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UniProtKB - A0A1S6LL76 (A0A1S6LL76_STRSQ)

Entry version 10 (03 Jul 2019)
Sequence version 1 (10 May 2017)
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Protein

Urease

Gene

ureAB

Organism
Streptomyces sp.
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).SAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit alpha (ureC2), Urease subunit alpha (ureC2), Urease (ureAB), Urease (ureB), Urease (ureAB), Urease subunit gamma (ureA), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit gamma (ureA), Urease subunit alpha (ureC), Urease (ureAB), Urease subunit gamma/beta (ureAB), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease (ureAB), Urease (ureAB1), Urease subunit alpha (ureC2), Urease (ureAB1), Urease subunit alpha (ureC2), Urease (ureAB), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit beta (ureB), Urease (ureAB), Urease subunit alpha (ureC), Urease (ureC), Urease subunit beta (ureB), Urease (ureAB), Urease subunit alpha (ureC), Urease (ureAB), Urease subunit gamma (ureA), Urease subunit alpha (ureC), Urease subunit alpha (ureC2), Urease subunit gamma (ureAB), Urease subunit gamma (ureA), Urease subunit beta (ureB), Urease subunit alpha (ureC2), Urease subunit alpha (ureC), Urease (ureAB1), Urease subunit alpha (ureC), Urease (ureAB), Urease subunit alpha (ureC), Urease subunit beta (ureB), Urease subunit gamma/beta (ureAB), Urease subunit gamma (ureA), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit alpha (ureC2), Urease subunit gamma (ureAB1), Urease subunit alpha (ureC3), Urease subunit alpha (ureC2), Urease subunit beta (ureB), Urease (ureB), Urease subunit gamma (ureA), Urease subunit gamma (ureA), Urease subunit gamma (ureAB), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit gamma (ureA), Urease (ureA), Urease subunit beta (ureB), Urease subunit alpha (ureC), Urease subunit gamma (DEQ61_23465), Urease subunit gamma (ureA), Urease subunit beta (ureB), Urease subunit gamma (ureAB), Urease subunit beta (ureB), Urease subunit alpha (ureC), Urease (DEQ61_23460), Urease (DEQ61_26695), Urease subunit alpha (ureC2), Urease subunit gamma (ureA), Urease (ureAB1), Urease subunit alpha (ureC2), Urease subunit alpha (ureC2), Urease (DD420_40665), Urease (ureAB), Urease (ureC), Urease (ureAB), Urease subunit alpha (ureC), Urease subunit gamma (ureAB1), Urease (ureAB1), Urease (ureAB), Urease (ureAB), Urease subunit alpha (ureC), Urease (ureAB), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit gamma (ureAB), Urease (ureAB), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease (ureC), Urease subunit beta (ureB), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit beta (ureB), Urease subunit gamma (ureA), Urease subunit alpha (ureC), Urease subunit gamma (ureA), Urease subunit gamma (ureA), Urease (ureB), Urease subunit alpha (ureC), Urease subunit beta (ureB), Urease subunit alpha (ureC), Urease subunit beta (ureB), Urease subunit gamma (ureA), Urease subunit gamma (ureA), Urease subunit beta (ureB), Urease subunit gamma (ureA), Urease subunit alpha (ureC), Urease subunit gamma (ureA), Urease subunit alpha (ureC), Urease (ureAB1), Urease subunit alpha (ureC2), Urease (ureC), Urease (ureC), Urease (ureB), Urease subunit beta (ureB), Urease subunit gamma (ureA), Urease (ureB), Urease subunit alpha (ureC), Urease subunit beta (ureB), Urease subunit gamma (ureA), Urease subunit gamma (ureA), Urease subunit gamma (ureA), Urease subunit gamma (ureA), Urease subunit alpha (ureC), Urease subunit gamma (ureA), Urease subunit gamma (ureA), Urease (ureC), Urease (ureC), Urease subunit gamma (ureAB), Urease subunit alpha (ureC), Urease (ureAB1), Urease (ureAB), Urease (ureAB), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit beta (ureB), Urease subunit beta (ureB), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease (ureAB), Urease subunit alpha (ureC), Urease (ureC), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease (ureAB), Urease subunit alpha (ureC), Urease (ureAB), Urease (ureAB), Urease subunit beta (ureB), Urease subunit gamma (ureA), Urease (ureAB), Urease subunit beta (ureB), Urease subunit beta (ureB), Urease subunit gamma (DD420_10115), Urease (DD420_10110), Urease (ureC), Urease (ureC), Urease subunit gamma (ureA), Urease subunit gamma (ureA), Urease subunit alpha (ureC), Urease (ureAB), Urease subunit alpha (ureC), Urease (ureAB), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit gamma (ureA), Urease subunit alpha (ureC), Urease (ureAB), Urease subunit gamma (ureA), Urease subunit gamma (ureA), Urease subunit gamma (ureA), Urease subunit alpha (ureC), Urease subunit gamma (ureA), Urease subunit gamma (ureA), Urease subunit beta (ureB), Urease subunit alpha (ureC), Urease subunit beta (ureB), Urease subunit beta (ureB), Urease (ureB)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseSAAS annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00258;UER00370

