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Protein

DNA polymerase alpha subunit B

Gene

Pola2

Organism
Mesocricetus auratus (Golden hamster)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA replicationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase alpha subunit BUniRule annotation
Gene namesi
Name:Pola2Imported
OrganismiMesocricetus auratus (Golden hamster)Imported
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeMesocricetus
Proteomesi
  • UP000189706 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 239Pol_alpha_B_NInterPro annotationAdd BLAST218
Domaini342 – 549DNA_pol_E_BInterPro annotationAdd BLAST208

Sequence similaritiesi

Belongs to the DNA polymerase alpha subunit B family.UniRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR007185 DNA_pol_alpha/epsilon_bsu
IPR016722 DNA_pol_alpha_bsu
IPR013627 Pol_alpha_B_N
PANTHERiPTHR23061 PTHR23061, 1 hit
PfamiView protein in Pfam
PF04042 DNA_pol_E_B, 1 hit
PF08418 Pol_alpha_B_N, 1 hit
PIRSFiPIRSF018300 DNA_pol_alph_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1U7Q2U4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVSTQQLAE ELQIFGLDCE DSLMEKLAEL CVLYRQTEEG MVSELIAFCT
60 70 80 90 100
STGKMCLTAE ILNSFEHEVL NKKLSKAWHN ASKDSGHAGT RDIVSIQELI
110 120 130 140 150
EVEEEEETLL NSYTTPSKGP HKRASSTPET PLTKRSVSTR SPHQLLSPSS
160 170 180 190 200
FSPSAAPSQK YSSRTNRGEV VTTFGSAQGV SWSGRGSSAG ISLKVIGYPE
210 220 230 240 250
PLTSSYKSMF QQLSDVREVL TCKIEELGSE LKEHYKIEAF TPLLEPAQEP
260 270 280 290 300
VILLGQIGCD SNGKLNSKSV ILEGDREHSS GTQIPVDLSD LKEYSLFPGQ
310 320 330 340 350
VVIMEGFNTT GRRLTATKLY EGVPLPFYQP TEDDADFEQT MVLVACGPYT
360 370 380 390 400
TSDSITYDPL LDLISIINHD RPDVCILFGP FLDAKHEQVE NCQLTSPFED
410 420 430 440 450
VFKQCLRTVI EGTRSSGSQL VFVPSLRDVQ HEPVYPQPPF TFSELPREDK
460 470 480 490 500
KRVQFVSEPC SLSINGVIFG LTSTDLLFHI GAEEICRSSG TSDRFSRILR
510 520 530 540 550
HILTQRSYYP LYPPHEDMAI DYENFYTYAQ MSVTPDVFIV PSELRYFVKD
560 570 580 590 600
ILGCVCMNPG RLTKGQVGGT FGRLYLRRQL RAMDSKGRHG LSVAAQVVRI
Length:600
Mass (Da):66,774
Last modified:May 10, 2017 - v1
Checksum:iD3B6FAB3A7F3F444
GO

Sequence databases

RefSeqiXP_005064024.1, XM_005063967.1

Genome annotation databases

EnsembliENSMAUT00000019715; ENSMAUP00000015785; ENSMAUG00000015136
GeneIDi101825612

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_005064024.1, XM_005063967.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMAUT00000019715; ENSMAUP00000015785; ENSMAUG00000015136
GeneIDi101825612

Organism-specific databases

CTDi23649

Family and domain databases

InterProiView protein in InterPro
IPR007185 DNA_pol_alpha/epsilon_bsu
IPR016722 DNA_pol_alpha_bsu
IPR013627 Pol_alpha_B_N
PANTHERiPTHR23061 PTHR23061, 1 hit
PfamiView protein in Pfam
PF04042 DNA_pol_E_B, 1 hit
PF08418 Pol_alpha_B_N, 1 hit
PIRSFiPIRSF018300 DNA_pol_alph_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A1U7Q2U4_MESAU
AccessioniPrimary (citable) accession number: A0A1U7Q2U4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: June 20, 2018
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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