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Entry version 14 (17 Jun 2020)
Sequence version 1 (07 Jun 2017)
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Protein
Submitted name:

Regulator of G-protein signaling 12 isoform A

Gene

RGS12

Organism
Patagioenas fasciata monilis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Regulator of G-protein signaling 12 isoform AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RGS12Imported
ORF Names:AV530_017209Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPatagioenas fasciata monilisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri372326 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeColumbiformesColumbidaePatagioenas
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000190648 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 86PDZInterPro annotationAdd BLAST78
Domaini213 – 325PIDInterPro annotationAdd BLAST113
Domaini695 – 812RGSInterPro annotationAdd BLAST118
Domaini944 – 1014RBDInterPro annotationAdd BLAST71
Domaini1016 – 1086RBDInterPro annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni593 – 631DisorderedSequence analysisAdd BLAST39
Regioni819 – 925DisorderedSequence analysisAdd BLAST107
Regioni1091 – 1142DisorderedSequence analysisAdd BLAST52
Regioni1200 – 1246DisorderedSequence analysisAdd BLAST47
Regioni1328 – 1409DisorderedSequence analysisAdd BLAST82

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi596 – 610PolyampholyteSequence analysisAdd BLAST15
Compositional biasi828 – 854PolarSequence analysisAdd BLAST27
Compositional biasi855 – 877PolyampholyteSequence analysisAdd BLAST23
Compositional biasi899 – 925PolarSequence analysisAdd BLAST27
Compositional biasi1099 – 1134PolarSequence analysisAdd BLAST36
Compositional biasi1231 – 1246PolarSequence analysisAdd BLAST16
Compositional biasi1333 – 1358Pro-richSequence analysisAdd BLAST26
Compositional biasi1376 – 1397PolarSequence analysisAdd BLAST22

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08742 RGS_RGS12, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.196.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003109 GoLoco_motif
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR003116 RBD_dom
IPR016137 RGS
IPR037880 RGS12_RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02188 GoLoco, 1 hit
PF00595 PDZ, 1 hit
PF02196 RBD, 2 hits
PF00615 RGS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01301 RGSPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00390 GoLoco, 1 hit
SM00228 PDZ, 1 hit
SM00462 PTB, 1 hit
SM00455 RBD, 2 hits
SM00315 RGS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48097 SSF48097, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50877 GOLOCO, 1 hit
PS50106 PDZ, 1 hit
PS01179 PID, 1 hit
PS50898 RBD, 2 hits
PS50132 RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A1V4JFD6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHAPPRIRSV EVARGRAGYG FTLSGQAPCV LSCVMKGSPA DYVGLKAGDQ
60 70 80 90 100
IFAVNEINVK KASHEDVVKL IGKCSGVLHM VIAEGISHID SCSSDEEVGF
110 120 130 140 150
YDGKGWLKPK PDSKALGINR AEKVVEEMQS GGIFNMIFEN PTLCAGSSDH
160 170 180 190 200
SAPKQRSFSD SAAIKFEAGH ESVSYPNLLS KEEIAKVLND DSVFRIGLEG
210 220 230 240 250
AEDFGLDASI LNVAMIVGYL GSIELPSTTS NLENESLQAI RGCMRRLRAE
260 270 280 290 300
QKIHSLVMMK IMHDCIQLCS DKSGVVAEYP AEKLAFSAVC PDDRRFFGLV
310 320 330 340 350
TMQTNDDASL AQDAEGALRT SCHVFMVDPE LFHHKIHQGI ARRFGLECTA
360 370 380 390 400
DPDTNGCLEF PTSSLPVLQF ISVLYRDMGE LIEGMRARAF LDGDADAHQN
410 420 430 440 450
NSTSSNSDSG IGNFNQEEKN NRVLVVDLGT NPSKHIPNSI WENPVGRGHN
460 470 480 490 500
QPASHWNGFC HEQEGNIPLE VIQNDKSQNV SKHLSPSARI EVPLVSSRNS
510 520 530 540 550
IPPSKKNAAG AGNQRWLPVH VLQEWQHGNV SDQESYTDST DGWSSVNCGT
560 570 580 590 600
LPPPMNKIPA DRYRVDGSFG QPQLKSHKNE WSKKMFCMQN KFGPPHSIRK
610 620 630 640 650
SKEDKKGAKF GHPMGLSQAP PPRSSVRRSF GRSKRFSITR SLDDLESATV
660 670 680 690 700
SDGELNSTDL KDCISENSLS SNASLPSVQS CRRLRERRVA SWAVSFERLL
710 720 730 740 750
QDPIGVKYFS DFLRKEFSEE NILFWQACEY FNHVPAHDKK ELSYRAREIF
760 770 780 790 800
SKFLCSKATT PVNIDSQAQL ADDILNSPHP DMFKEQQLQI FNLMKFDSYT
810 820 830 840 850
RFLKSPLYQE CILAEVEGRP LPDPQRVPSS PTSKHSISSE KSNISTPKKL
860 870 880 890 900
SGKSKSGRSL NEESGEEDTE KKKRGTFFSW SRSKSLGKSQ KRKENGDYPN
910 920 930 940 950
DSIQSNGLSY RRESQGSMSS TASLDLSETS RLPAFVPDKE KSPKYCCINL
960 970 980 990 1000
PDGSSSKMAV KSGFSIKEVL SGLCEKHGIN IAAVDLFLVG GDKPLVLHQD
1010 1020 1030 1040 1050
SSILESRDLR LEKRTLFRLD LVPINRSVGL KAKPTKPVTE VLRPVVAKYG
1060 1070 1080 1090 1100
LNLNELVARL NGEQEPLDLG VPISNLDGQR VVLDEKEPTK GRAFTDKQKG
1110 1120 1130 1140 1150
ASVKQSATVT TSRNQVSTGE GRTLGKSNSI KMKGENGKNA REVRLSKRED
1160 1170 1180 1190 1200
SIAKIGKKKC QKINLDEAEE FFELISKAQS NRADDQRGLL RKEDLILPDF
1210 1220 1230 1240 1250
LRLPPTGPEP SSSTPAGPKG LNRRVSKSEG KDGCTSPSGK QESVQNFNEN
1260 1270 1280 1290 1300
SVKKMGYSEN KHKSALTALH SQKTFSVPFN TALSPIPHAQ ENNATIWKRQ
1310 1320 1330 1340 1350
SRELQAEGIQ MVDDENVADL TLVAEGDISS PNSTLLPPPP PTPPSDTSEL
1360 1370 1380 1390 1400
PEANYPPPTP FAGANHRKKK DSQETSGNSC KQMSHKAKSS RTFNPPGVRE
1410 1420 1430 1440 1450
NPGTELPVNR IIDVDGVKLE DTSTRSCDDS EGNLSFEVYI SELSTTNLGQ
1460 1470 1480 1490 1500
EEAQNMSSLA HKCLQKMEIY ANFLSGMVEG FITRVYQIYF PERNGAQQHI
1510 1520 1530 1540 1550
TMTGTGDGDI ALPCLKTTRS AGYDQMPLDV CFPLSNEGET HFPPSPGREF
1560
SVRSLIAKLI AVYQST
Length:1,566
Mass (Da):172,542
Last modified:June 7, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF67682EC5FB1B7E8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1V4JF61A0A1V4JF61_PATFA
Regulator of G-protein signaling 12...
RGS12 AV530_017209
856Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1V4JFC2A0A1V4JFC2_PATFA
Regulator of G-protein signaling 12...
RGS12 AV530_017209
952Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1V4JFF1A0A1V4JFF1_PATFA
Regulator of G-protein signaling 12...
RGS12 AV530_017209
939Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1V4JGG4A0A1V4JGG4_PATFA
Regulator of G-protein signaling 12...
RGS12 AV530_017209
549Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LSYS01007721 Genomic DNA Translation: OPJ70856.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LSYS01007721 Genomic DNA Translation: OPJ70856.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd08742 RGS_RGS12, 1 hit
Gene3Di1.10.196.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR003109 GoLoco_motif
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR003116 RBD_dom
IPR016137 RGS
IPR037880 RGS12_RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF02188 GoLoco, 1 hit
PF00595 PDZ, 1 hit
PF02196 RBD, 2 hits
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00390 GoLoco, 1 hit
SM00228 PDZ, 1 hit
SM00462 PTB, 1 hit
SM00455 RBD, 2 hits
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS50877 GOLOCO, 1 hit
PS50106 PDZ, 1 hit
PS01179 PID, 1 hit
PS50898 RBD, 2 hits
PS50132 RGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1V4JFD6_PATFA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1V4JFD6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 7, 2017
Last sequence update: June 7, 2017
Last modified: June 17, 2020
This is version 14 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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