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Entry version 13 (16 Oct 2019)
Sequence version 1 (10 May 2017)
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Protein
Submitted name:

protein GREB1

Gene

GREB1

Organism
Tarsius syrichta (Philippine tarsier)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
protein GREB1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GREB1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTarsius syrichta (Philippine tarsier)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1868482 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniTarsiiformesTarsiidaeCarlito
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000189704 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni48 – 82DisorderedSequence analysisAdd BLAST35
Regioni300 – 338DisorderedSequence analysisAdd BLAST39
Regioni1082 – 1139DisorderedSequence analysisAdd BLAST58
Regioni1153 – 1237DisorderedSequence analysisAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1084 – 1128PolyampholyteSequence analysisAdd BLAST45
Compositional biasi1153 – 1168PolarSequence analysisAdd BLAST16
Compositional biasi1182 – 1197PolarSequence analysisAdd BLAST16
Compositional biasi1208 – 1237PolarSequence analysisAdd BLAST30

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
70299at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028422 GREB1

The PANTHER Classification System

More...
PANTHERi
PTHR15720 PTHR15720, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15782 GREB1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1U7T4I0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNSYAGQLK TTRFEEVLHN SIEASLRSNN LVPRPIFSQL YLEAEQQLSS
60 70 80 90 100
LEGGSRADNE EEEEEGEGGL EPSSPPNAYQ LHPPPEGCCT VDGFCQAGKD
110 120 130 140 150
LRLVSIANEP IEVPAGFLLV GAKSPSLPDH LLVCAVDKRF LPDDNGHNAL
160 170 180 190 200
LGFSGNCVGC GKKGFCYFTE FSNHINLKLT TQPKKQKHLK YYLVRNAQGT
210 220 230 240 250
LTKGPLICWK GSEFRSRQAS TSNCSSSFFP PLESSGPLAA FPSEPVPGTN
260 270 280 290 300
PSILMGVQQA GQASDHPTLS AAMGPTVFNG KDSPKHQQLV KNNLSALPRP
310 320 330 340 350
SALGILSNSG PPKKRHKGWS PESPSATDGG YPQGGGNRAK YEGAGMSCMP
360 370 380 390 400
QAGLVGPASV TFPVVASGEP VSVPDNLLKI CKAKPVIFKG HGNFPYLCGN
410 420 430 440 450
LNDVVVSPLL YTCYQNSQSI SRAYEQYGAS AIQPISEEMQ LLLTVYYLVQ
460 470 480 490 500
LAADQVPLME DLEQIFLRSW RESHLTEIRQ YQQAPPQPFP PAPSAAAPVT
510 520 530 540 550
SAQLPWLASL AASSCNDSVH VIECAYSLAE GLSEMFRLLI EGKLAKTNYV
560 570 580 590 600
VIICACRNAA IDSCIAVTGK YQARILSESL LTPAEYQKEV NYELGTGKVD
610 620 630 640 650
SLGAFFSTLC PEGDIDILLD KFHQENQGHI SSSLTASSVT KAVSLDVIGA
660 670 680 690 700
PVCTRYHLEP HSVRPFQLAV AQKLLSHVCS IADSSTQNLD LGSFEKVDFL
710 720 730 740 750
ICIPPSEVTY QQTLFHVWHS GVLLELGLEK EHMTKQRVEQ YVLKLDADAQ
760 770 780 790 800
TKFKAFLQNS FQNPHTLFVL IHDHAHWDVV SSAIHNLYSQ SDPSVGLVDR
810 820 830 840 850
LINCREVKEA PNIVTLHVTS FPYALQTQHT LISPYNEIHW PASYSNGMDL
860 870 880 890 900
YHENKKYFGL SEFIESTLSG HSLPLLRYDS SFEAMVTTLG KRFPRLHSAV
