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Entry version 14 (03 Jul 2019)
Sequence version 1 (10 May 2017)
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Protein
Submitted name:

Envelope protein UL78

Gene

UL78

Organism
Human cytomegalovirus (HHV-5) (Human herpesvirus 5)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Envelope protein UL78Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UL78Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman cytomegalovirus (HHV-5) (Human herpesvirus 5)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10359 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei42 – 65HelicalSequence analysisAdd BLAST24
Transmembranei72 – 91HelicalSequence analysisAdd BLAST20
Transmembranei111 – 132HelicalSequence analysisAdd BLAST22
Transmembranei153 – 176HelicalSequence analysisAdd BLAST24
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei229 – 251HelicalSequence analysisAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Viral envelope proteinImported, Virion

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini53 – 295G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST243

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
14482at10239

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017452 GPCR_Rhodpsn_7TM

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1U8QMU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPSVEETTS VTESIMFAIV SFKHMGPFEG YSMSADRAAS DLLIGMFGSV
60 70 80 90 100
SLVNLLTIIG CLWVLRVTRP PVSVMIFTWN LVLSQFFSIL ATMLSKGIML
110 120 130 140 150
RGALNLSLCR LVLFVDDVGL YSTALFFLFL ILDRLSAISY GRDLWHHETR
160 170 180 190 200
ENAGVALYAV AFAWVLSIVA AVPTAATGSL DYRWLGCQIP IQYAAVDLTI
210 220 230 240 250
KMWFLLGAPM IAVLANVVEL AYSDRRDHVW SYVGRVCTFY VTCLMLFVPY
260 270 280 290 300
YCFRVLRGVL QPASAAGTGF GIMDYVELAT RTLLTMRLGI LPLFIIAFFS
310 320 330 340 350
REPTKDLDDS FDYLVERCQQ SCHGHFVRRL VQALKRAMYS VELAVCYFST
360 370 380 390 400
SVRDVAEAVK KSSSRCYADA TSAAVVVTTT TSEKATLVEH AEGMASEMCP
410 420 430
GTTIDVSAES SSVLCTDGEN TVASDATVTA L
Length:431
Mass (Da):47,357
Last modified:May 10, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i34668FE7F908C657
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GU179001 Genomic DNA Translation: ACZ72821.1
JX512200 Genomic DNA Translation: AFR55060.1
JX512203 Genomic DNA Translation: AFR55562.1
KC519323 Genomic DNA Translation: AHB20046.1
KJ361946 Genomic DNA Translation: AHJ81957.1
KJ361953 Genomic DNA Translation: AHJ83135.1
KJ361958 Genomic DNA Translation: AHJ83977.1
KJ361959 Genomic DNA Translation: AHJ84145.1
KJ361970 Genomic DNA Translation: AHJ85997.1
KJ872542 Genomic DNA Translation: AIC80664.1
KM192298 Genomic DNA Translation: AII79512.1
KM192299 Genomic DNA Translation: AII79680.1
KM192300 Genomic DNA Translation: AII79845.1
KM192301 Genomic DNA Translation: AII80004.1
KM192302 Genomic DNA Translation: AII80171.1
KP973623 Genomic DNA Translation: AJY54739.1
KP973624 Genomic DNA Translation: AJY54906.1
KP973625 Genomic DNA Translation: AJY55073.1
KP973626 Genomic DNA Translation: AJY55240.1
KP973627 Genomic DNA Translation: AJY55407.1
KP973628 Genomic DNA Translation: AJY55574.1
KP973629 Genomic DNA Translation: AJY55741.1
KP973630 Genomic DNA Translation: AJY55908.1
KP973631 Genomic DNA Translation: AJY56075.1
KP973632 Genomic DNA Translation: AJY56242.1
KP973633 Genomic DNA Translation: AJY56409.1
KP973634 Genomic DNA Translation: AJY56576.1
KP973635 Genomic DNA Translation: AJY56743.1
KP973636 Genomic DNA Translation: AJY56910.1
KP973637 Genomic DNA Translation: AJY57077.1
KP973638 Genomic DNA Translation: AJY57244.1
KP973639 Genomic DNA Translation: AJY57411.1
KP973640 Genomic DNA Translation: AJY57578.1
KP973641 Genomic DNA Translation: AJY57745.1
KP973642 Genomic DNA Translation: AJY57911.1
KP745642 Genomic DNA Translation: AKI09132.1
KP745644 Genomic DNA Translation: AKI09468.1
KP745646 Genomic DNA Translation: AKI09804.1
KP745647 Genomic DNA Translation: AKI09973.1
KP745653 Genomic DNA Translation: AKI10978.1
KP745657 Genomic DNA Translation: AKI11643.1
KP745669 Genomic DNA Translation: AKI13644.1
KP745673 Genomic DNA Translation: AKI14312.1
KP745676 Genomic DNA Translation: AKI14816.1
KP745678 Genomic DNA Translation: AKI15152.1
KP745686 Genomic DNA Translation: AKI16488.1
KP745687 Genomic DNA Translation: AKI16651.1
KP745701 Genomic DNA Translation: AKI18992.1
KP745705 Genomic DNA Translation: AKI19661.1
KP745716 Genomic DNA Translation: AKI21502.1
KP745717 Genomic DNA Translation: AKI21668.1
KR534197 Genomic DNA Translation: AKI23872.1
KR534198 Genomic DNA Translation: AKI24040.1
KR534203 Genomic DNA Translation: AKI24885.1
KR534206 Genomic DNA Translation: AKI25394.1
KR534210 Genomic DNA Translation: AKI26067.1
KU221090 Genomic DNA Translation: ALT14659.1
KU221091 Genomic DNA Translation: ALT14824.1
KU221092 Genomic DNA Translation: ALT14989.1
KU221093 Genomic DNA Translation: ALT15154.1
KU221094 Genomic DNA Translation: ALT15319.1
KU221095 Genomic DNA Translation: ALT15484.1
KU221096 Genomic DNA Translation: ALT15649.1
KU221097 Genomic DNA Translation: ALT15814.1
KU221098 Genomic DNA Translation: ALT15979.1
KU221099 Genomic DNA Translation: ALT16135.1
KU221100 Genomic DNA Translation: ALT16300.1
KT726952 Genomic DNA Translation: AMJ54607.1
KU550090 Genomic DNA Translation: AMO64921.1
KX544832 Genomic DNA Translation: APA45209.1
KX544834 Genomic DNA Translation: APA45463.1
KX544835 Genomic DNA Translation: APA45582.1
KX544838 Genomic DNA Translation: APA45950.1
KY123651 Genomic DNA Translation: APG57607.1
KY490061 Genomic DNA Translation: AQN69352.1
KY490063 Genomic DNA Translation: AQN69689.1
KY490078 Genomic DNA Translation: AQN72215.1
KY490080 Genomic DNA Translation: AQN72552.1
KY490081 Genomic DNA Translation: AQN72720.1
KY490087 Genomic DNA Translation: AQN73732.1
MF084223 Genomic DNA Translation: ARX80290.1

