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Protein

Sodium channel protein

Gene

SCN5A

Organism
Tarsius syrichta (Philippine tarsier)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:SCN5AImported
OrganismiTarsius syrichta (Philippine tarsier)Imported
Taxonomic identifieri1868482 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniTarsiiformesTarsiidaeCarlito
Proteomesi
  • UP000189704 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei127 – 149HelicalUniRule annotationAdd BLAST23
Transmembranei253 – 273HelicalUniRule annotationAdd BLAST21
Transmembranei388 – 416HelicalUniRule annotationAdd BLAST29
Transmembranei718 – 736HelicalUniRule annotationAdd BLAST19
Transmembranei748 – 769HelicalUniRule annotationAdd BLAST22
Transmembranei781 – 798HelicalUniRule annotationAdd BLAST18
Transmembranei838 – 861HelicalUniRule annotationAdd BLAST24
Transmembranei881 – 898HelicalUniRule annotationAdd BLAST18
Transmembranei918 – 941HelicalUniRule annotationAdd BLAST24
Transmembranei1207 – 1226HelicalUniRule annotationAdd BLAST20
Transmembranei1247 – 1263HelicalUniRule annotationAdd BLAST17
Transmembranei1275 – 1296HelicalUniRule annotationAdd BLAST22
Transmembranei1324 – 1350HelicalUniRule annotationAdd BLAST27
Transmembranei1428 – 1454HelicalUniRule annotationAdd BLAST27
Transmembranei1513 – 1531HelicalUniRule annotationAdd BLAST19
Transmembranei1543 – 1561HelicalUniRule annotationAdd BLAST19
Transmembranei1573 – 1593HelicalUniRule annotationAdd BLAST21
Transmembranei1630 – 1658HelicalUniRule annotationAdd BLAST29
Transmembranei1733 – 1756HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 422Ion_transInterPro annotationAdd BLAST293
Domaini478 – 667Na_trans_cytoplInterPro annotationAdd BLAST190
Domaini718 – 945Ion_transInterPro annotationAdd BLAST228
Domaini955 – 1202Na_trans_assocInterPro annotationAdd BLAST248
Domaini1206 – 1463Ion_transInterPro annotationAdd BLAST258
Domaini1512 – 1766Ion_transInterPro annotationAdd BLAST255

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili413 – 451Sequence analysisAdd BLAST39

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR008053 Na_channel_a5su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit
PRINTSiPR00170 NACHANNEL
PR01666 NACHANNEL5

