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Protein
Submitted name:

MAX gene-associated protein isoform X1

Gene

MGA

Organism
Tarsius syrichta (Philippine tarsier)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation
Biological processTranscription, Transcription regulationSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MAX gene-associated protein isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MGAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTarsius syrichta (Philippine tarsier)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1868482 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniTarsiiformesTarsiidaeCarlito
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000189704 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2427 – 2478BHLHInterPro annotationAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1118 – 1141Sequence analysisAdd BLAST24

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00083 HLH, 1 hit
cd00182 TBOX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.820, 1 hit
4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011598 bHLH_dom
IPR032060 DUF4801
IPR036638 HLH_DNA-bd_sf
IPR037935 MAX_gene-associated_protein
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR001699 TF_T-box
IPR018186 TF_T-box_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11267 PTHR11267, 1 hit
PTHR11267:SF32 PTHR11267:SF32, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16059 DUF4801, 1 hit
PF00010 HLH, 1 hit
PF00907 T-box, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00937 TBOX

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00353 HLH, 1 hit
SM00425 TBOX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47459 SSF47459, 1 hit
SSF49417 SSF49417, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50888 BHLH, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A1U7T115-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEKQQIILA NQDGGTVAGT APTFFVILKQ PGNGKTDQGI LVTNRDACAL
60 70 80 90 100
ASSVSSPGKS KGKICLPADC TVGGITVTLD NNSMWNEFYH RSTEMILTKQ
110 120 130 140 150
GRRMFPYCRY WITGLDSNLK YILVMDISPV DNHRYKWNGR WWEPSGKAEP
160 170 180 190 200
HVLGRVFIHP ESPSTGHYWM HQPVSFYKLK LTNNTLDQEG HIILHSMHRY
210 220 230 240 250
LPRLHLVPAE KAMEVIQLNG PGVHTFTFPQ TEFFAVTAYQ NIQITQLKID
260 270 280 290 300
YNPFAKGFRD DGLNSKPQRD GKQKNNSDQE GNSVPSSPGH RVRLIEDEGS
310 320 330 340 350
EIQPGDLDPI SRGLETSGKG SEKMSLNIKR DFLGFMDTDS ALSEVPQLKQ
360 370 380 390 400
EISESLVANS FEDVCHTASS PLDQNGNFNV VIKEEPLDDY DYDLSECPEG
410 420 430 440 450
VTVKQEETDE ETDVYSNSDD DPILEKQLKR HNKVDNLEAD DLSSKWLPSS
460 470 480 490 500
PSGVAKAKMF KLDTGKMPVV YLEPCAVTKS TVKISELPDN MLSTSRKDKS
510 520 530 540 550
LLAEFEYLPA YIENSSGTGF CLGKESENGF RKHSPDLRVV QKYPLLKELQ
560 570 580 590 600
WNYPDMSDSI NTERILDSSK GSAGDSLSGK EDLSRKRTAM LKIATAPKAG
610 620 630 640 650
NANQNASPNA PGKRGRPRKL KLSKAGRPPR NPGKSLTSTK NTPVGPGSNF
660 670 680 690 700
PDVKPDLEDV DGVLFVCFES KEALDIHAVD ATAEEPSSLQ ASATNDSGCR
710 720 730 740 750
ARISQLEKEL IEDLKSLRHK QVIHPGLQEV GLKLNSVDPA MSIDLKYLGV
760 770 780 790 800
QLPLAPATSF LFWNLTGTNP ASPDAGFPFV SRTGKTNDYT KIKGWRGKFH
810 820 830 840 850
SASASRNEGG NSESSLKNRS AFCSDKLDEY LENEGKLMET SMGFSSNAPT
860 870 880 890 900
SPVVYQLPTK STSYVRTLDS VLKKQSTISP STSYSLKSHS VFPASRKAKS
910 920 930 940 950
QNKQATFSGR TKSSYKSILP YPVSPKQRHS HMVLGEKVTK NSSSTISENQ
960 970 980 990 1000
VNNFVVPTLD ENVFPKQISL RQAHHQQQQQ QQQQGTRPPG LSKSQVKLMD
1010 1020 1030 1040 1050
LEDCALWEGK PRTYITEERA DVSLTTLLTA QASLKTKPIH TIIRKRAPPC
1060 1070 1080 1090 1100
NNDFCRLGCV CSSLALEKRQ PAHCRRPDCM FGCTCLKRKV VLVKGGSRAK
1110 1120 1130 1140 1150
HFQKKAAHRD PIFYDTLGEE AREEEEGVRE EEEHLKEKRK RKKLEYTICE
1160 1170 1180 1190 1200
TEPEQPVQHY PLWVKVEGEV DPEPVYIPTP SVIEPMKPLL LPQPEVLSTT
1210 1220 1230 1240 1250
VKGKLFTGIK SARAYTPKPN PVIREEDKDP VYLYFESMMT CARVRIYERK
1260 1270 1280 1290 1300
KEERRQPSPS PSPSPSFQQQ SSCHSSPENC NAKEPDSEQQ PLKQLTCELE
1310 1320 1330 1340 1350
DDSDKSQEKN WKSSCNEGES SSTSYMHQKS PGGPTKLIEI ISDCNWEEDR
1360 1370 1380 1390 1400
NKILSILSQH INSNMPQSLK VGSFIIELAS QRKSRGEKSP PVYSSRVKIS
1410 1420 1430 1440 1450
