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Protein

RNA polymerase II transcription factor B subunit 2

Gene

LOC106765355

Organism
Vigna radiata var. radiata (Mung bean) (Phaseolus aureus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
Name:LOC106765355Imported
OrganismiVigna radiata var. radiata (Mung bean) (Phaseolus aureus)Imported
Taxonomic identifieri3916 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeVigna
Proteomesi
  • UP000087766 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

KOiK03144

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1S3UHB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEVRIIAKN FMDMVASMPA MKLDKLYENG FICEAILRSL PPLAKKYVIQ
60 70 80 90 100
MLQIDVPVAA KLLEEWVLPD GLSKHRVAID RLVQLRVFLE AVDRKNEKTY
110 120 130 140 150
KVNPTYQRSL QKLLVQGGTL PRESMPSNIT VRLPTLENLE AYALEQWECF
160 170 180 190 200
LLQLISPSQV DKPLNISSSL MKLFQRRLLS HRDKEAPKLT ESGFQFLLMD
210 220 230 240 250
TNAQLWYIIR EYISNSEERG VDAADLISFM LELSFHVIGE AYSINTLTDF
260 270 280 290 300
QRSIINDLAD LGLVKLQQGR KGSWFIPTKL ATNLSMSLAD SSSRKQGFVV
310 320 330 340 350
VETNFRVYAY STSKLHCEIL RLFSRVEYQL PNLIVGAITK ESLYNAFENG
360 370 380 390 400
ITADQIVTFL QQNAHPRVAE RIPSVPENVT DQIRLWEADL NRVEMTDAYY
410 420 430 440 450
YDEFPSRDVF EGACDCAREW NGLLWEDSKK MHMVVKTEVH PYVRDYLRRQ

K
Length:451
Mass (Da):52,032
Last modified:April 12, 2017 - v1
Checksum:i1B42FA385F84E260
GO

Sequence databases

RefSeqiXP_014505423.1, XM_014649937.1

Genome annotation databases

GeneIDi106765355
KEGGivra:106765355

Similar proteinsi

Entry informationi

Entry nameiA0A1S3UHB6_VIGRR
AccessioniPrimary (citable) accession number: A0A1S3UHB6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: February 28, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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