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Protein

Tyrosine-protein kinase receptor

Gene

Ntrk2

Organism
Mesocricetus auratus (Golden hamster)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotationImported, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:Ntrk2Imported
OrganismiMesocricetus auratus (Golden hamster)Imported
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeMesocricetus
Proteomesi
  • UP000189706 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei432 – 455HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_501081549134 – 823Tyrosine-protein kinase receptorSequence analysisAdd BLAST790

Keywords - PTMi

Disulfide bondSAAS annotation, PhosphoproteinUniRule annotation

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini199 – 284Ig-likeInterPro annotationAdd BLAST86
Domaini539 – 808Protein kinaseInterPro annotationAdd BLAST270

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

Gene3Di2.60.40.10, 2 hits
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR031635 NTRK_C2
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR020455 Tyr_kin_neurotrophic_rcpt_2
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR020777 Tyr_kinase_NGF_rcpt
IPR002011 Tyr_kinase_rcpt_2_CS
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF13855 LRR_8, 1 hit
PF01462 LRRNT, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF16920 TPKR_C2, 1 hit
PRINTSiPR01939 NTKRECEPTOR
PR01941 NTKRECEPTOR2
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00239 RECEPTOR_TYR_KIN_II, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1U7R335-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMLPWPRWH GPAMARLWRL CWLAVGFWRA SLACPVPCKC SASRIWCTEP
60 70 80 90 100
SPGIVAFPRL EPNSVDPENI TEIFIANQKR LEIINEDDVE AYVGLKSLTI
110 120 130 140 150
VDSGLKFVAY KAFLKNSNLQ HVNFTRNKLT SLSRKHFRHL DLSDLVLAGN
160 170 180 190 200
PFTCSCDIMW IKALQETKSS PDTQDLYCLN ESSKNTPLAN LQIPNCGLPS
210 220 230 240 250
ARLAAPNLTV EEGNSITLSC SVAGDPLPTL YWDVGNLVSK HMNETSHTQG
260 270 280 290 300
SLRITNISSD DSGKQISCVA ENLVGEDQDS VNLTVHFAPT ITFLESPTSD
310 320 330 340 350
HHWCIPFTVR GNPKPALQWF YNGAILNESK YICTKIHVTN HTEYHGCLQL
360 370 380 390 400
DNPTHMNNGD YTLMAKNEYG KDERQISAHF MGRPVIDYET NPNYPEDLYE
410 420 430 440 450
DWTAATDIGD TTNKSNEIPS TDVADQTNRE HLSVYAVVVI ASVVGFCLLV
460 470 480 490 500
MLLLLKLARH SKFGMKGPAS VISNDDDSAS PLHHISNGSN TPSSSEGGPD
510 520 530 540 550
AVIIGMTKIP VIENPQYFGI TNSQLKPDTF VQHIKRHNIV LKRELGEGAF
560 570 580 590 600
GKVFLAECYN LCPEQDKILV AVKTLKDASD NARKDFHREA ELLTNLQHEH
610 620 630 640 650
IVKFYGVCVE GDPLIMVFEY MKHGDLNKFL RAHGPDAALM AEGNPPTELT
660 670 680 690 700
QSQMLHIAQQ IAAGMVYLAS QHFVHRDLAT RNCLVGENLL VKIGDFGMSR
710 720 730 740 750
DVYSTDYYRV GGHTMLPIRW MPPESIMYRK FTTESDVWSL GVVLWEIFTY
760 770 780 790 800
GKQPWYQLSN NEVIECITQG RVLQRPRTCP QEVYELMLGC WQREPHMRKS
810 820
IKGIHALLQN LAKASPIYLD VLG
Length:823
Mass (Da):92,291
Last modified:May 10, 2017 - v1
Checksum:iBF0E6AD0BEE791BF
GO

Sequence databases

RefSeqiXP_005078467.1, XM_005078410.1
XP_005078468.1, XM_005078411.1
XP_012974752.1, XM_013119298.1
XP_012974753.1, XM_013119299.1

Genome annotation databases

EnsembliENSMAUT00000019377; ENSMAUP00000015450; ENSMAUG00000014898
GeneIDi101839587

Similar proteinsi

Entry informationi

Entry nameiA0A1U7R335_MESAU
AccessioniPrimary (citable) accession number: A0A1U7R335
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: June 20, 2018
This is version 10 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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