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Protein
Submitted name:

Pol protein

Gene

pol

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl proteaseUniRule annotation, Hydrolase, Multifunctional enzymeSAAS annotation, Nucleotidyltransferase, Protease, RNA-directed DNA polymeraseSAAS annotation, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Pol proteinImported
Gene namesi
Name:polImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesOrterviralesRetroviridaeOrthoretrovirinaeLentivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 89Peptidase A2InterPro annotationAdd BLAST70
Domaini143 – 333Reverse transcriptaseInterPro annotationAdd BLAST191

Sequence similaritiesi

Belongs to the retroviral Pol polyprotein family.UniRule annotation

Family and domain databases

CDDicd05482 HIV_retropepsin_like, 1 hit
Gene3Di2.40.70.10, 1 hit
3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR001969 Aspartic_peptidase_AS
IPR001995 Peptidase_A2_cat
IPR021109 Peptidase_aspartic_dom_sf
IPR034170 Retropepsin-like_cat_dom
IPR018061 Retropepsins
IPR036397 RNaseH_sf
IPR000477 RT_dom
IPR010659 RVT_connect
IPR010661 RVT_thumb
PfamiView protein in Pfam
PF00077 RVP, 1 hit
PF00078 RVT_1, 1 hit
PF06815 RVT_connect, 1 hit
PF06817 RVT_thumb, 1 hit
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS50175 ASP_PROT_RETROV, 1 hit
PS00141 ASP_PROTEASE, 1 hit
PS50878 RT_POL, 1 hit

Sequencei

Sequence statusi: Fragment.

A0A1S4W0R1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
PQITLWQRPL VSIKVGGQIK EALLDTGADD TVLEEINLPG KWRPKMIGGI
60 70 80 90 100
GGFIKVRQYE QIPIEICGKK AIGTVLVGPT PVNIIGRNML TQLGCTLNFP
110 120 130 140 150
ISPIETVPVK LKPGMDGPKV KQWPLTEEKI KALTAICEEM EKEGKITKIG
160 170 180 190 200
PDNPYNTPIF AIKKKDSTKW RKLVDFRELN KRTQDFWEVQ LGIPHPAGLK
210 220 230 240 250
RKKSVTVLDV GDAYFSVPLD KDFRKYTAFT IPSVNNETPG IRYQYNVLPQ
260 270 280 290 300
GWKGSPAIFQ CSMTKILEPF RKNNPDIVIY QYMDDLYVGS DLEIGQHRTK
310 320 330 340 350
IEELREHLLK WGFTTPDKKH QKEPPFLWMG YELHPDKWTV QPIQLPEKDS
360 370 380 390 400
WTVNDIQKLV GKLNWASQIY PGIKVRQLCK LLRGAKALTE IVPLTEEAEL
410 420 430 440 450
ELAENREILK EPVHGXYYDP SKDLIAEIQK QGQDQWTYQI YQDQFKNLKT
460 470 480 490 500
GKYAKLRTAH TNDVRQLTEA VQKIAMESIV IWGKIPKFRL PIQKETWETW
510 520 530 540 550
WTDYWQATWI PEWEFVNTPP LVKLWYQLEK DPIAGVETFY VDGAANRETK
560
LGKAGYVTDR GRKKNC
Length:566
Mass (Da):65,179
Last modified:April 12, 2017 - v1
Checksum:i860AF08A927DCB8F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei566Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KU050651 Genomic DNA Translation: ALU67446.1

Similar proteinsi

Entry informationi

Entry nameiA0A1S4W0R1_9HIV1
AccessioniPrimary (citable) accession number: A0A1S4W0R1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: July 18, 2018
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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