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Protein

DNA repair protein REV1

Gene

REV1

Organism
Tarsius syrichta (Philippine tarsier)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, NucleotidyltransferaseUniRule annotation, Transferase
Biological processDNA damage, DNA repairUniRule annotation, DNA synthesisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein REV1UniRule annotation (EC:2.7.7.-UniRule annotation)
Gene namesi
Name:REV1Imported
OrganismiTarsius syrichta (Philippine tarsier)Imported
Taxonomic identifieri1868482 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniTarsiiformesTarsiidaeCarlito
Proteomesi
  • UP000189704 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 131BRCTInterPro annotationAdd BLAST88
Domaini419 – 652UmuCInterPro annotationAdd BLAST234

Sequence similaritiesi

Belongs to the DNA polymerase type-Y family.UniRule annotation

Family and domain databases

CDDicd00027 BRCT, 1 hit
Gene3Di1.20.58.1280, 1 hit
3.30.1490.100, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR036775 DNA_pol_Y-fam_lit_finger_sf
IPR017961 DNA_pol_Y-fam_little_finger
IPR025527 DUF4414
IPR012112 REV1
IPR031991 Rev1_C
IPR038401 Rev1_C_sf
IPR001126 UmuC
PfamiView protein in Pfam
PF16589 BRCT_2, 1 hit
PF14377 DUF4414, 1 hit
PF00817 IMS, 1 hit
PF11799 IMS_C, 1 hit
PF16727 REV1_C, 1 hit
PIRSFiPIRSF036573 REV1, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 1 hit
SUPFAMiSSF100879 SSF100879, 1 hit
SSF52113 SSF52113, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS50173 UMUC, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1U7TNK1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRGGWRKRA ENDGWEKWGG YMAAKVQKLE EQFRSDAAMQ KDGTSSTIFS
60 70 80 90 100
GVAIYVNGYT DPSAEELRKL MMLHGGQYHV YYSRSKTTHI IATNLPNAKI
110 120 130 140 150
KELKGEKVIR PEWIVESIKA GRLLSCIPYQ LYSKQSSVQK GLNFNPVCKP
160 170 180 190 200
EDPVPGPSNI AKQLNNRVNH IIKKIETENE VKVNGMNSWN EEDANNDFGF
210 220 230 240 250
LDLEQTFPGR KQNGIPHSRG STAIFNGHTH SSNGALKTQD CLVPMGNSIA
260 270 280 290 300
SRLSPDSAQE EEKAEQSSTD FRDCTLQQMQ QSSRNADALR NPHRTSSFSL
310 320 330 340 350
SSLHSNTKIN GAHHSTVQGP SSTKSTSSVP TLSKAAPSVP SKPSDCSFIS
360 370 380 390 400
DFYSHSRLHH ISTWKCELTE FVSTLQRQSS GVFPGREKLK KMKTGRSALV
410 420 430 440 450
VTDTGNMSVL SSPRHQSCIM HVDMDCFFVS VGIRNRPDLK GKPVAVTSNR
460 470 480 490 500
GTGRAPLRPG ANPQLEWQYY QNKILKGKAD VPDSSMWDNQ DSAQINGIDS
510 520 530 540 550
VLSKAEIASC SYEARQVGIK NGMFFGHAKQ LCPNLQAVPY DFHAYKEVAR
560 570 580 590 600
TMYETLASYT HNIEAVSCDE ALVDITEILA ETRLTPDEFA NAVRMEIKDQ
610 620 630 640 650
TKCAASVGIG SNILLARMAT RKAKPDGQYH LKPEEVDDFI RGQLVTNLPG
660 670 680 690 700
VGRSMEAKLT SLGIKTCGDL QYMTMAKLQK EFGPKTGQML YRFCRGLDDR
710 720 730 740 750
PVRTEKERKS VSAEINYGIR FTQPKEAEAF LLSLSEEIQR RLETAGMKGK
760 770 780 790 800
RLTLKIMVRK PGAPIETAKF GGHGICDNIA RTVTLDQATD NAKIIGKAAL
810 820 830 840 850
NMFHTMKLNI SDMRGVGIHV NQLVPINLNP STCPSRPPVQ SSHLPGGSHS
860 870 880 890 900
VRDLFQVQKA KKSTEEEHKE VFLAAVDLEM SSASRNCTFL PSFPTHLPAS
910 920 930 940 950
VSPDTSKAES SGKWNGLHSP VSVQSRLNLS IEVPSPSQLD PSVLEALPPD
960 970 980 990 1000
LREQIEQVCA ALGEQGESHS DKRKEPVNGC NTGVLPQPVG AVLLQIPEAQ
1010 1020 1030 1040 1050
DSNVDTGINV IALPAFSQVD PEVFAALPAE LQKELKAAYD QRQRQGENSS
1060 1070 1080 1090 1100
HPQPACAPVP KNPFLQLKPA AVKEKKRNKK KKPVSPLKKI QSPLKNKLLN
1110 1120 1130 1140 1150
SPAKTLPGAC GSPQKLIDGF LKHEGPAAEK PLEELSASTS DVPGLSSLQP
1160 1170 1180 1190 1200
DPAGCARPPA PNLAGAVEFS DVKTLLKEWI TTISDPMEED ILQVVKYCTD
1210 1220 1230 1240 1250
LIEEKDLEKL DLVIKYMKRL MQQSVESVWN MAFDFILDNV QVVLQQTYGS

TLKVT
Length:1,255
Mass (Da):138,193
Last modified:May 10, 2017 - v1
Checksum:i714ECED35303E37C
GO

Sequence databases

RefSeqiXP_008059405.1, XM_008061214.1

Genome annotation databases

GeneIDi103263541

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_008059405.1, XM_008061214.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi103263541

Organism-specific databases

CTDi51455

Family and domain databases

CDDicd00027 BRCT, 1 hit
Gene3Di1.20.58.1280, 1 hit
3.30.1490.100, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR036775 DNA_pol_Y-fam_lit_finger_sf
IPR017961 DNA_pol_Y-fam_little_finger
IPR025527 DUF4414
IPR012112 REV1
IPR031991 Rev1_C
IPR038401 Rev1_C_sf
IPR001126 UmuC
PfamiView protein in Pfam
PF16589 BRCT_2, 1 hit
PF14377 DUF4414, 1 hit
PF00817 IMS, 1 hit
PF11799 IMS_C, 1 hit
PF16727 REV1_C, 1 hit
PIRSFiPIRSF036573 REV1, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 1 hit
SUPFAMiSSF100879 SSF100879, 1 hit
SSF52113 SSF52113, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS50173 UMUC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A1U7TNK1_TARSY
AccessioniPrimary (citable) accession number: A0A1U7TNK1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: March 28, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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