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Protein

Tryptophan synthase alpha chain

Gene

trpA

Organism
Euryarchaeota archaeon ADurb.BinA087
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. no protein annotated in this organism
  5. Tryptophan synthase beta chain (trpB1_2), Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB1_1)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei47Proton acceptorUniRule annotation1
Active sitei58Proton acceptorUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00035;UER00044

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase alpha chainUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Name:trpAUniRule annotationImported
ORF Names:BWY93_00511Imported
OrganismiEuryarchaeota archaeon ADurb.BinA087Imported
Taxonomic identifieri1852879 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeota

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpA family.UniRule annotation

Family and domain databases

CDDicd04724 Tryptophan_synthase_alpha, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00131 Trp_synth_alpha, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011060 RibuloseP-bd_barrel
IPR002028 Trp_synthase_suA
PfamiView protein in Pfam
PF00290 Trp_syntA, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR00262 trpA, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1V5IJS0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSRISGAFR LRERPLIVTC VVAGDPSFAE SIQISRELVD AGADMIEIVM
60 70 80 90 100
PFSDPVADGP VIQQAGSRAR AAGMTTERLF DLVREIRRET TIPLLIMTYA
110 120 130 140 150
NIVVRRGIRK FYRDAADAGA DGVVVADVPL EEADPFCAAA RMAGIDPILF
160 170 180 190 200
ISQTTSPERM DKILAKAGGF IYLVAALGVT GTREDLAPHT IDLLKVVKER
210 220 230 240 250
TTLPVVPGFG ISTPDQVRRY AQAGADGVIV GSALIRMIGE RVSRTEGSGQ
260
GIGDLVRAMK HAACCE
Length:266
Mass (Da):28,511
Last modified:June 7, 2017 - v1
Checksum:iC3B761392C2AC274
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MVZQ01000016 Genomic DNA Translation: OPZ44435.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MVZQ01000016 Genomic DNA Translation: OPZ44435.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00035;UER00044

Family and domain databases

CDDicd04724 Tryptophan_synthase_alpha, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00131 Trp_synth_alpha, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011060 RibuloseP-bd_barrel
IPR002028 Trp_synthase_suA
PfamiView protein in Pfam
PF00290 Trp_syntA, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR00262 trpA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A1V5IJS0_9EURY
AccessioniPrimary (citable) accession number: A0A1V5IJS0
Entry historyiIntegrated into UniProtKB/TrEMBL: June 7, 2017
Last sequence update: June 7, 2017
Last modified: March 28, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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