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Protein
Submitted name:

angiopoietin-1 receptor

Gene

TEK

Organism
Alligator sinensis (Chinese alligator)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorSAAS annotationImported, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
angiopoietin-1 receptorImported
Gene namesi
Name:TEKImported
OrganismiAlligator sinensis (Chinese alligator)Imported
Taxonomic identifieri38654 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaCrocodyliaAlligatoridaeAlligatorinaeAlligator
Proteomesi
  • UP000189705 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei747 – 771HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501053059423 – 1126Sequence analysisAdd BLAST1104

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi242 ↔ 251PROSITE-ProRule annotation
Disulfide bondi331 ↔ 340PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini216 – 252EGF-likeInterPro annotationAdd BLAST37
Domaini307 – 341EGF-likeInterPro annotationAdd BLAST35
Domaini350 – 442Ig-likeInterPro annotationAdd BLAST93
Domaini447 – 541Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini545 – 637Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini642 – 735Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini826 – 1098Protein kinaseInterPro annotationAdd BLAST273

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, Immunoglobulin domainSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

KOiK05121

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 6 hits
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR018941 Tyr_kin_Tie2_Ig-like_dom-1_N
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07974 EGF_2, 1 hit
PF00041 fn3, 3 hits
PF07679 I-set, 1 hit
PF10430 Ig_Tie2_1, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00060 FN3, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1U8DFQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPLAHLLLY GFSLMISGKV EAALDLMLIN SFPLVGNTET SLICIAAKWR
60 70 80 90 100
PCESVTIGRD YEALMSQHQN PLEVTEDEKR GTAKKVVWKR EQAGETIGAY
110 120 130 140 150
YCEGKVKDEV TRIRTMKMSQ RASFLPVALT VTANKGESVN ISFIRKVSKE
160 170 180 190 200
EDAVIYKNGS FIHAVPRHEV PGELEVAYSP VQLQDAGVYY ARYIGGNTFT
210 220 230 240 250
SAYTRLIVRR CEAQKWGPTC SSICPACMNN GICHEDTGEC ICPPGFMGKT
260 270 280 290 300
CEKACEANTF GRTCKESCEE KSGCKYYMFC LPDPYGCSCA TGWRGLECDK
310 320 330 340 350
ECQPGFYGPD CKLRCNCRHQ GSCDRFKGCV CNSGWHGLQC EKEGPADVSP
360 370 380 390 400
QIKSSPGNVE LNSGMEFKPT CRATGEPRPV NEDFKLLKKD GTVLKPNSFL
410 420 430 440 450
TVTQNCSEAT FHIYRVHPPD SGMWVCTVQT VAGEEPFQVT VKVPPVPQYP
460 470 480 490 500
PKMQDSGHNF LIIDINADPH TGDGPIVLTK LLYKPAKGLQ PWKSVKVHGR
510 520 530 540 550
TKKLDNLEPK TEYKFCVQLS RQGDSGEGHP GPEASFTTVA LGLPPPEGLS
560 570 580 590 600
LLPKSRTSLN LSWNPITQKP EDDISIEVEG RNVNDDSDHI VTKVQGNISS
610 620 630 640 650
VIIDKLKPRQ QYMCRVRVNT RSPGEWSDYL YAWTYSDTFP PAPNNIKTCN
660 670 680 690 700
ITDTSVLISW STAEGESISS IIISYKICGK AEYNHIDVTI RNTTITQYHL
710 720 730 740 750
KGLEPNTVYE VELSAQNNVG SSSPNNSVQL KTLPEAKAQH ESKGGKMLLI
760 770 780 790 800
AILGSAGMTC LTILLAFLIM LQLKRANFQH RMAQAFQNVV REEPAVQFNS
810 820 830 840 850
GTLTLSRKAK NSPDPTIYPV LEWNDIKFQD VIGEGNFGQV LKARIKKDGL
860 870 880 890 900
RMDAAIKRMK EYASKDDHRD FAGELEVLCK LGHHPNIINL LGACEHRGYL
910 920 930 940 950
YLAIEYAPHG NLLDFLRKSR VLETDPAFAI ANSTASTLSS QQLLHFAADV
960 970 980 990 1000
ARGMDYLSQK QFIHRDLAAR NILVGENYVA KIADFGLSRG QEVYVKKTMG
1010 1020 1030 1040 1050
RLPVRWMAIE SLNYSVYTTN SDVWSYGVLL WEIVSLGGTP YCGMTCAELY
1060 1070 1080 1090 1100
EKLPQGYRLE KPLNCDDEVY DLMRQCWREK PYERPSFAQI LVSLNRMLEE
1110 1120
RKTYVNTTLY EKFTYAGIDC SAEEAA
Length:1,126
Mass (Da):125,668
Last modified:May 10, 2017 - v1
Checksum:iF7D262D36FBDF3E8
GO

Sequence databases

RefSeqiXP_014376539.1, XM_014521053.1

Genome annotation databases

GeneIDi102376701
KEGGiasn:102376701

Similar proteinsi

Entry informationi

Entry nameiA0A1U8DFQ1_ALLSI
AccessioniPrimary (citable) accession number: A0A1U8DFQ1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: February 28, 2018
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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