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Entry version 13 (31 Jul 2019)
Sequence version 1 (10 May 2017)
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Protein
Submitted name:

Protein-methionine sulfoxide oxidase

Gene

MICAL1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protein-methionine sulfoxide oxidaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MICAL1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A0A1S5UZH2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini527 – 631Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini686 – 748LIM zinc-bindingInterPro annotationAdd BLAST63
Domaini909 – 1058BMERBInterPro annotationAdd BLAST150

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni746 – 829DisorderedSequence analysisAdd BLAST84
Regioni858 – 877DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili919 – 946Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi767 – 786PolarSequence analysisAdd BLAST20
Compositional biasi793 – 812PolarSequence analysisAdd BLAST20

Keywords - Domaini

Coiled coilSequence analysis, LIM domainPROSITE-ProRule annotationSAAS annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022735 bMERB_dom
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR002938 FAD-bd
IPR036188 FAD/NAD-bd_sf
IPR029937 MICAL1
IPR001781 Znf_LIM

The PANTHER Classification System

More...
PANTHERi
PTHR24206:SF59 PTHR24206:SF59, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 1 hit
PF12130 DUF3585, 1 hit
PF01494 FAD_binding_3, 1 hit
PF00412 LIM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 1 hit
SM00132 LIM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit
SSF51905 SSF51905, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51848 BMERB, 1 hit
PS50021 CH, 1 hit
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1S5UZH2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSCLSHSSLP SCCPPQEASM ASPTSTNPAH AHFESFLQAQ LCQDVLSSFQ
60 70 80 90 100
ELCGALGLEP GGGLPQYHKI KDQLNYWSAK SLWTKLDKRA GQPVYQQGRA
110 120 130 140 150
CTSTKCLVVG AGPCGLRVAV ELALLGARVV LVEKRTKFSR HNVLHLWPFT
160 170 180 190 200
IHDLRALGAK KFYGRFCTGT LDHISIRQLQ LLLLKVALLL GVEIHWGVTF
210 220 230 240 250
TGLQPPPRKG SGWRAQLQPN PPAQLANYEF DVLISAAGGK FVPEGFKVRE
260 270 280 290 300
MRGKLAIGIT ANFVNGRTVE ETQVPEISGV ARIYNQSFFQ SLLKATGIDL
310 320 330 340 350
ENIVYYKDDT HYFVMTAKKQ CLLRLGVLRQ DWPDTNRLLG SANVVPEALQ
360 370 380 390 400
RFTRAAADFA THGKLGKLEF AQDAHGQPDV SAFDFTSMMR AESSARVQEK
410 420 430 440 450
HGARLLLGLV GDCLVEPFWP LGTGVARGFL AAFDAAWMVK RWAEGAESLE
460 470 480 490 500
VLAERESLYQ LLSQTSPENM HRNVAQYGLD PATRYPNLNL RAVTPNQVRD
510 520 530 540 550
LYDVLAKEPV QRNNDKTDTG MPATGSAGTQ EELLRWCQEQ TAGYPGVHVS
560 570 580 590 600
DLSSSWADGL ALCALVYRLQ PGLLEPSELQ GLGALEATAW ALKVAENELG
610 620 630 640 650
ITPVVSAQAV VAGSDPLGLI AYLSHFHSAF KSMAHSPGPV SQASPGTSSA
660 670 680 690 700
VLFLSKLQRT LQRSRAKENA EDAGGKKLRL EAGAGDLCAL CGEHLYVLER
710 720 730 740 750
LCVNGHFFHR SCFRCHTCEA TLWPGGYEQH PGDGHFYCLQ HLPQTDHKAE
760 770 780 790 800
GSDRGPESPE LPTPSENSMP PGLSTPTASQ EGAGPVPDPS QPTRRQIRLS
810 820 830 840 850
SPERQRLSSL NLTPDPEMEP PPKPPRSCSA LARHALESSF VGWGLPVQSP
860 870 880 890 900
QALVAMEKEE KESPFSSEEE EEDVPLDSDV EQALQTFAKT SGTMNNYPTW
910 920 930 940 950
RRTLLRRAKE EEMKRFCKAQ TIQRRLNEIE AALRELEAEG VKLELALRRQ
960 970 980 990 1000
SSSPEQQKKL WVGQLLQLVD KKNSLVAEEA ELMITVQELN LEEKQWQLDQ
1010 1020 1030 1040 1050
ELRGYMNREE NLKTAADRQA EDQVLRKLVD LVNQRDALIR FQEERRLSEL

ALGTGAQG
Length:1,058
Mass (Da):116,842
Last modified:May 10, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i973423FF49EFE507
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KX533483 mRNA Translation: AQN67636.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KX533483 mRNA Translation: AQN67636.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiA0A1S5UZH2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MICAL1 human

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR022735 bMERB_dom
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR002938 FAD-bd
IPR036188 FAD/NAD-bd_sf
IPR029937 MICAL1
IPR001781 Znf_LIM
PANTHERiPTHR24206:SF59 PTHR24206:SF59, 2 hits
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF12130 DUF3585, 1 hit
PF01494 FAD_binding_3, 1 hit
PF00412 LIM, 1 hit
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00132 LIM, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF51905 SSF51905, 1 hit
PROSITEiView protein in PROSITE
PS51848 BMERB, 1 hit
PS50021 CH, 1 hit
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1S5UZH2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1S5UZH2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: July 31, 2019
This is version 13 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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