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UreaseSAAS annotation (EC:3.5.1.5SAAS annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ureABImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptomyces sp.Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1931 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces ›

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Family and domain databases

Conserved Domains Database

More...CDDi		cd00407 Urease_beta, 1 hit
cd00390 Urease_gamma, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.10.150.10, 1 hit
3.30.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002019 Urease_beta
IPR036461 Urease_betasu_sf
IPR008223 Urease_gamma-beta_su
IPR002026 Urease_gamma/gamma-beta_su
IPR036463 Urease_gamma_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00699 Urease_beta, 1 hit
PF00547 Urease_gamma, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF001225 Urease_gammabeta, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51278 SSF51278, 1 hit
SSF54111 SSF54111, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00193 urease_gam, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1S6LL76-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLTPTERDR LLLFGAAELA RARRARGLKL NVPEATALIA DTVCEAARDG 
        60         70         80         90        100
RRLAEAIEAA RSVLGPDDVL PGVADVVTEV HVEAVFDDGS RLAVVSRPLG 
       110        120        130        140        150
GGLGDDAPGA VVPGPATPEP EPAARLAVRN TATVPVSVTS HFHFFEANPR 
       160        170        180        190        200
LDFDRAAAYG MRLCVPAGSS VRFGPGESVE VGLVPIGGDR IAIGFAGLVD 
       210        220 
GPLDAPGARE EALRRAVACG YLGAER
Length:226
Mass (Da):23,461
Last modified:May 10, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF8A1574D0A7B9D5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
KY288071 Genomic DNA Translation: AQT38736.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KY288071 Genomic DNA Translation: AQT38736.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Enzyme and pathway databases

UniPathwayiUPA00258;UER00370

Family and domain databases

CDDicd00407 Urease_beta, 1 hit
cd00390 Urease_gamma, 1 hit
Gene3Di2.10.150.10, 1 hit
3.30.280.10, 1 hit
InterProiView protein in InterPro
IPR002019 Urease_beta
IPR036461 Urease_betasu_sf
IPR008223 Urease_gamma-beta_su
IPR002026 Urease_gamma/gamma-beta_su
IPR036463 Urease_gamma_sf
PfamiView protein in Pfam
PF00699 Urease_beta, 1 hit
PF00547 Urease_gamma, 1 hit
PIRSFiPIRSF001225 Urease_gammabeta, 1 hit
SUPFAMiSSF51278 SSF51278, 1 hit
SSF54111 SSF54111, 1 hit
TIGRFAMsiTIGR00193 urease_gam, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1S6LL76_STRSQ
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1S6LL76
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: July 3, 2019
This is version 10 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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