEYS CVCGQEKTSA
3760 3770 3780 3790 3800
TLSVKALPPR FIEDLRSQEA TEGTMATLRC QMSKAAPVEW RKGSETLRDG
3810 3820 3830 3840 3850
DRYSLRQDGA VCELQIRDLA VEDAGEYLCV CGQEKTSATL SVKALPPRFI
3860 3870 3880 3890 3900
EDLRSQEATE GTMATLRCQM SKAAPVEWRK GSKTLRDGDR YSLRQDGAMC
3910 3920 3930 3940 3950
ELQICDLAVE DTGDYSCVCG QEKTSATLSV KAPQVVFQQP LQNLQAEEGS
3960 3970 3980 3990 4000
MASLRCELSV PNAAMVWSKG GLELQGDTRR EARQQGCVAE LLLRDLRRED
4010 4020 4030 4040 4050
AGEYSCTCGS QTTSATLMVT AAPVRFLREL QAQDVDEGAT ARLRCELSRE
4060 4070 4080 4090 4100
AVSVEWRKGS LQLFPCAKYQ MVQEGTTAEL LVHGVEQEDA GEYTCDAGHT
4110 4120 4130 4140 4150
QSIARLSVRA PKPKFKTDLQ STEQEAGGTA RLCCQLSEAE PGTPVQWLKE
4160 4170 4180 4190 4200
GVELHVGSKY EMRRQGAVCE LLIHGLEAKD TGEYACLVGG QKTLASLRVK
4210 4220 4230 4240 4250
EPEVTIVRGL VDMEVQADED VEFTCKVSQA GATDVQWHLQ GLPLQSNEVT
4260 4270 4280 4290 4300
EVAVLADGCT HVLQLKGVTL EDAGTVSFHV GGLSSSAQLT VRVPEVTVLE
4310 4320 4330 4340 4350
PLKDVQLSEG QDAHFRCRLS RASGQEARWA LGGVPLQCNE MNDITVEQGT
4360 4370 4380 4390 4400
LYLLTLHKVT LEDAGTITLQ VGSCSSEAQL KVTAKNTVLR GLENVDALEG
4410 4420 4430 4440 4450
GEALFECQLS QPEVAAHTWL LDDEPVHTSE KVEVVYFENG LRHLLLLKNL
4460 4470 4480 4490 4500
KPQDSCRVTF LAGDVVTSAF LTVRGWRLEV LEPPHDASVK AGMQVRFTCI
4510 4520 4530 4540 4550
LSEAVPVGEA TWYINGAAIQ PDDTDWTVTT DGSHHALTLS NAQPQHAGEV
4560 4570 4580 4590 4600
TFAARDAVAS ARLSVLALPD PPEDAEVVGR SDHSVTLSWV APMSDGGGGL
4610 4620 4630 4640 4650
CGYRVEMKEA STGQWQLCHD LVPGPECVVD DLVPGKTYRF RVAAVGPAGA
4660 4670 4680 4690 4700
GEPVHLPQMV KIAPAPAPAP APAPAPETRQ AVVGEDICLE LEVAADGGEV
4710 4720 4730 4740 4750
VWHKGTERIQ PGGHFEVLSR GQRQMLVIKG FRTEDQGEYR CGPIQGLPSS
4760 4770 4780 4790 4800
GAATFNVVMT SGSGDEVPAQ PSLPPEAAQE GDLHLLWEAL ARKRRMSREP
4810 4820 4830 4840 4850
TLDSISELPE EDSRVQHLRQ EAEETAPDLS EGYSTADELA RTGEADLSHT
4860 4870 4880 4890 4900
SSDDESRAGT PSLVTYLKKA GGPGISPLAS KHEAQVTTSV KPQKQQEPVV
4910 4920 4930 4940 4950
PTCPPPGDLS AADLMDPSLD KAAVKIQAAF KGYKVRKEMK QQEGPVFSRT
4960 4970 4980 4990 5000
FGDTEAQVGD VLRLECVLAT KTDMRACWLK DGIELTDGRH YHIDQLKDGT
5010 5020 5030 5040 5050
CSLLVTGLAP TDSGRYTCQV STKSGRVSHS ACVVVSGTES EAESSSGGEL
5060 5070 5080 5090 5100
DDAFRRAARR LHRLFRTKSP AELSEEELFL SADEGPGEPE EPADWQTYRE
5110 5120 5130 5140 5150
DENFVCIRFE SLAEARQAVT CFRNMFATMG IGVEISLGEQ GPRGVEMRIG
5160 5170 5180 5190 5200
KVAPTVTPAV PLAKTPGLQT SDAAPVFLTE LQNQDVQDGY PMSFDCVVTG
5210 5220 5230 5240 5250
QPVPSVRWFK DGKLLEEDDH YMINEDQQGG HQLIITAVVP ADMGVYRCLA
5260 5270 5280 5290 5300
ENSMGVSSTK AELRVELTST DYDTAADATE TSSYFSAQGY LSSREQEGTE
5310 5320 5330 5340 5350
SDEGQLPQVL EELKDLQVAP GTRLAKFQLK VKGYPAPKLY WFKDGQPLTT
5360 5370 5380 5390 5400
SDHIRMTDKK TLHTLEIVSV TREDSGQYAA YISNAVGAAY SSARLLVRGP
5410 5420 5430 5440 5450
SEPEEKPASD VHERLVPPRI LEKFTPKKVK RGSSITFSVK VEGHPAPSVH
5460 5470 5480 5490 5500
WLKEEAEKGV LWIGPDTPGY TMASSSKQHS LVLLDVGRQH QGTYTCIATN
5510 5520 5530 5540 5550
PAGQALCSAS LHISGLAKEE EQERVKEALI SSFLQGTSQA VSAQMSESAG
5560 5570 5580 5590 5600
FADLVGQSKG ESLVAEEAHS HLSLAEVGTE EFLQKLTSQI TEMVSAKISQ
5610 5620 5630 5640 5650
AKLQVPGGDS DEETKTPSAS PRHGRSRPSS SVQESSSESE DGDSRGEIFD
5660 5670 5680 5690 5700
IYVVTADYLP LGAEQDAIIL REGQYVEVLD SAHPLRWLVR TKPTKSSPSR
5710 5720 5730 5740 5750
QGWVSPAYLD KRLKLSPEWG PTEAPEFPGE AVSEDEYRTR LSSVIQELLS
5760 5770 5780 5790 5800
SEQAFVGELQ FLESHHMKHL ERSPRVPAAV ASQKTVIFRN VQDISHFHSS
5810 5820 5830 5840 5850
FLKELQGCGT DDDVAMCFIK NQEAFEKYLE FLVGRVQAES VVVSTPVQEF
5860 5870 5880 5890 5900
YKKYAEETLS AKDPTQPPPP PLQHYLEQPV ERVQKYQALL KELIRNKARN
5910 5920 5930 5940 5950
RQNCALLEQA YAVVSALPQR AENKLHVSLM ENYPGTLEAL GEPIRQGHFI
5960 5970 5980 5990 6000
VWEGAPGARM PWKGHNRHVF LFRNYLVICK PRRDSRTDTF SYVFRNMMKL
