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Protein
Submitted name:

receptor-type tyrosine-protein phosphatase delta isoform X1

Gene

PTPRD

Organism
Erinaceus europaeus (Western European hedgehog)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1576Phosphocysteine intermediatePROSITE-ProRule annotation1
Active sitei1867Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseSAAS annotation, ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
receptor-type tyrosine-protein phosphatase delta isoform X1Imported
Gene namesi
Name:PTPRDImported
OrganismiErinaceus europaeus (Western European hedgehog)Imported
Taxonomic identifieri9365 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeErinaceus
Proteomesi
  • UP000079721 Componenti: Genome assembly

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1272 – 1295HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_501022297028 – 1935Sequence analysisAdd BLAST1908

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 121Ig-likeInterPro annotationAdd BLAST91
Domaini133 – 228Ig-likeInterPro annotationAdd BLAST96
Domaini240 – 322Ig-likeInterPro annotationAdd BLAST83
Domaini329 – 419Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini424 – 520Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini522 – 611Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini616 – 713Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini718 – 826Fibronectin type-IIIInterPro annotationAdd BLAST109
Domaini827 – 920Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini925 – 1020Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini1025 – 1111Fibronectin type-IIIInterPro annotationAdd BLAST87
Domaini1380 – 1635Tyrosine-protein phosphataseInterPro annotationAdd BLAST256
Domaini1555 – 1626TYR_PHOSPHATASE_2InterPro annotationAdd BLAST72
Domaini1667 – 1926Tyrosine-protein phosphataseInterPro annotationAdd BLAST260
Domaini1844 – 1917TYR_PHOSPHATASE_2InterPro annotationAdd BLAST74

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

CDDicd00063 FN3, 8 hits
Gene3Di2.60.40.10, 11 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 7 hits
PF07679 I-set, 2 hits
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 8 hits
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
SSF49265 SSF49265, 6 hits
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 8 hits
PS50835 IG_LIKE, 3 hits
PS00383 TYR_PHOSPHATASE_1, 2 hits
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

