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Entry version 7 (13 Feb 2019)
Sequence version 1 (10 May 2017)
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Protein
Submitted name:

CDK5 regulatory subunit-associated protein 2

Gene

CDK5RAP2

Organism
Tarsius syrichta (Philippine tarsier)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CDK5 regulatory subunit-associated protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDK5RAP2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTarsius syrichta (Philippine tarsier)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1868482 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniTarsiiformesTarsiidaeCarlito
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000189704 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini59 – 129Cnn_1NInterPro annotationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili59 – 79Sequence analysisAdd BLAST21
Coiled coili102 – 129Sequence analysisAdd BLAST28
Coiled coili141 – 176Sequence analysisAdd BLAST36
Coiled coili215 – 242Sequence analysisAdd BLAST28
Coiled coili266 – 311Sequence analysisAdd BLAST46
Coiled coili319 – 363Sequence analysisAdd BLAST45
Coiled coili399 – 433Sequence analysisAdd BLAST35
Coiled coili441 – 472Sequence analysisAdd BLAST32
Coiled coili581 – 625Sequence analysisAdd BLAST45
Coiled coili654 – 674Sequence analysisAdd BLAST21
Coiled coili964 – 991Sequence analysisAdd BLAST28
Coiled coili1216 – 1236Sequence analysisAdd BLAST21
Coiled coili1298 – 1318Sequence analysisAdd BLAST21
Coiled coili1398 – 1432Sequence analysisAdd BLAST35
Coiled coili1494 – 1528Sequence analysisAdd BLAST35
Coiled coili1592 – 1626Sequence analysisAdd BLAST35
Coiled coili1814 – 1844Sequence analysisAdd BLAST31

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Database of Orthologous Groups