910 920 930 940 950
IRTFVLVQHY AAALMAVSGL PQMKNYTSVE TLEITQNLLN SPKQCPCGHG
960 970 980 990 1000
LMVLLRVPCS PLAAVAYERL AHVRARLALE EHFEIILGNP SSGITVGKHF
1010 1020 1030 1040 1050
VKQLKMWQKI EDAEWRPQTY LELEGLPCIL IFSGMDPHGE SLPRSLRYCD
1060 1070 1080 1090 1100
LRLINSSCLV RTALEQELGL AAYFVSNEAP LEKGPRSEAL ESDAEKLSST
1110 1120 1130 1140 1150
DNEDEELGTE GSTSEKRSPM KRERSCSHDS VSSSLSSKAS GSALCGESLA
1160 1170 1180 1190 1200
QRIGPSQGEQ TRSPQPCGPS EEGRTPGEKP RPQASQGASS AISRHSPSLA
1210 1220 1230 1240 1250
PQPDCGLRTG QRSVQASVTS SSSQLSSSSG SSSSSVAPTA GTLVLQASQC
1260 1270 1280 1290 1300
SMTKTCCQPP VVFLPKLVYD MVVSTDSSGL PKAASLLPSH SVMWASSFRP
1310 1320 1330 1340 1350
LLSKTMTSTE QSLYYRQWTV PRPSHMDYGN RAEGRVDGFH PRRLLLSGPP
1360 1370 1380 1390 1400
QIGKTGAYLQ FLSILSRMLI RLTEVDVYDE EEININLRED SDWHYLQLSD
1410 1420 1430 1440 1450
PWPDLELFKK LPFDYIIHDP KYEDASLICS HHQSIKSEDR GMSRKPEDLF
1460 1470 1480 1490 1500
VRRQTARMRL SKFAAYNTYH HCEQCHQYMG FHPRYQLYES TLHAFAFSYS
1510 1520 1530 1540 1550
MLGEEIQLHF IIPKSKEHHF VFSQPGGQLE SMRLPLVTDK SHEYIKSPTF
1560 1570 1580 1590 1600
TPTTGRHEHG LFNLYHAMDG ASHLHVLVVK EYEMAIYKKY WPNHIMLVLP
1610 1620 1630 1640 1650
SIFNSAGVGA AHFLIKELSY HNLELERNRQ EELGIKPQDI WPFIVISDDS
1660 1670 1680 1690 1700
CVMWNVVDVD CAGERSREFS WSERNVSLKH IMQHIEASPN ITHYALIGLR
1710 1720 1730 1740 1750
KWSSKTQSSE VHEPFSRCHV HDFIILNVDL TQNVQYNQNR FTCDDVDFNL
1760 1770 1780 1790 1800
RVHSAGLLLC RFNRFSVMKK QIAVGGHRSF HITSKVSDNS VAVVPAQYIC
1810 1820 1830 1840 1850
APDSKHTFLA APAQLLLEKF LQHHSHRFFP LSLKNHSHPV LSVDCYLNLG
1860 1870 1880 1890 1900
SQISVCYVSS RPHSLNISCS DLMFSGLLLY LCDSFVGASF LKKFHFLKGA
1910 1920 1930 1940 1950
TLCVICQDRS SLRQTVVRLE LEDEWQFRLR DEFQTANARE DRPLFFLTGR

HI
Length:1,952
Mass (Da):216,928
Last modified:May 10, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3B9AFB8BF1725AB1
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_008048766.1, XM_008050575.1
XP_021564526.1, XM_021708851.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSTSYT00000001231; ENSTSYP00000001139; ENSTSYG00000001231

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
103251978

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_008048766.1, XM_008050575.1
XP_021564526.1, XM_021708851.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSTSYT00000001231; ENSTSYP00000001139; ENSTSYG00000001231
GeneIDi103251978

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9687

Phylogenomic databases

OrthoDBi70299at2759

Family and domain databases

InterProiView protein in InterPro
IPR028422 GREB1
PANTHERiPTHR15720 PTHR15720, 1 hit
PfamiView protein in Pfam
PF15782 GREB1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1U7T4I0_TARSY
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1U7T4I0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: October 16, 2019
This is version 13 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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