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Protein

Phosphoribosyl-AMP cyclohydrolase

Gene

hisI

Organism
Agrobacterium tumefaciens str. CFBP 5621
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.UniRule annotationSAAS annotation

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide.UniRule annotationSAAS annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase regulatory subunit (hisZ), ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi92MagnesiumUniRule annotation1
Metal bindingi93Zinc; shared with dimeric partnerUniRule annotation1
Metal bindingi94MagnesiumUniRule annotation1
Metal bindingi96MagnesiumUniRule annotation1
Metal bindingi111Zinc; shared with dimeric partnerUniRule annotation1
Metal bindingi118Zinc; shared with dimeric partnerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Histidine biosynthesisUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayi
UPA00031;UER00008

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosyl-AMP cyclohydrolaseUniRule annotationSAAS annotation (EC:3.5.4.19UniRule annotationSAAS annotation)
Short name:
PRA-CHUniRule annotation
Gene namesi
Name:hisIUniRule annotationImported
ORF Names:AGR4B_Cc60551Imported
OrganismiAgrobacterium tumefaciens str. CFBP 5621Imported
Taxonomic identifieri1183422 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
Proteomesi
  • UP000191855 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 120PRA-CHInterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the PRA-CH family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di3.10.20.400, 1 hit
HAMAPiMF_01021 HisI, 1 hit
InterProiView protein in InterPro
IPR026660 PRA-CH
IPR002496 PRib_AMP_CycHydrolase_dom
IPR038019 PRib_AMP_CycHydrolase_sf
PfamiView protein in Pfam
PF01502 PRA-CH, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002610 PRA_CycHdrlase, 1 hit
SUPFAMiSSF141734 SSF141734, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1S7PB64-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSISFPSAPA DKEVLENAGL FSPKFDAHGL VTAVVTDARD GELLMVAHMN
60 70 80 90 100
AQALSLTLET GIAHYYSRSR DKIWKKGETS GNLQTVKEFR TDCDQDAVWL
110 120 130 140 150
KVSVAGHDAT CHTGRRSCFY RTVELSNGDA VTKITDDTRH FDPATTYSDK
Length:150
Mass (Da):16,528
Last modified:May 10, 2017 - v1
Checksum:iBD93D8393257DABA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FBWF01000007 Genomic DNA Translation: CUX18800.1
RefSeqiWP_020811294.1, NZ_LT009727.1

Similar proteinsi

Entry informationi

Entry nameiA0A1S7PB64_RHIRD
AccessioniPrimary (citable) accession number: A0A1S7PB64
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: February 28, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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