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Protein

Mitogen-activated protein kinase kinase kinase kinase

Gene

MAP4K3

Organism
Erinaceus europaeus (Western European hedgehog)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45ATPUniRule annotation1
Active sitei136Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 30ATPUniRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase kinaseUniRule annotation (EC:2.7.11.1UniRule annotation)
Gene namesi
Name:MAP4K3Imported
OrganismiErinaceus europaeus (Western European hedgehog)Imported
Taxonomic identifieri9365 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeErinaceus
Proteomesi
  • UP000079721 Componenti: Genome assembly

Subcellular locationi

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 273Protein kinaseInterPro annotationAdd BLAST258
Domaini569 – 880CNHInterPro annotationAdd BLAST312

Sequence similaritiesi

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.UniRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR001180 CNH_dom
IPR011009 Kinase-like_dom_sf
IPR021160 MAPKKKK
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00780 CNH, 1 hit
PF00069 Pkinase, 1 hit
PIRSFiPIRSF038172 MAPKKKK, 1 hit
SMARTiView protein in SMART
SM00036 CNH, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50219 CNH, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1S3W8K9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPGFDLSRR NPQEDFELIQ RIGSGTYGDV YKARNVNTGE LAAIKVIKLE
60 70 80 90 100
PGEDFAVVQQ EIIMMKDCKH PNIVAYFGSY LRRDKLWICM EFCGGGSLQD
110 120 130 140 150
IYHVTGPLSE LQIAYVSRET LQGLYYLHSK GKMHRDIKGA NILLTDNGHV
160 170 180 190 200
KLADFGVSAQ ITATIAKRKS FIGTPYWMAP EVAAVERKGG YNQLCDLWAV
210 220 230 240 250
GITAIELAEL QPPMFDLHPM RALFLMTKSN FQPPKLKDKL KWSNSFHHFV
260 270 280 290 300
KMALTKNPKK RPTAEKLLQH PFVTQPLTRS LAIELLDKVN NPDHSTYHDF
310 320 330 340 350
DDDDPEPLVA VPHRIHSTSR NVREEKTRSE INFGQVKFDP PLRKETEPHH
360 370 380 390 400
ELPDSDGFLD SSEEIYYTAR SNLDLQLEYG QGHQSSYFLG ANKNCILYNE
410 420 430 440 450
SLARSLLKSV EEELHQRGHV AHLEDEEGDD EDSKHSTMKA KVPPPLPPKP
460 470 480 490 500
KSIFIPQETH STEDDNQGTI KRCPTSESPA KPSQVPPRPP PPRLPPQKPI
510 520 530 540 550
TITLGNGVNS FQLNGERDGS LYQQQNEHRD TNPSRKEKKD VPKPISNGLP
560 570 580 590 600
PTPKVHMGAC FSKVFNGCPL KIHCATSWIN PDTRDQYLIF GAEEGIYTLN
610 620 630 640 650
LNELHETSME QLFPRRCTWL YVMNNCLLSI SGKASQLYSH NLPGLFDYAR
660 670 680 690 700
QMQKLPVSIP AHKLPDRILP RKFAVSAKIP ETKWCQKCCV VRNPYTGHKY
710 720 730 740 750
LCGALQTSIV LLEWVEPMQK FMLIKRVDFP IPCPLRMFEM LVVPEQEYPL
760 770 780 790 800
VCVGVGRGRD FNQVVRFETI NPNSTSSWFT ESDTPQASVT HVTQLERDTI
810 820 830 840 850
LVCLDCCIKI VNLQGRLKSS RKLSSELTFD FQIESIVCLQ DSVLAFWKHG
860 870 880 890 900
MQGRSFRSNE VTQEISDSTR IFRLLGSDRV VVLESRPTDN PTANSNLYIL

AGHENSY
Length:907
Mass (Da):102,917
Last modified:April 12, 2017 - v1
Checksum:i1F35B2AEB95EEB25
GO

Sequence databases

RefSeqiXP_016042706.1, XM_016187220.1

Genome annotation databases

GeneIDi103111654

Similar proteinsi

Entry informationi

Entry nameiA0A1S3W8K9_ERIEU
AccessioniPrimary (citable) accession number: A0A1S3W8K9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: November 22, 2017
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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