NCBI Reference Sequences

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RefSeqi
YP_081526.1, NC_006273.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
3077549

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:3077549

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU179001 Genomic DNA Translation: ACZ72821.1
JX512200 Genomic DNA Translation: AFR55060.1
JX512203 Genomic DNA Translation: AFR55562.1
KC519323 Genomic DNA Translation: AHB20046.1
KJ361946 Genomic DNA Translation: AHJ81957.1
KJ361953 Genomic DNA Translation: AHJ83135.1
KJ361958 Genomic DNA Translation: AHJ83977.1
KJ361959 Genomic DNA Translation: AHJ84145.1
KJ361970 Genomic DNA Translation: AHJ85997.1
KJ872542 Genomic DNA Translation: AIC80664.1
KM192298 Genomic DNA Translation: AII79512.1
KM192299 Genomic DNA Translation: AII79680.1
KM192300 Genomic DNA Translation: AII79845.1
KM192301 Genomic DNA Translation: AII80004.1
KM192302 Genomic DNA Translation: AII80171.1
KP973623 Genomic DNA Translation: AJY54739.1
KP973624 Genomic DNA Translation: AJY54906.1
KP973625 Genomic DNA Translation: AJY55073.1
KP973626 Genomic DNA Translation: AJY55240.1
KP973627 Genomic DNA Translation: AJY55407.1
KP973628 Genomic DNA Translation: AJY55574.1
KP973629 Genomic DNA Translation: AJY55741.1
KP973630 Genomic DNA Translation: AJY55908.1
KP973631 Genomic DNA Translation: AJY56075.1
KP973632 Genomic DNA Translation: AJY56242.1
KP973633 Genomic DNA Translation: AJY56409.1
KP973634 Genomic DNA Translation: AJY56576.1
KP973635 Genomic DNA Translation: AJY56743.1
KP973636 Genomic DNA Translation: AJY56910.1
KP973637 Genomic DNA Translation: AJY57077.1
KP973638 Genomic DNA Translation: AJY57244.1
KP973639 Genomic DNA Translation: AJY57411.1
KP973640 Genomic DNA Translation: AJY57578.1
KP973641 Genomic DNA Translation: AJY57745.1
KP973642 Genomic DNA Translation: AJY57911.1
KP745642 Genomic DNA Translation: AKI09132.1
KP745644 Genomic DNA Translation: AKI09468.1
KP745646 Genomic DNA Translation: AKI09804.1
KP745647 Genomic DNA Translation: AKI09973.1
KP745653 Genomic DNA Translation: AKI10978.1
KP745657 Genomic DNA Translation: AKI11643.1
KP745669 Genomic DNA Translation: AKI13644.1
KP745673 Genomic DNA Translation: AKI14312.1
KP745676 Genomic DNA Translation: AKI14816.1
KP745678 Genomic DNA Translation: AKI15152.1
KP745686 Genomic DNA Translation: AKI16488.1
KP745687 Genomic DNA Translation: AKI16651.1
KP745701 Genomic DNA Translation: AKI18992.1
KP745705 Genomic DNA Translation: AKI19661.1
KP745716 Genomic DNA Translation: AKI21502.1
KP745717 Genomic DNA Translation: AKI21668.1
KR534197 Genomic DNA Translation: AKI23872.1
KR534198 Genomic DNA Translation: AKI24040.1
KR534203 Genomic DNA Translation: AKI24885.1
KR534206 Genomic DNA Translation: AKI25394.1
KR534210 Genomic DNA Translation: AKI26067.1
KU221090 Genomic DNA Translation: ALT14659.1
KU221091 Genomic DNA Translation: ALT14824.1
KU221092 Genomic DNA Translation: ALT14989.1
KU221093 Genomic DNA Translation: ALT15154.1
KU221094 Genomic DNA Translation: ALT15319.1
KU221095 Genomic DNA Translation: ALT15484.1
KU221096 Genomic DNA Translation: ALT15649.1
KU221097 Genomic DNA Translation: ALT15814.1
KU221098 Genomic DNA Translation: ALT15979.1
KU221099 Genomic DNA Translation: ALT16135.1
KU221100 Genomic DNA Translation: ALT16300.1
KT726952 Genomic DNA Translation: AMJ54607.1
KU550090 Genomic DNA Translation: AMO64921.1
KX544832 Genomic DNA Translation: APA45209.1
KX544834 Genomic DNA Translation: APA45463.1
KX544835 Genomic DNA Translation: APA45582.1
KX544838 Genomic DNA Translation: APA45950.1
KY123651 Genomic DNA Translation: APG57607.1
KY490061 Genomic DNA Translation: AQN69352.1
KY490063 Genomic DNA Translation: AQN69689.1
KY490078 Genomic DNA Translation: AQN72215.1
KY490080 Genomic DNA Translation: AQN72552.1
KY490081 Genomic DNA Translation: AQN72720.1
KY490087 Genomic DNA Translation: AQN73732.1
MF084223 Genomic DNA Translation: ARX80290.1
RefSeqiYP_081526.1, NC_006273.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3077549
KEGGivg:3077549

Phylogenomic databases

OrthoDBi14482at10239

Family and domain databases

InterProiView protein in InterPro
IPR017452 GPCR_Rhodpsn_7TM
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1U8QMU6_HCMV
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1U8QMU6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: July 3, 2019
This is version 14 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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