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Entry version 17 (12 Aug 2020)
Sequence version 1 (10 May 2017)
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Protein

ABC multidrug transporter atrA

Gene

atrA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pleiotropic ABC efflux transporter involved in the basal level of drugs susceptivbility, including antibiotics, azole fungicides and plant defense toxins.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi865 – 872ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ABC multidrug transporter atrA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:AN8928
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri227321 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillusAspergillus subgen. Nidulantes
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000560 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VII
  • UP000005890 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei499 – 519HelicalSequence analysisAdd BLAST21
Transmembranei533 – 553HelicalSequence analysisAdd BLAST21
Transmembranei583 – 603HelicalSequence analysisAdd BLAST21
Transmembranei608 – 628HelicalSequence analysisAdd BLAST21
Transmembranei642 – 662HelicalSequence analysisAdd BLAST21
Transmembranei747 – 767HelicalSequence analysisAdd BLAST21
Transmembranei1168 – 1188HelicalSequence analysisAdd BLAST21
Transmembranei1195 – 1215HelicalSequence analysisAdd BLAST21
Transmembranei1244 – 1264HelicalSequence analysisAdd BLAST21
Transmembranei1283 – 1303HelicalSequence analysisAdd BLAST21
Transmembranei1312 – 1332HelicalSequence analysisAdd BLAST21
Transmembranei1434 – 1454HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004494631 – 1466ABC multidrug transporter atrAAdd BLAST1466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi46N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi111N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi249N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi310N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi523N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi735N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi768N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1381N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is strongly increased by imazalil (PubMed:9180695). Expression is also strongly increased in the presence of hygromycin and 4-nitroquinoline oxide (4-NQO) (PubMed:11872487). Curiously, expression is repressed in the presence of camptothecin, imazalil and itraconazole (PubMed:11872487).2 Publications

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini135 – 386ABC transporter 1PROSITE-ProRule annotationAdd BLAST252
Domaini829 – 1071ABC transporter 2PROSITE-ProRule annotationAdd BLAST243

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0065, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000604_35_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
LPRPAMK

