UniProtKB - A0A1U8DNU4 (A0A1U8DNU4_ALLSI)
Protein
Submitted name:
LOW QUALITY PROTEIN: delta(14)-sterol reductase
Gene
TM7SF2
Organism
Alligator sinensis (Chinese alligator)
Status
Functioni
: cholesterol biosynthesis Pathwayi
This protein is involved in the pathway cholesterol biosynthesis, which is part of Steroid biosynthesis.ARBA annotationView all proteins of this organism that are known to be involved in the pathway cholesterol biosynthesis and in Steroid biosynthesis.
GO - Molecular functioni
- oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor Source: InterPro
GO - Biological processi
- cholesterol biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | OxidoreductaseARBA annotation |
Biological process | Cholesterol biosynthesisARBA annotation, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism |
Enzyme and pathway databases
UniPathwayi | UPA00063 |
Names & Taxonomyi
Protein namesi | Submitted name: LOW QUALITY PROTEIN: delta(14)-sterol reductaseImported |
Gene namesi | Name:TM7SF2Imported |
Organismi | Alligator sinensis (Chinese alligator)Imported |
Taxonomic identifieri | 38654 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Crocodylia › Alligatoridae › Alligatorinae › Alligator |
Proteomesi |
|
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 36 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 56 – 79 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 100 – 121 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 133 – 150 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 259 – 283 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 289 – 308 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 359 – 388 | HelicalSequence analysisAdd BLAST | 30 |
Keywords - Cellular componenti
MembraneFamily & Domainsi
Sequence similaritiesi
Belongs to the ERG4/ERG24 family.ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG1435, Eukaryota |
OrthoDBi | 532774at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR001171, Ergosterol_biosynth_ERG4_ERG24 IPR018083, Sterol_reductase_CS |
Pfami | View protein in Pfam PF01222, ERG4_ERG24, 1 hit |
PROSITEi | View protein in PROSITE PS01017, STEROL_REDUCT_1, 1 hit PS01018, STEROL_REDUCT_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A1U8DNU4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDRYRVPRTK EMEFGGALGT AVLTLLLPGA MWYLLTACGT EEASVLQVPP
60 70 80 90 100
VPAPRILANP QALLLVLGWL GLQAALHMLP MGKVTEGIIL RDKTRLQYRV
110 120 130 140 150
NAFQVLGLTA LGVGAGLAAG LRLSFIHDHL LELAGAATLV AFGLSLLLYL
160 170 180 190 200
KALLASEAAL APGGNSGNPI YDFFMGHELN PRVGSFDLKY FCELRPGLIG
210 220 230 240 250
WVSARVGRSW GGAEIWGQLS SGGWEARGRG XCVPSTPPXP GHAWQEAVLT
260 270 280 290 300
TMDIVHDGFG FMLVFGDLAW VPFTYSLQAY FLVGHPQHLG LPAAVAILLL
310 320 330 340 350
NGLGYYIFRS ANSQKNTFRR NPNDPRVAGL KTIPTATGRR LLASGWWGFV
360 370 380 390 400
RHPNYLGDII MALAWSLPCG LTHMLPYFYV IYFTMLLIHR EARDERQCLR
410 420
KYGLAWEEYC RQVPYRIFPY LY
Sequence databases
RefSeqi | XP_014382006.1, XM_014526520.1 |
Genome annotation databases
GeneIDi | 102376249 |
KEGGi | asn:102376249 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_014382006.1, XM_014526520.1 |
3D structure databases
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 38654.XP_006037178.1 |
Genome annotation databases
GeneIDi | 102376249 |
KEGGi | asn:102376249 |
Organism-specific databases
CTDi | 7108 |
Phylogenomic databases
eggNOGi | KOG1435, Eukaryota |
OrthoDBi | 532774at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00063 |
Family and domain databases
InterProi | View protein in InterPro IPR001171, Ergosterol_biosynth_ERG4_ERG24 IPR018083, Sterol_reductase_CS |
Pfami | View protein in Pfam PF01222, ERG4_ERG24, 1 hit |
PROSITEi | View protein in PROSITE PS01017, STEROL_REDUCT_1, 1 hit PS01018, STEROL_REDUCT_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A1U8DNU4_ALLSI | |
Accessioni | A0A1U8DNU4Primary (citable) accession number: A0A1U8DNU4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2017 |
Last sequence update: | May 10, 2017 | |
Last modified: | February 10, 2021 | |
This is version 15 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |