Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA repair protein REV1

Gene

REV1

Organism
Tarsius syrichta (Philippine tarsier)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingUniRule annotation, NucleotidyltransferaseUniRule annotation, Transferase
Biological processDNA damage, DNA repairUniRule annotation, DNA synthesisUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA repair protein REV1UniRule annotation (EC:2.7.7.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:REV1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTarsius syrichta (Philippine tarsier)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1868482 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniTarsiiformesTarsiidaeCarlito
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000189704 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 131BRCTInterPro annotationAdd BLAST88
Domaini419 – 652UmuCInterPro annotationAdd BLAST234

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-Y family.UniRule annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00027 BRCT, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.1280, 1 hit
3.30.1490.100, 1 hit
3.40.50.10190, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR036775 DNA_pol_Y-fam_lit_finger_sf
IPR017961 DNA_pol_Y-fam_little_finger
IPR025527 HUWE1/Rev1_UBM
IPR012112 REV1
IPR031991 Rev1_C
IPR038401 Rev1_C_sf
IPR001126 UmuC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16589 BRCT_2, 1 hit
PF00817 IMS, 1 hit
PF11799 IMS_C, 1 hit
PF16727 REV1_C, 1 hit
PF14377 UBM, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036573 REV1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00292 BRCT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100879 SSF100879, 1 hit
SSF52113 SSF52113, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50172 BRCT, 1 hit
PS50173 UMUC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1U7TNK1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRGGWRKRA ENDGWEKWGG YMAAKVQKLE EQFRSDAAMQ KDGTSSTIFS
60 70 80 90 100
GVAIYVNGYT DPSAEELRKL MMLHGGQYHV YYSRSKTTHI IATNLPNAKI
110 120 130 140 150
KELKGEKVIR PEWIVESIKA GRLLSCIPYQ LYSKQSSVQK GLNFNPVCKP
160 170 180 190 200
EDPVPGPSNI AKQLNNRVNH IIKKIETENE VKVNGMNSWN EEDANNDFGF
210 220 230 240 250
LDLEQTFPGR KQNGIPHSRG STAIFNGHTH SSNGALKTQD CLVPMGNSIA
260 270 280 290 300
SRLSPDSAQE EEKAEQSSTD FRDCTLQQMQ QSSRNADALR NPHRTSSFSL
310 320 330 340 350
SSLHSNTKIN GAHHSTVQGP SSTKSTSSVP TLSKAAPSVP SKPSDCSFIS
360 370 380 390 400
DFYSHSRLHH ISTWKCELTE FVSTLQRQSS GVFPGREKLK KMKTGRSALV
410 420 430 440 450
VTDTGNMSVL SSPRHQSCIM HVDMDCFFVS VGIRNRPDLK GKPVAVTSNR
460 470 480 490 500
GTGRAPLRPG ANPQLEWQYY QNKILKGKAD VPDSSMWDNQ DSAQINGIDS
510 520 530 540 550
VLSKAEIASC SYEARQVGIK NGMFFGHAKQ LCPNLQAVPY DFHAYKEVAR
560 570 580 590 600
TMYETLASYT HNIEAVSCDE ALVDITEILA ETRLTPDEFA NAVRMEIKDQ
610 620 630 640 650
TKCAASVGIG SNILLARMAT RKAKPDGQYH LKPEEVDDFI RGQLVTNLPG
660 670 680 690 700
VGRSMEAKLT SLGIKTCGDL QYMTMAKLQK EFGPKTGQML YRFCRGLDDR
710 720 730 740 750
PVRTEKERKS VSAEINYGIR FTQPKEAEAF LLSLSEEIQR RLETAGMKGK
760 770 780 790 800
RLTLKIMVRK PGAPIETAKF GGHGICDNIA RTVTLDQATD NAKIIGKAAL
810 820 830 840 850
NMFHTMKLNI SDMRGVGIHV NQLVPINLNP STCPSRPPVQ SSHLPGGSHS
860 870 880 890 900
VRDLFQVQKA KKSTEEEHKE VFLAAVDLEM SSASRNCTFL PSFPTHLPAS
910 920 930 940 950
VSPDTSKAES SGKWNGLHSP VSVQSRLNLS IEVPSPSQLD PSVLEALPPD
960 970 980 990 1000
LREQIEQVCA ALGEQGESHS DKRKEPVNGC NTGVLPQPVG AVLLQIPEAQ
1010 1020 1030 1040 1050
DSNVDTGINV IALPAFSQVD PEVFAALPAE LQKELKAAYD QRQRQGENSS
1060 1070 1080 1090 1100
HPQPACAPVP KNPFLQLKPA AVKEKKRNKK KKPVSPLKKI QSPLKNKLLN
1110 1120 1130 1140 1150
SPAKTLPGAC GSPQKLIDGF LKHEGPAAEK PLEELSASTS DVPGLSSLQP
1160 1170 1180 1190 1200
DPAGCARPPA PNLAGAVEFS DVKTLLKEWI TTISDPMEED ILQVVKYCTD
1210 1220 1230 1240 1250
LIEEKDLEKL DLVIKYMKRL MQQSVESVWN MAFDFILDNV QVVLQQTYGS

TLKVT
Length:1,255
Mass (Da):138,193
Last modified:May 10, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i714ECED35303E37C
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_008059405.1, XM_008061214.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
103263541

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_008059405.1, XM_008061214.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi103263541

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51455

Family and domain databases

CDDicd00027 BRCT, 1 hit
Gene3Di1.20.58.1280, 1 hit
3.30.1490.100, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR036775 DNA_pol_Y-fam_lit_finger_sf
IPR017961 DNA_pol_Y-fam_little_finger
IPR025527 HUWE1/Rev1_UBM
IPR012112 REV1
IPR031991 Rev1_C
IPR038401 Rev1_C_sf
IPR001126 UmuC
PfamiView protein in Pfam
PF16589 BRCT_2, 1 hit
PF00817 IMS, 1 hit
PF11799 IMS_C, 1 hit
PF16727 REV1_C, 1 hit
PF14377 UBM, 2 hits
PIRSFiPIRSF036573 REV1, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 1 hit
SUPFAMiSSF100879 SSF100879, 1 hit
SSF52113 SSF52113, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS50173 UMUC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1U7TNK1_TARSY
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1U7TNK1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: December 5, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again