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Protein

Sodium channel protein

Gene

SCN1A

Organism
Erinaceus europaeus (Western European hedgehog)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:SCN1AImported
OrganismiErinaceus europaeus (Western European hedgehog)Imported
Taxonomic identifieri9365 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeErinaceus
Proteomesi
  • UP000079721 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei124 – 147HelicalUniRule annotationAdd BLAST24
Transmembranei250 – 270HelicalUniRule annotationAdd BLAST21
Transmembranei360 – 379HelicalUniRule annotationAdd BLAST20
Transmembranei399 – 426HelicalUniRule annotationAdd BLAST28
Transmembranei764 – 788HelicalUniRule annotationAdd BLAST25
Transmembranei800 – 821HelicalUniRule annotationAdd BLAST22
Transmembranei841 – 862HelicalUniRule annotationAdd BLAST22
Transmembranei883 – 911HelicalUniRule annotationAdd BLAST29
Transmembranei970 – 996HelicalUniRule annotationAdd BLAST27
Transmembranei1223 – 1241HelicalUniRule annotationAdd BLAST19
Transmembranei1262 – 1281HelicalUniRule annotationAdd BLAST20
Transmembranei1337 – 1365HelicalUniRule annotationAdd BLAST29
Transmembranei1463 – 1487HelicalUniRule annotationAdd BLAST25
Transmembranei1546 – 1564HelicalUniRule annotationAdd BLAST19
Transmembranei1576 – 1594HelicalUniRule annotationAdd BLAST19
Transmembranei1606 – 1626HelicalUniRule annotationAdd BLAST21
Transmembranei1663 – 1691HelicalUniRule annotationAdd BLAST29
Transmembranei1767 – 1790HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini127 – 433Ion_transInterPro annotationAdd BLAST307
Domaini509 – 722Na_trans_cytoplInterPro annotationAdd BLAST214
Domaini773 – 1000Ion_transInterPro annotationAdd BLAST228
Domaini1010 – 1217Na_trans_assocInterPro annotationAdd BLAST208
Domaini1221 – 1495Ion_transInterPro annotationAdd BLAST275
Domaini1545 – 1800Ion_transInterPro annotationAdd BLAST256

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili423 – 468Sequence analysisAdd BLAST46

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR008051 Na_channel_a1su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit
PRINTSiPR00170 NACHANNEL
PR01664 NACHANNEL1

Sequencei

Sequence statusi: Complete.