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OrthoDBi
1046642at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012943 Cnn_1N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07989 Cnn_1N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1U7TC78-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASVLEEDVT LPGTLSGCSG LVPSIPDDLD GVTPIAGLGS GVLPSVSEET
60 70 80 90 100
VSPTRARNMK DFENQITELK KENFNLKLRI YFLEERMQQE FDGPTEHICK
110 120 130 140 150
TNIELKVEVE SLKRELQERE RLLIKASKAV ESLAVGSGSE IQRVKEDARE
160 170 180 190 200
KMQQVEDLLT KRIRLLEGDV KAAQAELEKA FAGTETEKAL RLNLESKLSE
210 220 230 240 250
MKKMHEGDLK MVLVLEEKDR LIEELKLSLK SKKALIQCLK EEKSQMASPD
260 270 280 290 300
ENASSGELQG LSAALREEKQ RETEAAQMDL QKERNHFEER IQALQEDLRE
310 320 330 340 350
KEMEIATEKK NSLKRDKAIQ GLTMALKSKE KEVEELNSEI KELSSALAKA
360 370 380 390 400
REAAKAREAA EKAQTQKFQA PENCEAALSG NDTLLAELRS ENLTKSTENH
410 420 430 440 450
RLRRNIKKAT QELSDLQEER ERLKKNLEET HREKSQRDCI IHDLRNEVEK
460 470 480 490 500
LRNEVNEREK ALENHYKSLL SESDKKLHSQ EQVIKHLTES TNQKDLLLQK
510 520 530 540 550
LGEKDLEVIQ QNHYLMTAED LKFRSEGLIT EKCSSQLSPS SKIIFSEEKQ
560 570 580 590 600
QSEYEALIQV LKKEQDIYTH LVKTLQESGS INNLQAELNN ISALRKQLEC
610 620 630 640 650
DVLSYRNLQK TLEEQISEIR RREEEPFSFY SDQTSYLSIC LEEHNRFQVE
660 670 680 690 700
HFSQEELKKK VNDLIQLVKE LYTDNQHLKK TIFDLSCMGF QGNDRLASTE
710 720 730 740 750
QTELLASKED EDTIKIGEDD EHNIPSDQHL EQSNEIMEDC SKEGCKNGYL
760 770 780 790 800
RHMESKVLDC NGAHKPGCPG DQSLEEDELM NLLAPFFNEK AMLLLESRPD
810 820 830 840 850
LLKVLWEQIC LTEQEFSGEN LEKTLKKIAI QLRGELGHFV QVNSFSKPCD
860 870 880 890 900
ELKSSREAWL MKAGEVSKVE QKDSSVQTVA MEGDLLRFTH EGNREAWKEK
910 920 930 940 950
STNAVFCAKH QPENLCRTPE RQATPFSFPR MTNRDAKKSR LPILIKPSQS
960 970 980 990 1000
LGSVYCFPAT QDVVAQLQGQ IVELQEELKE FKTQNKQLHQ KLILAEAVME
1010 1020 1030 1040 1050
GRPTPDKMAL NAQPLVGAAY QDSPGEHNGI KTTPSLWRGK EMDSDQQTSY
1060 1070 1080 1090 1100
EIDSEICPSD DLAILPSCKE RSEDFLNPTS VATCVASMSQ PSLKVRVIGT
1110 1120 1130 1140 1150
RQAEDRDTSN DTEHLKQKIL DLETELEGYQ NFISRLQKHS QCSEAIITVL
1160 1170 1180 1190 1200
CGTEGAQDGF GKPKSSANEE EMTFSSLHQV RYVKHMKILH PLAPKMMDSR
1210 1220 1230 1240 1250
LLESLRRQLV EQGYELQKEQ NLNMELFSEI HNLQNKFRDL SQSRYNSLVQ
1260 1270 1280 1290 1300
SQARELSLHR QQIKDGHGIC VIFHERMNTM IKAFEELLQA SDVDCCVAEG
1310 1320 1330 1340 1350
FQEQLNQCAE LLEELEKLFL TGTSVGVEMS TQNELIERIE EDNLTCQHIL
1360 1370 1380 1390 1400
PESPEPSVSH ALSDYETSEK SSFSQDQKQD SDTEKTSVMV NIFSQDLLME
1410 1420 1430 1440 1450
HIQEIRTLRK RLEESIKTNE KLRKQLERQG SEFDQGSTNI FASGSELHSS
1460 1470 1480 1490 1500
LTSEINFLRK QNQALNAMLI KGSQDKQKEN DKLRESLFRK AASLEHLQQA
1510 1520 1530 1540 1550
YASVREENER LQKEVGEKER HNQQLIQEVC SSRQELSRVQ EEVKLGQQLL
1560 1570 1580 1590 1600
SQNDRLLQSL RVELKVYEKL DEEHRRPREA SGEGWKGQDR DLHGLLMEIQ
1610 1620 1630 1640 1650
ALRAQLERSI ENNRTLQSKL EEQLAKGAAK AQEEALTPAI QALSIPEQPP
1660 1670 1680 1690 1700
QLAKDDGDKY PMASENSFDL FDSTHAVTPK SETSLLSGNG TDSFSCVSDS
1710 1720 1730 1740 1750
SATNTPRAPH LVAGYHLWAS KSGCHVLGLI EDYEALSKQI SQGQRLLAEM
1760 1770 1780 1790 1800
DIQTQDACIP SSKELGIKDP HSAPLSRFVT SVSSAKLILE EASRLLKLLW
1810 1820 1830 1840 1850
RVSLPTHGLC TLHCEQIEEM KAEIANLHNK LSEQERKLQN SVKLLQLSKH
1860 1870 1880 1890
QEKVIFDQLV VTHKILRKAR GNLELRPGGV HPATPSPSRP GS
Length:1,892
Mass (Da):215,136
Last modified:May 10, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7D7D7CF56D79BF31
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_008053988.1, XM_008055797.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
103258082

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_008053988.1, XM_008055797.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi103258082

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55755

Phylogenomic databases

OrthoDBi1046642at2759

Family and domain databases

InterProiView protein in InterPro
IPR012943 Cnn_1N
PfamiView protein in Pfam
PF07989 Cnn_1N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1U7TC78_TARSY
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1U7TC78
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: February 13, 2019
This is version 7 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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