6010 6020 6030 6040 6050
SSIDLNDQVE GDDRAFEVWH EREDSVRKYL LQARTVIIKN SWVKEICGIQ
6060 6070 6080 6090 6100
QRLAQPVWRP PEFEEELADC TAELGETVKL ACRVTGTPKP IVSWYKDGKP
6110 6120 6130 6140 6150
VEVDPHHILI EDPDGSCTLI LDNLTGIDSG QYMCFAASAA GNASTLGKIL
6160 6170 6180 6190 6200
VQVPPRFVNK VRATPFVEGE DAQITCTVEG APYPQIRWYK DGTLLAPGNR
6210 6220 6230 6240 6250
YRMLNEPRSG VLVLVIQAAS KEDLGHYECE LVNRLGSTRG GGELYMQSPA
6260 6270 6280 6290 6300
LRARDQHHRE QIVAAVEVTE QETKVPKKTV IIEETITTVV KSPRGRRQSP
6310 6320 6330 6340 6350
GKSPSRSPSR RSASPRRPGL LAPERLYPPG TSPSRRLEVE QGRKAPVPAL
6360 6370 6380 6390 6400
YVTEAEVHAP ASQSQPKWLE VEETIEVRVK KTGSRGASPV REMTSRGEGI
6410 6420 6430 6440 6450
LFTLPGGIPG RDPNANNSNN KSVYQEARTW GPAVVHVGEP FIFQVDSVGN
6460 6470 6480 6490 6500
VDWVAASPEP EQVRASQKEE NTERQEGCSD GDENTFLMEE PQDTDSLQGR
6510 6520 6530 6540 6550
DPKILTHNGR VLTLADLEDY VPQEGETFGC GDSTPSTPDE PPCEVSVLQR
6560 6570 6580 6590 6600
EISEPTVGQP VLLNVGRPPG TGATPSFFRP GSQVHSPESV SFLLREAWSG
6610 6620 6630 6640 6650
PVSAAPWTSS FHTHVQSSVD GSHGSFKTEV STQTVSFGAV GETVTLHIDP
6660
DGGEAPGPSQ G
Length:6,661
Mass (Da):725,782
Last modified:October 16, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6E68C4948031AAB3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AAJ9OBSCN_MOUSE
Obscurin
Obscn Gm878
8,886Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BX05H7BX05_MOUSE
Obscurin
Obscn
8,032Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6TJX7F6TJX7_MOUSE
Obscurin
Obscn
923Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QQ96E9QQ96_MOUSE
Obscurin
Obscn
7,496Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Z4YJE4Z4YJE4_MOUSE
Obscurin
Obscn
7,176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7DCJ0F7DCJ0_MOUSE
Obscurin
Obscn
221Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J9JIB2J9JIB2_MOUSE
Obscurin
Obscn
849Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BEB2A0A571BEB2_MOUSE
Obscurin
Obscn
296Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL645854 Genomic DNA No translation available.
AL662809 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000219084; ENSMUSP00000151217; ENSMUSG00000061462

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645854 Genomic DNA No translation available.
AL662809 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSMUST00000219084; ENSMUSP00000151217; ENSMUSG00000061462

Organism-specific databases

MGIiMGI:2681862 Obscn

Phylogenomic databases

GeneTreeiENSGT00940000154756
OMAiVGTQTWQ

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

ExpressionAtlasiA0A1W2P6H1 baseline and differential

Family and domain databases

CDDicd00063 FN3, 2 hits
cd00160 RhoGEF, 1 hit
cd12025 SH3_Obscurin_like, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.60.40.10, 57 hits
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR000048 IQ_motif_EF-hand-BS
IPR035526 Obscurin_SH3
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 48 hits
PF00612 IQ, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 52 hits
SM00408 IGc2, 46 hits
SM00406 IGv, 11 hits
SM00015 IQ, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF48726 SSF48726, 54 hits
SSF49265 SSF49265, 2 hits
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 44 hits
PS50096 IQ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1W2P6H1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1W2P6H1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 7, 2017
Last sequence update: October 16, 2019
Last modified: December 11, 2019
This is version 17 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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