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Protein

Claudin

Gene

CLDN4

Organism
Tarsius syrichta (Philippine tarsier)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
ClaudinUniRule annotation
Gene namesi
Name:CLDN4Imported
OrganismiTarsius syrichta (Philippine tarsier)Imported
Taxonomic identifieri1868482 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniTarsiiformesTarsiidaeCarlito
Proteomesi
  • UP000189704 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei79 – 100HelicalUniRule annotationAdd BLAST22
Transmembranei121 – 144HelicalUniRule annotationAdd BLAST24
Transmembranei164 – 183HelicalUniRule annotationAdd BLAST20

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotationSAAS annotation, Membrane, Tight junctionUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003550 Claudin4
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01379 CLAUDIN4
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1U7T1I1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASMGLQVMG VALAVLGWLG VMLSCALPMW RVTAFIGSNI VTSQTIWEGL
60 70 80 90 100
WMNCVVQSTG QMQCKVYDSL LALPQDLQAA RALMVIGIVV AALGVLLSVV
110 120 130 140 150
GGKCTNCVED ESAKAKTMIT AGVVFLLAGL LVMVPVSWTA HNVIRDFYNP
160 170 180 190 200
LVASGQKREM GASLYVGWAA SGLLLLGGGL LCCNCPPRTD KPYSAKYSAA

RSAPASNYV
Length:209
Mass (Da):22,035
Last modified:May 10, 2017 - v1
Checksum:iA6B801DA442025FB
GO

Sequence databases

RefSeqiXP_008053939.1, XM_008055748.1

Genome annotation databases

GeneIDi103258044

Similar proteinsi

Entry informationi

Entry nameiA0A1U7T1I1_TARSY
AccessioniPrimary (citable) accession number: A0A1U7T1I1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: October 25, 2017
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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