UniProtKB - A0A1U9X830 (A0A1U9X830_HUMAN)
Protein
Negative elongation factor E
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: UniProtKB-UniRule
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | RNA-bindingPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Negative elongation factor EARBA annotation |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- NELF complex Source: InterPro
- nuclear body Source: HPA
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Keywords - Cellular componenti
NucleusARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 262 – 332 | RRMInterPro annotationAdd BLAST | 71 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 30 – 67 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 79 – 258 | DisorderedSequence analysisAdd BLAST | 180 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 32 – 67 | PolarSequence analysisAdd BLAST | 36 | |
Compositional biasi | 83 – 100 | PolyampholyteSequence analysisAdd BLAST | 18 | |
Compositional biasi | 183 – 257 | PolyampholyteSequence analysisAdd BLAST | 75 |
Sequence similaritiesi
Belongs to the RRM NELF-E family.ARBA annotation
Phylogenomic databases
OrthoDBi | 1377312at2759 |
Family and domain databases
CDDi | cd12305, RRM_NELFE, 1 hit |
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR033102, NELFE IPR034637, NELFE_RRM IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
PANTHERi | PTHR17250, PTHR17250, 2 hits |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A1U9X830-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLVIPPGLSE EEEALQKKFN KLKKKKKALL ALKKQSSSST TSQGGVKRSL
60 70 80 90 100
SEQPVMDTAT ATEQAKQLVK SGAISAIKAE TKNSGFKRSR TLEGKLKDPE
110 120 130 140 150
KGPVPTFQPF QRSISADDDL QESSRRPQRK SLYESFVSSS DRLRELGPDG
160 170 180 190 200
EEAEGPGAGD GPPRSFDWGY EERSGAHSSA SPPRSRSRDR SHERNRDRDR
210 220 230 240 250
DRERDRDRDR DRDRERDRDR DRDRDRDRER DRDRERDRDR DREGPFRRSD
260 270 280 290 300
SFPERRAPRK GNTLYVYGED MTPTLLRGAF SPFGNIIDLS MDPPRNCAFV
310 320 330 340 350
TYEKMESADQ AVAELNGTQV ESVQLKVNIA RKQPMLDAAT GKSVWGSLAV
360 370 380
QNSPKGCHRD KRTQIVYSDD VYKENLVDGF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KY500479 Genomic DNA Translation: AQY76952.1 |
RefSeqi | NP_002895.3, NM_002904.5 |
Genome annotation databases
GeneIDi | 7936 |
KEGGi | hsa:7936 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KY500479 Genomic DNA Translation: AQY76952.1 |
RefSeqi | NP_002895.3, NM_002904.5 |
3D structure databases
SMRi | A0A1U9X830 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 1924, 146 antibodies |
Genome annotation databases
GeneIDi | 7936 |
KEGGi | hsa:7936 |
Organism-specific databases
CTDi | 7936 |
Phylogenomic databases
OrthoDBi | 1377312at2759 |
Miscellaneous databases
GenomeRNAii | 7936 |
Gene expression databases
ExpressionAtlasi | A0A1U9X830, baseline and differential |
Family and domain databases
CDDi | cd12305, RRM_NELFE, 1 hit |
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR033102, NELFE IPR034637, NELFE_RRM IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
PANTHERi | PTHR17250, PTHR17250, 2 hits |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A1U9X830_HUMAN | |
Accessioni | A0A1U9X830Primary (citable) accession number: A0A1U9X830 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 7, 2017 |
Last sequence update: | June 7, 2017 | |
Last modified: | February 10, 2021 | |
This is version 24 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |