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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

LOC107799009

Organism
Nicotiana tabacum (Common tobacco)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.UniRule annotation

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 3 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (LOC107828938), Glucose-6-phosphate 1-dehydrogenase (LOC107822069), Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase, chloroplastic, Glucose-6-phosphate 1-dehydrogenase (LOC107794892), Glucose-6-phosphate 1-dehydrogenase (LOC107805957), Glucose-6-phosphate 1-dehydrogenase (LOC107758909), Glucose-6-phosphate 1-dehydrogenase (LOC107831534), Glucose-6-phosphate 1-dehydrogenase (LOC107805957), Glucose-6-phosphate 1-dehydrogenase (G6PDHP2), Glucose-6-phosphate 1-dehydrogenase (LOC107828938), Glucose-6-phosphate 1-dehydrogenase (LOC107786177)
  2. no protein annotated in this organism
  3. 6-phosphogluconate dehydrogenase, decarboxylating (LOC107777046), 6-phosphogluconate dehydrogenase, decarboxylating (LOC107791333), 6-phosphogluconate dehydrogenase, decarboxylating (LOC107799009), 6-phosphogluconate dehydrogenase, decarboxylating (LOC107789656), 6-phosphogluconate dehydrogenase, decarboxylating (LOC107779182)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106NADPUniRule annotation1
Binding sitei106SubstrateUniRule annotation1
Active sitei187Proton acceptorUniRule annotation1
Active sitei194Proton donorUniRule annotation1
Binding sitei195SubstrateUniRule annotation1
Binding sitei265Substrate; via amide nitrogenUniRule annotation1
Binding sitei292SubstrateUniRule annotation1
Binding sitei455Substrate; shared with dimeric partnerUniRule annotation1
Binding sitei461Substrate; shared with dimeric partnerUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 16NADPUniRule annotation6
Nucleotide bindingi34 – 36NADPUniRule annotation3
Nucleotide bindingi78 – 80NADPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processGluconate utilizationUniRule annotation, Pentose shuntUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00115; UER00410

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylatingUniRule annotation (EC:1.1.1.44UniRule annotation)
Gene namesi
Name:LOC107799009Imported
OrganismiNicotiana tabacum (Common tobacco)Imported
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana
Proteomesi
  • UP000084051 Componenti: Genome assembly

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini183 – 4776PGDInterPro annotationAdd BLAST295

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni132 – 134Substrate bindingUniRule annotation3
Regioni190 – 191Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the 6-phosphogluconate dehydrogenase family.UniRule annotation

Phylogenomic databases

KOiK00033

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006114 6PGDH_C
IPR006113 6PGDH_Gnd/GntZ
IPR006115 6PGDH_NADP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR006183 Pgluconate_DH
PfamiView protein in Pfam
PF00393 6PGD, 1 hit
PF03446 NAD_binding_2, 1 hit
PIRSFiPIRSF000109 6PGD, 1 hit
PRINTSiPR00076 6PGDHDRGNASE
SMARTiView protein in SMART
SM01350 6PGD, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00873 gnd, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1S4ALE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPTRIGLA GLAVMGQNLA LNIAEKGFPI SVYNRTTSKV DETVERAKKE
60 70 80 90 100
GDLPLYGFHD PESFVNSIQK PRVIIILVKA GAPVDQTIKT LSAYMEKGDC
110 120 130 140 150
IIDGGNEWYE NTERREKEMA ELGLLYLGMG VSGGEEGARN GPSLMPGGSF
160 170 180 190 200
EAYKYIEDIL LKVAAQVPDS GPCVTYIGKG GSGNFVKMVH NGIEYGDMQL
210 220 230 240 250
IAEAYDVLKS VGKLSNDELQ QVFSEWNKGE LLSFLIEITA DIFGIKDDKA
260 270 280 290 300
DGYLVDKVLD KTGMKGTGKW TVQQAAELSV AAPTIASSLD SRFLSGLKDE
310 320 330 340 350
RVQAAKVFKS SGVSDILVEQ SVDKKQLIDD VRKALYASKV CSYAQGMNLI
360 370 380 390 400
RAKSVEKGWD LKLGELARIW KGGCIIRAIF LDRIKQAYDR NPDLANLLVD
410 420 430 440 450
EEFAKEVVER QSAWRRVVCL AISSGISTPG MSSSLAYFDS YRRERLPANL
460 470 480
VQAQRDYFGA HTYERTDMPG AFHTEWFKIA KQSKI
Length:485
Mass (Da):53,453
Last modified:April 12, 2017 - v1
Checksum:i5311353FABBC0041
GO

Sequence databases

RefSeqiXP_016477550.1, XM_016622064.1
XP_016477551.1, XM_016622065.1
XP_016477552.1, XM_016622066.1

Genome annotation databases

GeneIDi107799009
KEGGinta:107799009

Similar proteinsi

Entry informationi

Entry nameiA0A1S4ALE9_TOBAC
AccessioniPrimary (citable) accession number: A0A1S4ALE9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: March 28, 2018
This is version 10 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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