Database of Orthologous Groups

More...
OrthoDBi
56980at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03233, ABCG_PDR_domain1, 1 hit
cd03232, ABCG_PDR_domain2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR013525, ABC_2_trans
IPR029481, ABC_trans_N
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR034001, ABCG_PDR_1
IPR034003, ABCG_PDR_2
IPR027417, P-loop_NTPase
IPR010929, PDR_CDR_ABC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01061, ABC2_membrane, 2 hits
PF00005, ABC_tran, 2 hits
PF14510, ABC_trans_N, 1 hit
PF06422, PDR_CDR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1U8QT10-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVPDELPPG SSETDTIVSS SQPTNRSPMD LISEAESLNL RRIATNQSKA
60 70 80 90 100
QCRPGSAAVP SHDNPPNDDL EDATLDPNSA SFSLEKWLRA AVSDASQHGL
110 120 130 140 150
STPSGGILFR NLTVSGSGSA LQLQPTVGSV LTAPLRFASL LRHRRIEPRR
160 170 180 190 200
ILHGFDGVMK TGELLLVLGR PGAGCSTFLK TVCGETNGLH IDADSVLHYN
210 220 230 240 250
GVSQQRMMKE FKGEVVYNQE VDKHFPHLTV RQTLEFAAAA RTPAHRFQNM
260 270 280 290 300
SRDEFASYAA SVVMAIFGLS HTHNTKVGND FVRGVSGGER KRVSIAEMAL
310 320 330 340 350
AMTPFAAWDN SSRGLDSATA LKFVQALRLS ADLAGAAHAV AIYQASQSIY
360 370 380 390 400
EVFDKVTVLY EGRMIFFGPT GTAKEYFERM GWVCPARQTT GDFLTSITNP
410 420 430 440 450
LERKARAGME DVVPKTPKDF EIYWRQSPEY KTLLGEMTEF ETQHPTGNDE
460 470 480 490 500
QASAELRARK ENSQSRNSRA ASPYILSIPM QIKLNTKRAY QRIWNDMSST
510 520 530 540 550
MSTVVGQIVI ALITGSVFYD SPNTTAGFQS KGGTLFYAVL LNALTAMSEI
560 570 580 590 600
TSLYSQRPIV EKQASYAFYH PATEAIAGVV SDVPVKFLLA VAFNVIMYFL
610 620 630 640 650
ANLRREPAQF FIYFLMSFTV MFVMSAVFRT MAAVTKNAAQ AMGLAGVLML
660 670 680 690 700
ALVVYTGYVL PVPSMHPWFE WIHYLNPIYY AFEAMIANEF HGRDFDCIAF
710 720 730 740 750
VPSYADLDGD SFSCSSLGSV AGERMVSGDS YINFNYTYTY SHVWRNFGVL
760 770 780 790 800
LAFLIGFMAI YFLASELNSS TTSTAEALVF RRGHVPEYMR PGYTRPTDEE
810 820 830 840 850
KAVTQSDIKP SSPSPTNTDL PLPPQRDIFT WKDISYDIEI KGEPRRLLDD
860 870 880 890 900
VSGWVKPGTL TALMGVSGAG KTTLLDVLAH RTTMGVITGD MFVNGKGLDA
910 920 930 940 950
SFQRKTGYVQ QQDLHLETAT VRESLRFSAL LRQPASVSIR EKHDYVESVI
960 970 980 990 1000
EMLGMGDFAE AVVGTPGEGL NVEQRKLLTI GVELAAKPKL LLFLDEPTSG
1010 1020 1030 1040 1050
LDSQSSWAIC TFLRKLADSG QAVLCTIHQP SAILFQEFDQ LLFLAKGGKT
1060 1070 1080 1090 1100
VYFGPIGPNS RTLLDYFESN GARKCDEAEN PAEYMIEVVN AEVNDRGTDW
1110 1120 1130 1140 1150
FDVWKGSKEC QAVKEEIERI HEKKRGTAGA IEETDDGSTK SEFAMPFWFQ
1160 1170 1180 1190 1200
LYVVTVRVFQ QYWRMPEYII SKGALAIVAG LFIGFSFYDA KTSLAGLQTL
1210 1220 1230 1240 1250
VFSLFMVCAL FAPLVNQIMP LFITQRSLYE VRERPSKAYS WKAFLIANIL
1260 1270 1280 1290 1300
VEIPYQVLMG ILTFVCYYYP VVGSSQGPDR EGLVLLFCIQ FYVYASTFAH
1310 1320 1330 1340 1350
MCIAAMPNAE TASPIVILLF SMCLTFCGVM QPPDALPGFW IFMYRVSPFT
1360 1370 1380 1390 1400
YWVAGMATTQ VHGREVVCGE NELSIFDPPT NQTCGQYMER YISVAGGQVL
1410 1420 1430 1440 1450
NPSATAGCEY CSLTVADEYL AASQIYWSDR WRNFGLIWVY IGFNIFVATA
1460
VYYLFRVKKW NGRRKK
Length:1,466
Mass (Da):162,817
Last modified:May 10, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A11334F185D1FA3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BN001307 Genomic DNA Translation: CBF84638.1
AACD01000165 Genomic DNA Translation: EAA64062.1

NCBI Reference Sequences

More...
RefSeqi
XP_682197.1, XM_677105.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CBF84638; CBF84638; ANIA_08928
EAA64062; EAA64062; AN8928.2

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2868201

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ani:AN8928.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BN001307 Genomic DNA Translation: CBF84638.1
AACD01000165 Genomic DNA Translation: EAA64062.1
RefSeqiXP_682197.1, XM_677105.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblFungiiCBF84638; CBF84638; ANIA_08928
EAA64062; EAA64062; AN8928.2
GeneIDi2868201
KEGGiani:AN8928.2

Phylogenomic databases

eggNOGiKOG0065, Eukaryota
HOGENOMiCLU_000604_35_0_1
OMAiLPRPAMK
OrthoDBi56980at2759

Family and domain databases

CDDicd03233, ABCG_PDR_domain1, 1 hit
cd03232, ABCG_PDR_domain2, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR013525, ABC_2_trans
IPR029481, ABC_trans_N
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR034001, ABCG_PDR_1
IPR034003, ABCG_PDR_2
IPR027417, P-loop_NTPase
IPR010929, PDR_CDR_ABC
PfamiView protein in Pfam
PF01061, ABC2_membrane, 2 hits
PF00005, ABC_tran, 2 hits
PF14510, ABC_trans_N, 1 hit
PF06422, PDR_CDR, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATRA_EMENI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1U8QT10
Secondary accession number(s): C8VLI2, Q5AS02
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 22, 2020
Last sequence update: May 10, 2017
Last modified: August 12, 2020
This is version 17 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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