A0A1S3WDL2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLPSCRMVH VASPLLLLLT FFLRVDAETP PRFTRTPVDQ TGVSGGVASF
60 70 80 90 100
ICQATGDPRP KIVWNKKGKK VSNQRFEVIE FDDGSGSVLR IQPLRTPRDE
110 120 130 140 150
AIYECVASNN VGEISVSTRL TVLREDQIPR GFPTIDMGPQ LKVVERTRTA
160 170 180 190 200
TMLCAASGNP DPEITWFKDF LPVDTSNNNG RIKQLRSGGT PIRGALQIEQ
210 220 230 240 250
SEESDQGKYE CVATNSAGTR YSAPANLYVR ELREVRRVPP RFSIPPTNHE
260 270 280 290 300
IMPGGSVNIT CVAVGSPMPY VKWMLGAEDL TPEDDMPIGR NVLELNDVRQ
310 320 330 340 350
SANYTCVAMS TLGVIEAIAQ ITVKALPKPP GTPIVTESTA TSITLTWDSG
360 370 380 390 400
NPEPVSYYII QHKPKNSEEP YKEIDGVATT RYSVAGLSPY SDYEFRVVAV
410 420 430 440 450
NNIGRGPPSE PVLTQTSEQA PSSAPRDVQA RMLSSTTILV QWKEPEEPNG
460 470 480 490 500
QIQGYRVYYT MDPTQHVNNW MKHNVADSQI TTIGNLVPQK TYSVKVLAFT
510 520 530 540 550
SIGDGPLSSD IQVITQTGVP GQPLNFKAEP ESETSILLSW TPPRSDTIAN
560 570 580 590 600
YELVYKDGDL GEEQRITIEP GTSYRLQGLK PNSLYYFRLA ARSPQGLGAS
610 620 630 640 650
TAEISARTMQ SKPSAPPQDI SCTSPSSTSI LVSWQPPPVE KQNGIITEYS
660 670 680 690 700
IKYTAIDGED DKPREILGIP SDTTKYLLEQ LEKWTEYQIT VTAHTDVGPG
710 720 730 740 750
PESLSVFIRT DEDVPSGPPR KVEVEAVNST SVKVSWRSPV PNKQHGQIRG
760 770 780 790 800
YQVHYVRMEN GEPKGQPMLK DVMLADAQWE FDDTTEHDMI ISGLQPETSY
810 820 830 840 850
SLTVTAYTTK GDGARSKPKL VSTTGAVPGK PRLVINHTQM NTALIQWHPP
860 870 880 890 900
VDIFGPLLGY RLKYGRKDME PLTTLEFSEK EDHFTAIDIH KGASYVFRLS
910 920 930 940 950
ARNKVGFGEE MVKEISVPEE VPSGFPQNLH SEGTTSTTVQ LSWQPPVLAE
960 970 980 990 1000
RNGIITKYTL LYRDINIPLL PMEQLIVPAD TTMTLSGLKP DTTYDVKVRA
1010 1020 1030 1040 1050
YTSKGPGPYS PSVQFRTLPV DQAVFAKNFH VKAVMKTSVL LSWEIPENYN
1060 1070 1080 1090 1100
SAMPFKILYD DGKMVEEVDG RATQKLIVNL KPEKSYSFVL TNRGNSAGGL
1110 1120 1130 1140 1150
QHRVTAKTAP DVLRTKPAFI GKTNLDGMIT VQLPEVPENE NIKGYYIIIV
1160 1170 1180 1190 1200
PLKKSRGKFI KPWESPDEME LDELLKEISR KRRSVRYGRE VELKPYIAAH
1210 1220 1230 1240 1250
FDVLPTEFTL GDDKHYGGFT NKQLQSGQEY VFFVLAVMEH AESKMYATSP
1260 1270 1280 1290 1300
YSDPVVSMDL DPQPITDEEE GLIWVVGPVL AVVFIICIVI AILLYKSKPD
1310 1320 1330 1340 1350
RKRAESDSRK SSIPNSKEVP SHHPTDPVEL RRLNFQTPGS DDSGYRGNLH
1360 1370 1380 1390 1400
SSSMASHPPI PILELADHIE RLKANDNLKF SQEYESIDPG QQFTWEHSNL
1410 1420 1430 1440 1450
EVNKPKNRYA NVIAYDHSRV LLSAIEGIPG SDYVNANYID GYRKQNAYIA
1460 1470 1480 1490 1500
TQGSLPETFG DFWRMIWEQR SATVVMMTKL EERSRVKCDQ YWPTRGTETH
1510 1520 1530 1540 1550
GLVQVTLLDT VELATYCVRT FALYKNGSSE KREVRQFQFT AWPDHGVPEH
1560 1570 1580 1590 1600
PTPFLAFLRR VKTCNPPDAG PMVVHCSAGV GRTGCFIVID AMLERIKHEK
1610 1620 1630 1640 1650
TVDIYGHVTL MRAQRNYMVQ TEDQYIFIHD ALLEAVTCGN TEVPARNLYA
1660 1670 1680 1690 1700
YIQKLTQIET GENVTGMELE FKRLASSKAH TSRFISANLP CNKFKNRLVN
1710 1720 1730 1740 1750
IMPYESTRVC LQPIRGVEGS DYINASFIDG YRQQKAYIAT QGPLAETTED
1760 1770 1780 1790 1800
FWRMLWEHNS TIVVMLTKLR EMGREKCHQY WPAERSARYQ YFVVDPMAEY
1810 1820 1830 1840 1850
NMPQYILREF KVTDARDGQS RTVRQFQFTD WPEQGVPKSG EGFIDFIGQV
1860 1870 1880 1890 1900
HKTKEQFGQD GPISVHCSAG VGRTGVFITL SIVLERMRYE GVVDIFQTVK
1910 1920 1930
MLRTQRPAMV QTEDQYQFCY RAALEYLGSF DHYAT
Length:1,935
Mass (Da):217,163
Last modified:April 12, 2017 - v1
Checksum:iC932204B24D90DF2
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1S2ZUR0A0A1S2ZUR0_ERIEU
receptor-type tyrosine-protein phos...
PTPRD
1,512Annotation score:
A0A1S2ZUQ6A0A1S2ZUQ6_ERIEU
receptor-type tyrosine-protein phos...
PTPRD
1,508Annotation score:
A0A1S3WDL7A0A1S3WDL7_ERIEU
receptor-type tyrosine-protein phos...
PTPRD
1,795Annotation score:
A0A1S3WDH2A0A1S3WDH2_ERIEU
receptor-type tyrosine-protein phos...
PTPRD
1,498Annotation score:
A0A1S3WDA8A0A1S3WDA8_ERIEU
receptor-type tyrosine-protein phos...
PTPRD
1,923Annotation score:
A0A1S3WDB9A0A1S3WDB9_ERIEU
receptor-type tyrosine-protein phos...
PTPRD
1,900Annotation score:
A0A1S3WE25A0A1S3WE25_ERIEU
receptor-type tyrosine-protein phos...
PTPRD
1,502Annotation score:
A0A1S2ZUQ4A0A1S2ZUQ4_ERIEU
receptor-type tyrosine-protein phos...
PTPRD
1,503Annotation score:
A0A1S3WDB3A0A1S3WDB3_ERIEU
receptor-type tyrosine-protein phos...
PTPRD
1,509Annotation score:
A0A1S3WE22A0A1S3WE22_ERIEU
receptor-type tyrosine-protein phos...
PTPRD
1,919Annotation score:

Sequence databases

RefSeqiXP_016044377.1, XM_016188891.1

Genome annotation databases

GeneIDi103115029

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_016044377.1, XM_016188891.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi103115029

Organism-specific databases

CTDi5789

Family and domain databases

CDDicd00063 FN3, 8 hits
Gene3Di2.60.40.10, 11 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 7 hits
PF07679 I-set, 2 hits
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 8 hits
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
SSF49265 SSF49265, 6 hits
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 8 hits
PS50835 IG_LIKE, 3 hits
PS00383 TYR_PHOSPHATASE_1, 2 hits
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA0A1S3WDL2_ERIEU
AccessioniPrimary (citable) accession number: A0A1S3WDL2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: May 23, 2018
This is version 9 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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