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Protein

Regulatory protein E2

Gene

E2

Organism
Human papillomavirus type 23
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.UniRule annotationSAAS annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotationSAAS annotation, DNA-bindingUniRule annotationSAAS annotation, RepressorUniRule annotationSAAS annotation
Biological processDNA replicationUniRule annotationSAAS annotation, Transcription, Transcription regulationUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein E2UniRule annotationSAAS annotation
Gene namesi
Name:E2UniRule annotationImported
OrganismiHuman papillomavirus type 23Imported
Taxonomic identifieri37955 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeFirstpapillomavirinaeBetapapillomavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Host nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleusUniRule annotationSAAS annotation

PTM / Processingi

Post-translational modificationi

Phosphorylated.UniRule annotation

Keywords - PTMi

PhosphoproteinUniRule annotation

Expressioni

Keywords - Developmental stagei

Early proteinUniRule annotation

Interactioni

Subunit structurei

Binds DNA as homodimer. Interacts with protein E1; this interaction greatly increases E1 DNA-binding activity. Interacts with protein L1; this interaction enhances E2-dependent replication and transcription activation. Interacts with protein L2; this interaction inhibits E2 transcriptional activity but not DNA replication function E2. Interacts with protein E7; this interaction inhibits E7 oncogenic activity. Interacts with host TAF1; this interaction modulates E2-dependent transcriptional regulation. Interacts with host BRD4; this interaction mediates E2 transcriptional activation function. Additionally, the interaction with host BRD4 on mitotic chromosomes mediates tethering of the viral genome. Interacts with host TOPBP1; this interaction is required for optimal viral DNA replication.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 198PPV_E2_NInterPro annotationAdd BLAST198
Domaini349 – 427PPV_E2_CInterPro annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni347 – 431DNA-binding domainUniRule annotationAdd BLAST85

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 21Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the papillomaviridae E2 protein family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3Di3.30.70.330, 1 hit
HAMAPiMF_04001 PPV_E2, 1 hit
InterProiView protein in InterPro
IPR035975 E2/EBNA1_C_sf
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR000427 Papillomavirus_E2_C
IPR001866 Papillomavirus_E2_N
IPR033668 Reg_prot_E2
IPR036050 Regulatory_protein_E2_N
PfamiView protein in Pfam
PF00511 PPV_E2_C, 1 hit
PF00508 PPV_E2_N, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000672 E2_early_recog_prot_C, 1 hit
SUPFAMiSSF51332 SSF51332, 1 hit
SSF54957 SSF54957, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1V0CLX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEALSERFSA LQDKLMDLYE SGLEDLETQI QHWKLLRQEQ ILLYYARKRG
60 70 80 90 100
IMRLGYQPVP PLATSEIKAK DAIAIGILLE SLQRSKYADE PWTLVETSLE
110 120 130 140 150
TIRSPPIDCF KKGPKTVEVY FDGDPENIMP YTVWSYIYYQ TDEDTWEKVE
160 170 180 190 200
GHVDYTGAYF YEGQLKNYYI KFEADAKRFG TTGMWEVHVN KDTVFTPVTS
210 220 230 240 250
STPPVGDASN NAVPEESTTS LSSPQRSPSS NRRYGRKASS PTATTRRQKR
260 270 280 290 300
QRKETLSRRR KTRSRSRSRE QRGGRETRRS SSRGASKSPR RGGRSGGGPL
310 320 330 340 350
TRSRSRSRSP ESFTGGGVAP SEVGATLRSV SRHNSGRLAQ LLESAKDPPV
360 370 380 390 400
ILLRGGANTL KCYRYRFRKK HAGKFHYVST TWSWIGEHSN DRIGRARMLI
410 420 430
AFHSNHEREK CIQEMKLPLG VDWSYGQFDD L
Length:431
Mass (Da):49,186
Last modified:June 7, 2017 - v1
Checksum:i0E7B4AA1AB462B81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KY652675 Genomic DNA Translation: ARA71352.1

Similar proteinsi

Entry informationi

Entry nameiA0A1V0CLX3_HPV23
AccessioniPrimary (citable) accession number: A0A1V0CLX3
Entry historyiIntegrated into UniProtKB/TrEMBL: June 7, 2017
Last sequence update: June 7, 2017
Last modified: July 18, 2018
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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