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Protein

Inosine-5'-monophosphate dehydrogenase

Gene

BU230_11970

Organism
Klebsiella pneumoniae
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

Pathwayi: XMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes XMP from IMP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Inosine-5'-monophosphate dehydrogenase (B4U21_21295), Inosine-5'-monophosphate dehydrogenase (guaB), Inosine-5'-monophosphate dehydrogenase (BU230_11970), Inosine-5'-monophosphate dehydrogenase (CWN54_17340), Inosine-5'-monophosphate dehydrogenase (guaB), Inosine-5'-monophosphate dehydrogenase (guaB), Inosine-5'-monophosphate dehydrogenase (guaB)
This subpathway is part of the pathway XMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes XMP from IMP, the pathway XMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processGMP biosynthesisUniRule annotation, Purine biosynthesis
LigandMetal-bindingUniRule annotation, NADUniRule annotation, PotassiumUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00601; UER00295

Names & Taxonomyi

Protein namesi
Recommended name:
Inosine-5'-monophosphate dehydrogenaseUniRule annotation (EC:1.1.1.205UniRule annotation)
Gene namesi
ORF Names:BU230_11970Imported
OrganismiKlebsiella pneumoniaeImported
Taxonomic identifieri573 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000190740 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 35CBSInterPro annotationAdd BLAST35
Domaini39 – 97CBSInterPro annotationAdd BLAST59

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.UniRule annotation

Keywords - Domaini

CBS domainPROSITE-ProRule annotation

Family and domain databases

CDDicd00381 IMPDH, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR000644 CBS_dom
IPR005990 IMP_DH
IPR015875 IMP_DH/GMP_Rdtase_CS
IPR001093 IMP_DH_GMPRt
PfamiView protein in Pfam
PF00571 CBS, 1 hit
PF00478 IMPDH, 1 hit
SMARTiView protein in SMART
SM00116 CBS, 1 hit
TIGRFAMsiTIGR01302 IMP_dehydrog, 1 hit
PROSITEiView protein in PROSITE
PS51371 CBS, 2 hits
PS00487 IMP_DH_GMP_RED, 1 hit

Sequencei

Sequence statusi: Fragment.

A0A1S9B6A0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RISGVPVVNN LDERKLVGII TNRDMRFIQD YSIKISDVMT KEQLITAPVG
60 70 80 90 100
TTLSEAEKIL QKYKIEKLPL VDNNGVLQGL ITIKDIEKVI EFPNSAKDKQ
110 120 130 140 150
GRLLVGAAVG VTADAMTRID ALVKASVDAI VLDTAHGHSQ GVIDKVKEVR
160 170 180 190 200
AKYPSLNIIA GNVATAEATK ALIEAGANVV KVGIGPGSIC TTRVVAGVGV
210 220 230 240 250
PQLTAVYDCA TEARKHGIPV IADGGIKYSG DMVKALAAGA HVVMLGSMFA
260 270 280 290 300
GVAESPGETE IYQGRQFKVY RGMGSVGAME KGSKDRYFQE GNKKLVPEGI
310 320 330 340 350
EGRVPYKGPL ADTVHQLVGG LRAGMGYCGA QDLEFLRENA QFIRMSGAGL
360
LESHPHHVQI TKEAPNYSL
Length:369
Mass (Da):39,315
Last modified:May 10, 2017 - v1
Checksum:i89CADE3E1E2B9F08
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MTSV01000342 Genomic DNA Translation: OON71285.1

Similar proteinsi

Entry informationi

Entry nameiA0A1S9B6A0_KLEPN
AccessioniPrimary (citable) accession number: A0A1S9B6A0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: August 30, 2017
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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