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Protein
Submitted name:

desmoglein-3

Gene

DSG3

Organism
Tarsius syrichta (Philippine tarsier)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesionUniRule annotationSAAS annotation
LigandCalciumUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
desmoglein-3Imported
Gene namesi
Name:DSG3Imported
OrganismiTarsius syrichta (Philippine tarsier)Imported
Taxonomic identifieri1868482 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniTarsiiformesTarsiidaeCarlito
Proteomesi
  • UP000189704 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei617 – 639HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501056544424 – 991Sequence analysisAdd BLAST968

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 155CAInterPro annotationAdd BLAST86
Domaini179 – 265CAInterPro annotationAdd BLAST87
Domaini288 – 382CAInterPro annotationAdd BLAST95
Domaini409 – 493CAInterPro annotationAdd BLAST85

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
IPR009123 Desmoglein
IPR009122 Desmosomal_cadherin
PANTHERiPTHR24025 PTHR24025, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 4 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
PR01818 DESMOCADHERN
PR01819 DESMOGLEIN
SMARTiView protein in SMART
SM00112 CA, 4 hits
SUPFAMiSSF49313 SSF49313, 4 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits

Sequencei

Sequence statusi: Complete.

A0A1U7UH47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGIFPRITE ALVILMVVML VHGELRIETK GQHKEDETAV QQAKRRYKRE
60 70 80 90 100
WVKFARPCRE REDNSKRNPI AKITSDYQAN QKITYKISGV GIDQPPFGIF
110 120 130 140 150
VVDPNSGDIN ITAIVDREET PSFLITCRAL NALGQDIEKP LILTVKILDV
160 170 180 190 200
NDNAPVFSQS IFTGEIEENS AANSLVMILN ATDADEPNHQ NSKIAFKIVS
210 220 230 240 250
QEPAGIPMFL LSRNTGEVHT LTNSLDREQV SSYHLVVSGA DRDGEGLSSQ
260 270 280 290 300
CECSIKVKDV NDNFPMLKDS QYSARIEENT LSSELLRFQV IDWDEEYTDN
310 320 330 340 350
WLAVYFFTSG NEGNWFEIQT DPRTNEGILK VVKPLDYEQL QNIQLGIAVK
360 370 380 390 400
NKAEFHQSII SQYRVQSTPV TIQVINVKEG IAFRPASKTF TVQKGISSKK
410 420 430 440 450
LVDYVVGTYQ AIDEETGKAA SYVKYIMGRN NGGFLTIDSK TAEIKFVKNM
460 470 480 490 500
DRDSTFIVNK TITAEILAID GNTGRTSTGT IYVEVPSFNE NCPTIVLEKE
510 520 530 540 550
IICSSSPSVV VSVRTLDRGK YTGPYTFSLE KQPLKLPVVW SITTLNATSA
560 570 580 590 600
LLRAQQEISP GVYRVSLVVT DNQNNICEMP ESLTLEVCQC DNRGICRSYK
610 620 630 640 650
PNRDPEIKYG KPPSGRLGPA AIGLLLLGLL LLLLAPLLLL TCDCGTTGVV
660 670 680 690 700
PGHFIPVPDG SEGTIHQWGI EGAHPQDKEI TNICVPPITT NGGDFMESSE
710 720 730 740 750
VCTNMYAGGT VVEGASGMEM TTKLGAASGS GGAAGFAAGT VSSAAAGFGA
760 770 780 790 800
ATGLGICPAG QSGTMRTRHS TGGTNKDYGN GAISMSFLES YFSQKAFACA
810 820 830 840 850
EEDDNQEAND CLLIYDNEGV DDSDSPLGSL GCCSFIADDL DDSFLDSLGP
860 870 880 890 900
KFKKLAEISL GVDDEATHAQ PRPKDSGYGT EAPQSGSVRC QTLSGSQGTL
910 920 930 940 950
AQQGSGSFQP AVPIPDPLQP GSYLVTGTYS ASGTLVQPST AVFDPLLTQN
960 970 980 990
VTVTERMICP ISSVSGNLAG QTQLRGSRSM LYPEDPCPRP I
Length:991
Mass (Da):107,214
Last modified:May 10, 2017 - v1
Checksum:i9629526AC4B11411
GO

Sequence databases

RefSeqiXP_008071579.1, XM_008073388.1

Genome annotation databases

EnsembliENSTSYT00000012070; ENSTSYP00000011072; ENSTSYG00000012021
GeneIDi103275969

Similar proteinsi

Entry informationi

Entry nameiA0A1U7UH47_TARSY
AccessioniPrimary (citable) accession number: A0A1U7UH47
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: February 28, 2018
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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