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Entry version 12 (12 Aug 2020)
Sequence version 1 (05 Jul 2017)
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Protein

3-hydroxy-3-methylglutaryl coenzyme A reductase

Gene

B5D07_01275

Organism
Lactobacillus reuteri
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: (R)-mevalonate degradation

This protein is involved in step 1 of the subpathway that synthesizes (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 3-hydroxy-3-methylglutaryl coenzyme A reductase (LRLP16767_LR3C6_01597), 3-hydroxy-3-methylglutaryl coenzyme A reductase (B2G46_01260), 3-hydroxy-3-methylglutaryl coenzyme A reductase (EUY87_07725), 3-hydroxy-3-methylglutaryl coenzyme A reductase (GIX74_06495), 3-hydroxy-3-methylglutaryl coenzyme A reductase (GIX51_05615), 3-hydroxy-3-methylglutaryl coenzyme A reductase (DKZ23_03665), 3-hydroxy-3-methylglutaryl coenzyme A reductase (DB324_07055), 3-hydroxy-3-methylglutaryl coenzyme A reductase (GIX80_07525), 3-hydroxy-3-methylglutaryl coenzyme A reductase (FOD75_01115), 3-hydroxy-3-methylglutaryl coenzyme A reductase (B5D07_01275), 3-hydroxy-3-methylglutaryl coenzyme A reductase (A4V07_09115), 3-hydroxy-3-methylglutaryl coenzyme A reductase (DKZ26_04505), 3-hydroxy-3-methylglutaryl coenzyme A reductase (E5337_03900), 3-hydroxy-3-methylglutaryl coenzyme A reductase (CBG24_06985), 3-hydroxy-3-methylglutaryl coenzyme A reductase (mvaA), 3-hydroxy-3-methylglutaryl coenzyme A reductase (BFD03_06730), 3-hydroxy-3-methylglutaryl coenzyme A reductase (C6H63_01775), 3-hydroxy-3-methylglutaryl coenzyme A reductase (LRLP16767_LR202_00846), 3-hydroxy-3-methylglutaryl coenzyme A reductase (DL317_05105), 3-hydroxy-3-methylglutaryl coenzyme A reductase (B1A73_02570), 3-hydroxy-3-methylglutaryl coenzyme A reductase (DKZ35_00675), 3-hydroxy-3-methylglutaryl coenzyme A reductase (CBF96_02375), 3-hydroxy-3-methylglutaryl coenzyme A reductase (mvaA), 3-hydroxy-3-methylglutaryl coenzyme A reductase (BHL83_00965), 3-hydroxy-3-methylglutaryl coenzyme A reductase (ADV92_04985), 3-hydroxy-3-methylglutaryl coenzyme A reductase (CBG21_09240), 3-hydroxy-3-methylglutaryl coenzyme A reductase (C5O77_06800), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HF82_03770), 3-hydroxy-3-methylglutaryl coenzyme A reductase (BBP13_02070)
This subpathway is part of the pathway (R)-mevalonate degradation, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate, the pathway (R)-mevalonate degradation and in Metabolic intermediate metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseUniRule annotationImportedARBA annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00257;UER00367

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
3-hydroxy-3-methylglutaryl coenzyme A reductaseUniRule annotation (EC:1.1.1.88UniRule annotation)
Short name:
HMG-CoA reductaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:B5D07_01275Imported, BHL82_02625Imported, DPH67_09735Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLactobacillus reuteriImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1598 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000315268 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000194286 Componenti: Unassembled WGS sequence
  • UP000189795 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HMG-CoA reductase family.UniRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00644, HMG-CoA_reductase_classII, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.420, 1 hit
3.90.770.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002202, HMG_CoA_Rdtase
IPR004553, HMG_CoA_Rdtase_bac-typ
IPR023074, HMG_CoA_Rdtase_cat_sf
IPR009023, HMG_CoA_Rdtase_NAD(P)-bd_sf
IPR009029, HMG_CoA_Rdtase_sub-bd_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10572, PTHR10572, 1 hit
PTHR10572:SF13, PTHR10572:SF13, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00368, HMG-CoA_red, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55035, SSF55035, 1 hit
SSF56542, SSF56542, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00532, HMG_CoA_R_NAD, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50065, HMG_COA_REDUCTASE_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1V4FN34-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDWQHGFYK LSAHDRRQQL TKARQLSPLE EQVLANTSSD LGDELVENYI
60 70 80 90 100
TDYSLPEGVA LNITVNNRQY VVPMVVEEPS VIAAASNGAH RVSRSGGFTA
110 120 130 140 150
PQQDRQLVGQ IVLDDVSDKA AVTSWLLEHQ DEILTIANQA HPSMQARGGG
160 170 180 190 200
AKSMKVRTSG DFISVDLGID VCQAMGANSV NTMAEAVGKW LTDKGFHVIT
210 220 230 240 250
AILSNLATQS LQTATCKVAF RHLATTEMDG KEVAQRIARL SDLAQVDPYR
260 270 280 290 300
AATHNKGIMN GIDAVMIASG NDWRAIESGA HAYAARDGQY RGLSTWEIQD
310 320 330 340 350
DYLVGKIVLP LPVGVIGGSI GLNKMTKINY HISQIKSAEE LAAVTASIGL
360 370 380 390 400
AQNLAALRAL TTTGIQAGHM KLQYRSLAAS VGATPAEVPL VVARLKQRSH
410 420
VDQALAKEIL STIRKVQFND
Length:420
Mass (Da):45,317
Last modified:July 5, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB356621D6078BCB9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
MWVS01000020 Genomic DNA Translation: OPG89216.1
MIMU01000150 Genomic DNA Translation: OTA81002.1
CP030089 Genomic DNA Translation: QDK49319.1

NCBI Reference Sequences

More...
RefSeqi
WP_003674568.1, NZ_RIAU01000001.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MWVS01000020 Genomic DNA Translation: OPG89216.1
MIMU01000150 Genomic DNA Translation: OTA81002.1
CP030089 Genomic DNA Translation: QDK49319.1
RefSeqiWP_003674568.1, NZ_RIAU01000001.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Enzyme and pathway databases

UniPathwayiUPA00257;UER00367

Family and domain databases

CDDicd00644, HMG-CoA_reductase_classII, 1 hit
Gene3Di3.30.70.420, 1 hit
3.90.770.10, 1 hit
InterProiView protein in InterPro
IPR002202, HMG_CoA_Rdtase
IPR004553, HMG_CoA_Rdtase_bac-typ
IPR023074, HMG_CoA_Rdtase_cat_sf
IPR009023, HMG_CoA_Rdtase_NAD(P)-bd_sf
IPR009029, HMG_CoA_Rdtase_sub-bd_dom_sf
PANTHERiPTHR10572, PTHR10572, 1 hit
PTHR10572:SF13, PTHR10572:SF13, 1 hit
PfamiView protein in Pfam
PF00368, HMG-CoA_red, 1 hit
SUPFAMiSSF55035, SSF55035, 1 hit
SSF56542, SSF56542, 1 hit
TIGRFAMsiTIGR00532, HMG_CoA_R_NAD, 1 hit
PROSITEiView protein in PROSITE
PS50065, HMG_COA_REDUCTASE_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1V4FN34_LACRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1V4FN34
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2017
Last sequence update: July 5, 2017
Last modified: August 12, 2020
This is version 12 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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