MPSCQDQDDM AEKSGSETPD GPLSPGKMDD VSPVQTDALD SVRERLHGGK
1460 1470 1480 1490 1500
GLPFYAGLSP AGKLVAYKRK PSSSTSGLIQ VASNAKVAAS RKPRTLLPST
1510 1520 1530 1540 1550
SNSKTASSSG TTTNRPGKNL KAFVPAKRPI AARPSPGGVF TQFVMSKVGA
1560 1570 1580 1590 1600
LQQKIPGVST PQPLTGPQKF SIRPSPVMVV TPVVSSEPVQ VCSPVTAAVT
1610 1620 1630 1640 1650
TTTPQVLLEN VTAVTPMTAI SDVETKETTY SAGATTTGVV EVSETNVSTP
1660 1670 1680 1690 1700
VTSTQSTATV NLTKTTGITT PVASVAFPKS LVASPPTITL PVASTASTSI
1710 1720 1730 1740 1750
VVVTTAASSS MVTTPTSSLG SVPIILSGIN GSAPVSQRPE NAAQIPVATS
1760 1770 1780 1790 1800
QVSPNTVKRA GPRLLLIPVQ QGSPTLRPVP NTQLQGHRMV LQPIRSPSGM
1810 1820 1830 1840 1850
NLFRHPNGQI VQLLPLHQLR GSNTQPNLQP VMFRNPGSVV GIRLPAPSKP
1860 1870 1880 1890 1900
SETASSSASS SAFSVMNPVI QAVGSSPTVN VITQAPSLLS SGPSFVSQAG
1910 1920 1930 1940 1950
TLTLRISPPE PQNFANKTGS ETKITCSSGG QPAGTASLIP LQSGSFALLQ
1960 1970 1980 1990 2000
LPGQKPVPSS ILQHVASLQM KRESQNVDQK DETNSIKREQ EAKKALHSEG
2010 2020 2030 2040 2050
EAADPESSII KQNSGAAASE ETLHDSLEDE GDHLDEECLT EDSPATVKPS
2060 2070 2080 2090 2100
VHSYITGSHT SEDDKDTNEE CGTRKPCSSK EKLTVLEVRT ISEKASNKTV
2110 2120 2130 2140 2150
QNISKVQLQK LGDVKVEQQK GLDSPKEKSN ELPVISKEES KLELSGSKVV
2160 2170 2180 2190 2200
EQQSNPQLEA KEKGCGDSLE KDSIKERWRK HLKSPLSRKC VGASQECKKE
2210 2220 2230 2240 2250
ADELLTKETK LGQENSDVFQ QEQVISDLFG KSGTTEDVRV SKTECDSWSR
2260 2270 2280 2290 2300
ISNSPTFSIV PRRATKSSRG NGHFQGHLLL PEQLQPKQEM KDGRNSADFT
2310 2320 2330 2340 2350
VLDLEEEDEE DENEKTDDSI DEIVDVVSDY HSEEVDDVEK NNCVAYIEDD
2360 2370 2380 2390 2400
EEQVDIETVE ELSEEINVAH MKTTAAHKQS FKQQCRAHAS ADEKAAERNR
2410 2420 2430 2440 2450
KTSSVPVKLK TDYWNDKLQK EAEAFAYYRR THTANERRRR GEMRDLFEKL
2460 2470 2480 2490 2500
KITLGLLHSS KVSKSLILTR AFSEIQGLTD QADKLIGQKN LLTRKRNILI
2510 2520 2530 2540 2550
RKVSSLSGKT EEVVLKKLEY IYAKQQALEA QKRKKKMGSD EFDMSPRTSK
2560 2570 2580 2590 2600
QQEGSSTSSV DLGQMFINNR RGKPLILSRK RDQATENTSP SNTPPTSANL
2610 2620 2630 2640 2650
VMTPQGQLLT LKGPLFSGPV VTVSPALLEA DLKPQVASSA MAQSENDDLF
2660 2670 2680 2690 2700
MMPRIVNVTS LATEGGLVDM GGSKYSHEVP DGKPPDHLKD TMRNDDNSLE
2710 2720 2730 2740 2750
DSSRISSRAN HRDGRVFLAN KESAFPQIVD VTSMQEAQEF LPKKISGDSR
2760 2770 2780 2790 2800
GIQYKWKESE SRGDRLKSKE SSFHKLKMKD LKDSSIEMEL RKVTSAIEEA
2810 2820 2830 2840 2850
ALDPSELLTN MEDEDDTDET LTSLLNEIAF LNQQLNDDSV SLAELPSSMD
2860 2870 2880 2890 2900
TEFPGDARRA FVSKLPPGNR AAFHVGHLGT GLKELPDVQG DSDSISPLLL
2910 2920 2930 2940 2950
HLEDDDFSEN EKQLAEPASE PDVLKIVIDS EIKDSLHSHK KASDGEKSTS
2960 2970 2980 2990 3000
GLSAEPESGV SSPPILHMKT GLENSSNTDT LWRPMPKLAP LGLKVANPSS
3010 3020 3030 3040 3050
DADGQSLKVM PCLAPIAAKV GSVGHKMNLT GNDQEGRENK MMPTLAPVVA
3060
KLGNTGASPS SAGK
Length:3,064
Mass (Da):335,743
Last modified:May 10, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA69A6868FDFC6BD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1U7SR19A0A1U7SR19_TARSY
MAX gene-associated protein isoform...
MGA
2,855Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_008046617.1, XM_008048426.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
103249801

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_008046617.1, XM_008048426.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi103249801

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23269

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00182 TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR032060 DUF4801
IPR036638 HLH_DNA-bd_sf
IPR037935 MAX_gene-associated_protein
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 1 hit
PTHR11267:SF32 PTHR11267:SF32, 1 hit
PfamiView protein in Pfam
PF16059 DUF4801, 1 hit
PF00010 HLH, 1 hit
PF00907 T-box, 1 hit
PRINTSiPR00937 TBOX
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00425 TBOX, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
SSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1U7T115_TARSY
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1U7T115
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: November 7, 2018
This is version 12 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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