A0A1S3WX94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQTVLVPPG PDSFNFFTRE SLAAIERRIA EEKAKNPKPD KKDDDENGPK
60 70 80 90 100
PNSDLEAGKN LPFIYGDIPP GMVSEPLEDL DPYYINKKTF IVLNKGKAIF
110 120 130 140 150
RFSATSALYI LTPFNPLRKI AIKILVHSLF SMLIMCTILT NCVFMTMSNP
160 170 180 190 200
PDWTKNVEYT FTGIYTFESL IKIIARGFCI EDFTFLRDPW NWLDFTVITF
210 220 230 240 250
AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL IQSVKKLSDV
260 270 280 290 300
MILTVFCLSV FALIGLQLFM GNLRNKCVQW PPTNASLEEH SIEKNITVDN
310 320 330 340 350
NGTLVNETFT EFDWKSYIQD SRYHYFLEGF LDALLCGNSS DAGQCPEGYV
360 370 380 390 400
CMKAGRNPNY GYTSFDTFSW AFLSLFRLMT QDFWENLYQL TLRAAGKTYM
410 420 430 440 450
IFFVLVIFLG SFYLINLILA VVAMAYEEQN QATMEEAEQK EAEFQQMLEQ
460 470 480 490 500
LKKQQEAAQQ EAVQAAAVTA SEHSKEPSAA GRLSDSSSEV SKLSSKSAKE
510 520 530 540 550
RRNRRKKRKQ KEQSGGEEKD EDEFHKSESE DSIRRKTFPF SIEGNRLTYE
560 570 580 590 600
KRYSSPHQSL LSIRGSIFSP RRNSRTSLFS FRGRAKDVGS ENDFADDEHS
610 620 630 640 650
TFEDNESRRD SLFVPRRHGE RRNSNLSQTS RSSKMLAVFP ANGKMHSTVD
660 670 680 690 700
CNGVVSLVGG PSVPTSPVGQ LLPEVIIDKP ATDDNGTTTE TEMRKRRSSS
710 720 730 740 750
FHVSMDFLED PSQRQRAMSI ASILTNTVEE LEESRQKCPP CWYKFSNIFL
760 770 780 790 800
IWDCSPYWLK VKHIVNLVVM DPFVDLAITI CIVLNTLFMA MEHYPMTDHF
810 820 830 840 850
NNVLTVGNLV FTGIFTAEMF LKIIAMDPYY YFQAGWNIFD GFIVTLSLVE
860 870 880 890 900
LGLADVEGLS VLRSFRLLRV FKLAKSWPTL NMLIKIIGNS VGALGNLTLV
910 920 930 940 950
LAIIVFIFAV VGMQLFGKSY KDCVCKIASD CKLPRWHMND FFHSFLIVFR
960 970 980 990 1000
VLCGEWIETM WDCMEVAGQA MCLTVFMMVM VIGNLVVLNL FLALLLSSFS
1010 1020 1030 1040 1050
ADNLAATDDD NEMNNLQIAV DRMHKGIAYV KRKIYEFIQQ SFVRKKKILD
1060 1070 1080 1090 1100
EIKPLDDLNK RKENCMSNHT AEIGKDLNYL KDVNGTTSGI GTGSTVEKYI
1110 1120 1130 1140 1150
IDESDYMSFI NNPSLTVTVP IAVGESDFEN LNTEDFSSES DLEESKEKLN
1160 1170 1180 1190 1200
ESSSSSEGST VDIGAPAEEQ PVIEPEETLE PEACFTEGCV QRFKCCQVSV
1210 1220 1230 1240 1250
EEGRGKQWWN LRRTCFRIVE HNWFETFIVF MILLSSGALA FEDIYIDQRK
1260 1270 1280 1290 1300
TIKTMLEYAD KVFTYIFILE MLLKWVAYGY QTYFTNAWCW LDFLIVDVSL
1310 1320 1330 1340 1350
VSLTANALGY SELGAIKSLR TLRALRPLRA LSRFEGMRVV VNALLGAIPS
1360 1370 1380 1390 1400
IMNVLLVCLI FWLIFSIMGV NLFAGKFYHC INTTTGDRFE IHEVNNHSDC
1410 1420 1430 1440 1450
IKLIERNESA RWKNVKVNFD NVGFGYLSLL QVATFKGWMD IMYAAVDSRN
1460 1470 1480 1490 1500
VELQPKYEES LYMYLYFVIF IIFGSFFTLN LFIGVIIDNF NQQKKKFGGQ
1510 1520 1530 1540 1550
DIFMTEEQKK YYNAMKKLGS KKPQKPIPRP GNKFQGMVFD FVTRQVFDIS
1560 1570 1580 1590 1600
IMILICLNMV TMMVETDDQS EYVTSVLGRI NLVFIVLFTG ECVLKLISLR
1610 1620 1630 1640 1650
HYYFTIGWNI FDFVVVILSI VGMFLAELIE KYFVSPTLFR VIRLARIGRI
1660 1670 1680 1690 1700
LRLIKGAKGI RTLLFALMMS LPALFNIGLL LFLVMFIYAI FGMSNFAYVK
1710 1720 1730 1740 1750
KEVGIDDMFN FETFGNSMIC LFQITTSAGW DGLLAPILNS GPPDCDPDFN
1760 1770 1780 1790 1800
NPGSSVKGDC GNPSVGIFFF VSYIIISFLV VVNMYIAVIL ENFSVATEES
1810 1820 1830 1840 1850
AEPLSEDDFE MFYEVWEKFD PDATQFMEFE KLSQFAAALE PPLNLPQPNK
1860 1870 1880 1890 1900
LQLIAMDLPM VSGDRIHCLD ILFAFTKRVL GESGEMDALR VQMEERFMAS
1910 1920 1930 1940 1950
NPSKVSYQPI TTTLKRKQEE VSAVIIQRAY RCHLLKRTLK QASFTYNKNK
1960 1970 1980 1990 2000
IKGGANLLVK EDIIIDRINE NSVTEKTDLT MSTAACPPSY DRVTKPIVEK
2010
HEQEGKDEKA KGK
Length:2,013
Mass (Da):229,020
Last modified:April 12, 2017 - v1
Checksum:i88D43F08533ECDEC
GO

Sequence databases

RefSeqiXP_016050799.1, XM_016195313.1

Genome annotation databases

GeneIDi103128492

Similar proteinsi

Entry informationi

Entry nameiA0A1S3WX94_ERIEU
AccessioniPrimary (citable) accession number: A0A1S3WX94
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: February 28, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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