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Protein

Ribonuclease H

Gene

rnhA

Organism
Agrobacterium fabrum str. J-07
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotationSAAS annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9Magnesium 1UniRule annotation1
Metal bindingi9Magnesium 2UniRule annotation1
Metal bindingi47Magnesium 1UniRule annotation1
Metal bindingi69Magnesium 1UniRule annotation1
Metal bindingi133Magnesium 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonucleaseUniRule annotationSAAS annotation, Hydrolase, Nuclease
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease HUniRule annotationSAAS annotation (EC:3.1.26.4UniRule annotationSAAS annotation)
Short name:
RNase HUniRule annotation
Gene namesi
Name:rnhAUniRule annotationImported
ORF Names:AGR8A_Cc60064Imported
OrganismiAgrobacterium fabrum str. J-07Imported
Taxonomic identifieri1183433 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
Proteomesi
  • UP000191930 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Monomer.UniRule annotationSAAS annotation

Structurei

3D structure databases

SMRiA0A1S7PMN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 141RNase HInterPro annotationAdd BLAST141

Sequence similaritiesi

Belongs to the RNase H family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd09278 RNase_HI_prokaryote_like, 1 hit
Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00042 RNase_H, 1 hit
InterProiView protein in InterPro
IPR012337 RNaseH-like_sf
IPR002156 RNaseH_domain
IPR036397 RNaseH_sf
IPR022892 RNaseHI
PfamiView protein in Pfam
PF00075 RNase_H, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50879 RNASE_H, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1S7PMN8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKHVDIFTDG ACSGNPGPGG WGAVLRYGET EKELSGGEAD TTNNRMELLA
60 70 80 90 100
AISALNALKS PCEVDLYTDS AYVKDGITKW IFGWKKKGWK TADNKPVKNV
110 120 130 140
ELWQALEAAQ ERHKVTLHWV KGHAGHPENE RADELARKGM EPFKRR
Length:146
Mass (Da):16,261
Last modified:May 10, 2017 - v1
Checksum:iCA90796A79057155
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FBWI01000006 Genomic DNA Translation: CUX23814.1
RefSeqiWP_003511799.1, NZ_LT009752.1

Genome annotation databases

GeneIDi31900165

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FBWI01000006 Genomic DNA Translation: CUX23814.1
RefSeqiWP_003511799.1, NZ_LT009752.1

3D structure databases

SMRiA0A1S7PMN8
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi31900165

Family and domain databases

CDDicd09278 RNase_HI_prokaryote_like, 1 hit
Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00042 RNase_H, 1 hit
InterProiView protein in InterPro
IPR012337 RNaseH-like_sf
IPR002156 RNaseH_domain
IPR036397 RNaseH_sf
IPR022892 RNaseHI
PfamiView protein in Pfam
PF00075 RNase_H, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50879 RNASE_H, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A1S7PMN8_9RHIZ
AccessioniPrimary (citable) accession number: A0A1S7PMN8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: November 7, 2018
This is version 9 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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