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Protein
Submitted name:

angiopoietin-1 receptor

Gene

TEK

Organism
Erinaceus europaeus (Western European hedgehog)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorSAAS annotationImported, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
angiopoietin-1 receptorImported
Gene namesi
Name:TEKImported
OrganismiErinaceus europaeus (Western European hedgehog)Imported
Taxonomic identifieri9365 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeErinaceus
Proteomesi
  • UP000079721 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei747 – 771HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501020100823 – 1124Sequence analysisAdd BLAST1102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi242 ↔ 251PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini216 – 252EGF-likeInterPro annotationAdd BLAST37
Domaini447 – 541Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini545 – 637Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini642 – 735Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini824 – 1096Protein kinaseInterPro annotationAdd BLAST273

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, Immunoglobulin domainSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 6 hits
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR018941 Tyr_kin_Tie2_Ig-like_dom-1_N
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF10430 Ig_Tie2_1, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00060 FN3, 3 hits
SM00220 S_TKc, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS50026 EGF_3, 1 hit
PS50853 FN3, 3 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1S3WST0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSLAGLVLC GISLLLSGTV DGAMDLILIN SLPLVSDAET SLTCIASGWH
60 70 80 90 100
PHEPITIGRD FEALMNQHQD PLEVTQDATR EWAKKVVWKR EKASKINGAY
110 120 130 140 150
FCEGRVRGDI IRIRTMKMRQ QASFLPATLT MTVDKGDNVN ISFKKVLMKE
160 170 180 190 200
EDAVIYKNGS FIHSVPRHEV PDILEVHLPH AQPQDAGVYS ARYIGGNLFT
210 220 230 240 250
SAFTRLIVRR CEAQKWGPEC NLACTVCMNN GVCHEDTGEC ICPPGFMGRT
260 270 280 290 300
CEKACELHTF GRTCKERCSG PEGCKSYVFC LPDPYGCSCA TGWNGLQCNE
310 320 330 340 350
ACQPGYYGPD CKLKCRCTNG EVCDRFQGCL CSPGRQGLQC EREGMPRMTP
360 370 380 390 400
KIEDLPEHIE VNSGIFNPLC KASGWPLPAK EEMTLVKPDG IVLRPEHFNH
410 420 430 440 450
TGHLSVAQFT LSRILPTDTG VWVCSVNTVA GMVEKPFNIS VKVLPKPLNA
460 470 480 490 500
PNMIDIGHNF AVINISSEPY FGDGPIKSKK LLYKRVNHYE VWQTIQVTNE
510 520 530 540 550
IVTLNYLEPR TDYELCVQLV RRGAGGEGHP GPVRRFTTAS IGLPPPRGLS
560 570 580 590 600
LLPKSQTALN LTWQPVFSSS NDDFYVEVER RSVQVNSDQQ NIKVPGNLTS
610 620 630 640 650
VLLNNLRARE QYVVRARVNT KSQGEWSEDL TAWTLSDVLP PQPKNVKISN
660 670 680 690 700
ITDSSAMITW TILDGFSISS ITIRYKVQGK SEDQHIDVKI KNATITQYQL
710 720 730 740 750
KGLEPETDYL VDIFAENNIG PSNPTFTHEL TTLSRSQVSG DLGSGKLLLI
760 770 780 790 800
AILGSAGMTC LTVLLAFLIM LQLKRANIQR RMAQAFQNVR EEPAVQFNSG
810 820 830 840 850
TLALNRKAKN PDPTIYPVLD WNDIKFQDVI GEGNFGQVLK ARIKKDGLRM
860 870 880 890 900
DAAIKRMKEY ASKDDHRDFA GELEVLCKLG HHPNIINLLG ACEHRGYLYL
910 920 930 940 950
AIEYAPHGNL LDFLRKSRVL ETDPAFAIAN STASTLSSQQ LLHFAADVAR
960 970 980 990 1000
GMDYLSQKQF IHRDLAARNI LVGENYVAKI ADFGLSRGQE VYVKKTMGRL
1010 1020 1030 1040 1050
PVRWMAIESL NYSVYTTNSD VWSYGVLLWE IVSLGGTPYC GMTCAELYEK
1060 1070 1080 1090 1100
LPQGYRLEKP LNCDDEVYDL MRQCWREKPY ERPSFAQILV SLNRMLEERK
1110 1120
TYVNTTLYEK FTYAGIDCSA EEAA
Length:1,124
Mass (Da):125,629
Last modified:April 12, 2017 - v1
Checksum:iC0E195AB2B8B3E38
GO

Sequence databases

RefSeqiXP_016049400.1, XM_016193914.1

Genome annotation databases

GeneIDi103125422

Similar proteinsi

Entry informationi

Entry nameiA0A1S3WST0_ERIEU
AccessioniPrimary (citable) accession number: A0A1S3WST0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: November 22, 2017
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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