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

A0A1U7T0U1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGSATSQ ESREGLPEEE
60 70 80 90 100
VPRPQLDLQA SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK
110 120 130 140 150
TIFRFSATNA LYVLSPFHPI RRAAVKILVH SLFSMLIMCT ILTNCVFMAQ
160 170 180 190 200
HDPPPWTKYV EYTFTAIYTF ESLVKILARG FCLHAFTFLR DPWNWLDFSV
210 220 230 240 250
IVMAYVSENI KLGNLSALRT FRVLRALKTI SVIPGLKTIV GALIQSVKKL
260 270 280 290 300
ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTAVNDT NGSVEADGMV
310 320 330 340 350
WDSLDLYLND PENYLLKNGT SDVLLCGNSS DAGTCPEGYR CLKAGQNPDH
360 370 380 390 400
GYTSFDSFAW AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG
410 420 430 440 450
SFYLVNLILA VVAMAYEEQN QATIAETEEK EKRFQEAMEM LKKEHEALAI
460 470 480 490 500
QGVDTVSRSS LEMSPLAPVT NQEQKSKRKK RLSSGTEECG EDRFPKSDSE
510 520 530 540 550
DGPQAMNHLS LSHGLSRTSV KPRSSRGSIF TFRRRDLGSE TDFADDENST
560 570 580 590 600
AGDSESHRTS LLVPWTLRRT SAPGQPSPGT SAPGFILNGK RNSTVDCNGV
610 620 630 640 650
VSLLGAGDPE TTSPGSHLLH PVMLEHPPDT TTPSEEPGGP PVLTPQVPCV
660 670 680 690 700
DGFEEPGARQ RALSAVSVLT SALEELEESH RKCPPCWNHF AQRYLIWECC
710 720 730 740 750
PLWMSIKQKV KFVVMDPFAD LTITMCIVLN TLFMALEHYN MTIEFEEMLH
760 770 780 790 800
VGNLVFTGIF TAEMTFKIVA LDPYYYFQQG WNIFDSIIVI LSLLELGLSR
810 820 830 840 850
MGNLSVLRSF RLLRVFKLAK SWPTLNTLIK IIGNSVGALG NLTLVLAIIV
860 870 880 890 900
FIFAVVGMQL FGKSYSELRL RINDSDPLPR WHMMDFFHAF LIIFRILCGE
910 920 930 940 950
WIETMWNCME ASGQSLCLLV FLLVMVIGNL VVLNLFLALL LSSFSADNLT
960 970 980 990 1000
APDEDGEMNN LQLALARIQR GLRFVKRTTW DFCCGLMRQQ PQKPAALAAP
1010 1020 1030 1040 1050
GRLPNCIASS SPPPLPEVEK APPARKETRF EEGKPPGQDT PGDLEPVCVP
1060 1070 1080 1090 1100
IAVAESDTDD QEEDEENSLG TEEESSKQQE SQPVSGSPEA PPEPRTWSQV
1110 1120 1130 1140 1150
SETTSSEAEA SASQADWQQQ RKAEPRAPGC SEIHEDSYSE GSTADMTNTA
1160 1170 1180 1190 1200
DLLEQIPDLG EDVKDPEDCF TEGCVRRCPC CAVDTTQAPG KVWWRLRKTC
1210 1220 1230 1240 1250
YRIVEHSWFE TFIIFMILLS SGALAFEDIY LEERKTIKVL LEYADKMFTY
1260 1270 1280 1290 1300
VFVLEMLLKW VAYGFKKYFT NAWCWLDFLI VDVSLISLVA NTLGFAEMGP
1310 1320 1330 1340 1350
IKSLRTLRAL RPLRALSRFE GMRVVVNALV GAIPSIMNVL LVCLIFWLIF
1360 1370 1380 1390 1400
SIMGVNLFAG KFGRCINQTQ GDLPLNYTIV NNKSECESFN VTGELYWTKV
1410 1420 1430 1440 1450
KVNFDNVGAG YLALLQVYEE QPQWEYNLYM YIYFVVFIIF GSFFTLNLFI
1460 1470 1480 1490 1500
GVIIDNFNQQ KKKLGGQDIF MTEEQKKYYN AMKKLGSKKP QKPIPRPLNK
1510 1520 1530 1540 1550
YQGFIFDIVT KQAFDVTIMF LICLNMVTMM VETDDQSPEK VNILAKINLL
1560 1570 1580 1590 1600
FVAIFTGECI VKMAALRHYY FTNSWNIFDF VVVILSIVGT VLSDIIQKYF
1610 1620 1630 1640 1650
FSPTLFRVIR LARIGRILRL IRGAKGIRTL LFALMMSLPA LFNIGLLLFL
1660 1670 1680 1690 1700
VMFIYSIFGM ANFAYVKWEA GIDDMFNFQT FANSMLCLFQ ITTSAGWDGL
1710 1720 1730 1740 1750
LSPILNTGPP YCDPNLLNSN GSRGNCGSPA VGILFFTTYI IISFLIVVNM
1760 1770 1780 1790 1800
YIAIILENFS VATEESTEPL SEDDFDMFYE IWEKFDPEAT QFIEYSALSD
1810 1820 1830 1840 1850
FADALSEPLR IAKPNQISLI NMDLPMVSGD RIHCMDILFA FTKRVLGESG
1860 1870 1880 1890 1900
EMDALKIQME EKFMAANPSK ISYEPITTTL RRKHEEVSAT VIQRAFRRHL
1910 1920 1930 1940 1950
LQRSVKHASF LFRRQTGSSG LSEEDAPERE GLIAYMMNEN FSQPLGPPSS
1960 1970 1980 1990 2000
SSISSTSFPP SYDSVTRATS DNLQVRASDY SPSEDLADFP PSPDRDRESI

V
Length:2,001
Mass (Da):225,367
Last modified:May 10, 2017 - v1
Checksum:iAE67EF188771420D
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1U7TEK1A0A1U7TEK1_TARSY
Sodium channel protein
SCN5A
2,019Annotation score:
A0A1U7TEK6A0A1U7TEK6_TARSY
Sodium channel protein
SCN5A
1,986Annotation score:
A0A1U7TC81A0A1U7TC81_TARSY
Sodium channel protein
SCN5A
2,000Annotation score:
A0A1U7SU63A0A1U7SU63_TARSY
Sodium channel protein
SCN5A
2,018Annotation score:
A0A1U7T4V0A0A1U7T4V0_TARSY
Sodium channel protein
SCN5A
1,965Annotation score:
A0A1U7T4U5A0A1U7T4U5_TARSY
Sodium channel protein
SCN5A
2,018Annotation score:
A0A1U7TC76A0A1U7TC76_TARSY
Sodium channel protein
SCN5A
2,019Annotation score:
A0A1U7SU69A0A1U7SU69_TARSY
Sodium channel protein
SCN5A
1,965Annotation score:

Sequence databases

RefSeqiXP_008051395.1, XM_008053204.1

Genome annotation databases

GeneIDi103255239

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_008051395.1, XM_008053204.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi103255239

Organism-specific databases

CTDi6331

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR008053 Na_channel_a5su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit
PRINTSiPR00170 NACHANNEL
PR01666 NACHANNEL5
ProtoNetiSearch...

Entry informationi

Entry nameiA0A1U7T0U1_TARSY
AccessioniPrimary (citable) accession number: A0A1U7T0U1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: October 10, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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