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Protein

RNA polymerase II transcription factor B subunit 2

Gene

LOC107925028

Organism
Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
Name:LOC107925028Imported
OrganismiGossypium hirsutum (Upland cotton) (Gossypium mexicanum)Imported
Taxonomic identifieri3635 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsMalvalesMalvaceaeMalvoideaeGossypium
Proteomesi
  • UP000189702 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

KOiK03144

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 2 hits
PfamiView protein in Pfam
PF03849 Tfb2, 2 hits

Sequencei

Sequence statusi: Complete.

A0A1U8L907-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQVKIIAKN FMDMVASLPA IKLDLLYRNQ FICEAILRSL PPLAKKYVLQ
60 70 80 90 100
MLYIDIPITS KSLQEWLLAD GSSKHKVAID RLIQLRVFEV IDRKKETTYK
110 120 130 140 150
LNSTFQTNLR KHMISGGILP REPMPQSVTA RLPTSEELDA YAHEQWECFL
160 170 180 190 200
LQLISSGQAE KSTSFSSSMM RIFQRGLLRQ RDKEAPRLTE SGFQFLLMDT
210 220 230 240 250
NAQLWYIIRE YISNSEEQGV DQADLIAFLL ELSFHTPGEV FKLATNLSVS
260 270 280 290 300
LTDSSSRKQG FVVVETNFRM YAYSSSKLHC EILRLFARVE YQLPNLIVGA
310 320 330 340 350
ITKESLYNAF ENGITAEQIV TFLQQNAHPR VAAKIPSVPE NVTDQIRLWE
360 370 380 390 400
TDLNRVEMTP AHFYDEFPSR DVFEAASDFA RMHNGLLWED AKKMRMVVKA
410
EIHMLMREHL RGQNK
Length:415
Mass (Da):47,821
Last modified:May 10, 2017 - v1
Checksum:iDCB428C35A64F2C7
GO

Sequence databases

RefSeqiXP_016711087.1, XM_016855598.1

Genome annotation databases

GeneIDi107925028
KEGGighi:107925028

Similar proteinsi

Entry informationi

Entry nameiA0A1U8L907_GOSHI
AccessioniPrimary (citable) accession number: A0A1U8L907
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: February 28, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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