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Protein

Lipoyl-[GcvH]:protein N-lipoyltransferase

Gene

lipL

Organism
Enterococcus mundtii
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the amidotransfer (transamidation) of the lipoyl moiety from lipoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes. Takes part in a pathway for scavenging of lipoic acid.UniRule annotation

Miscellaneous

The reaction proceeds via a thioester-linked acyl-enzyme intermediate.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

[Glycine cleavage system H]-N6-lipoyl-L-lysine + a [lipoyl-carrier protein] = [glycine cleavage system H] + a [lipoyl-carrier protein]-N6-lipoyl-L-lysine.UniRule annotation

Pathwayi: protein lipoylation via exogenous pathway

This protein is involved in the pathway protein lipoylation via exogenous pathway, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway protein lipoylation via exogenous pathway and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei137Acyl-thioester intermediateUniRule annotation1
Sitei149Lowers pKa of active site CysUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, LigaseImported, Transferase

Enzyme and pathway databases

UniPathwayi
UPA00537

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoyl-[GcvH]:protein N-lipoyltransferaseUniRule annotation (EC:2.3.1.200UniRule annotation)
Alternative name(s):
Lipoyl-[GcvH]:E2 amidotransferaseUniRule annotation
Gene namesi
Name:lipLUniRule annotation
ORF Names:BTN92_00585Imported, CV769_01940Imported
OrganismiEnterococcus mundtiiImported
Taxonomic identifieri53346 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
Proteomesi
  • UP000230327 Componenti: Unassembled WGS sequence
  • UP000189299 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 217BPL/LPL catalyticInterPro annotationAdd BLAST187

Sequence similaritiesi

Belongs to the octanoyltransferase LipL family.UniRule annotation

Family and domain databases

HAMAPiMF_02119 LipL, 1 hit
InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR024897 LipL
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1V2UMC4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSIILDQEV YQTNDFSPFA LTDILTEYAK KNQQTFLHFW QYEQTIILGM
60 70 80 90 100
KDTRTPFLSE GIKVIQDAGF TPVIRNAGGL GIVSDQGILN ISLIFPQEDE
110 120 130 140 150
NKISIDEGYE QMLALTRQAF PVYADKIEAY EIKDSYCPGT YDLSINGKKF
160 170 180 190 200
AGIAQRRIKN GISVMMYLSV NGDQEKRGEL MRQFYQQALK EQFGTNGYPA
210 220 230 240 250
VAPTSMATLE KLFDTPLTVA QVKDSFIQAF TTSYPTSISM GSDIWQEANV
260 270
SPDEWHGQIE RMTQRNALKE LAYDNTL
Length:277
Mass (Da):31,345
Last modified:June 7, 2017 - v1
Checksum:iECFBCE80DD4D7FED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MSTR01000001 Genomic DNA Translation: ONN44664.1
PHIL01000005 Genomic DNA Translation: PJK26823.1
RefSeqiWP_023520051.1, NZ_PHIL01000005.1

Genome annotation databases

GeneIDi31548089

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MSTR01000001 Genomic DNA Translation: ONN44664.1
PHIL01000005 Genomic DNA Translation: PJK26823.1
RefSeqiWP_023520051.1, NZ_PHIL01000005.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi31548089

Enzyme and pathway databases

UniPathwayi
UPA00537

Family and domain databases

HAMAPiMF_02119 LipL, 1 hit
InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR024897 LipL
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A1V2UMC4_ENTMU
AccessioniPrimary (citable) accession number: A0A1V2UMC4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 7, 2017
Last sequence update: June 7, 2017
Last modified: April 25, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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