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Entry version 21 (10 Feb 2021)
Sequence version 1 (12 Apr 2017)
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Protein
Submitted name:

pro-epidermal growth factor isoform X1

Gene

egf

Organism
Salmo salar (Atlantic salmon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
pro-epidermal growth factor isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:egfImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmo salar (Atlantic salmon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8030 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000087266 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1048 – 1071HelicalSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501023748423 – 1198Sequence analysisAdd BLAST1176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi999 ↔ 1016PROSITE-ProRule annotation
Disulfide bondi1018 ↔ 1027PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati86 – 127LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Repeati128 – 169LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Repeati170 – 212LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati213 – 258LDL-receptor class BPROSITE-ProRule annotationAdd BLAST46
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini352 – 392EGF-likeInterPro annotationAdd BLAST41
Repeati479 – 519LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Repeati520 – 562LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati563 – 605LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati606 – 649LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati650 – 692LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Domaini840 – 878EGF-likeInterPro annotationAdd BLAST39
Domaini879 – 920EGF-likeInterPro annotationAdd BLAST42
Domaini921 – 961EGF-likeInterPro annotationAdd BLAST41
Domaini987 – 1028EGF-likeInterPro annotationAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni781 – 826DisorderedSequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi783 – 802PolarSequence analysisAdd BLAST20

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
1174178at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR000033, LDLR_classB_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07645, EGF_CA, 3 hits
PF00058, Ldl_recept_b, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 9 hits
SM00179, EGF_CA, 5 hits
SM00135, LY, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184, SSF57184, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 3 hits
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 5 hits
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 2 hits
PS51120, LDLRB, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A1S3SSV5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVVTVAAVL VYFSVQNDGA SAAPGKACWL VDPSGVGNGS CVAPEPYLIF
60 70 80 90 100
GHGKAIYRMD LDGGNQKRVV TGVGNSILLD FHYTEGRVYW ADKKTGVIYK
110 120 130 140 150
AAMDGTQRQK LHSSEKGISG LAVDWVHNFV IWTSGEVGSI KRVDTDGKNE
160 170 180 190 200
RTLLRHLSQP ISIAVAPNDR FIFWLSDGIT PSIQRSDVAG EMITTVLKIP
210 220 230 240 250
ERLGGLSVDR TDKRLFWVQF SLEGESAIGS CDYNGNVVNV IDQPLLSQSL
260 270 280 290 300
GMSVFLEQVY YTDMSSRTIR QVNKYSGVEA ENINLKRMTH PSTAVKVVHP
310 320 330 340 350
LSQPIEDSMP VFPACDGRTG VCVNVCSNPA EQGICQCTKG FALSKHGNYC
360 370 380 390 400
EDVNECGLWD HGCSLGCENI PGSYFCTCPK GYALLPDRKT CQETSPCLAN
410 420 430 440 450
MTQCDNGCLA TDEGTICVCP EGSILQPDGQ TCRGCSSSDR GGCSQQCSPI
460 470 480 490 500
TPGRWECDCL PGYKIHQDGK RCTATGPPPY LLFANIVNIR RVNLDGTGDQ
510 520 530 540 550
SLVEEPRGTV IALDYDPVQN KVYFASTVLK QIERADLDGG SREVLLTEGL
560 570 580 590 600
DSPEGLAVDW VNRKLYWTDR GLSTIDRSTL DGFDRETIIS KGIQKPRGIA
610 620 630 640 650
VHPLAKKLFW TDMGTRPVLE SASLEGSDRA VIASTDLVSP SGLTIDFTED
660 670 680 690 700
RLYWCDSQRG VLEMASLDGS NRQVLTENEV GRPFDLVVFE DRLWITDREQ
710 720 730 740 750
QLLLSVDKRT GMNPERLHGN MVQPASIVVV HPLAKPGANV CLYQNGGCAQ
760 770 780 790 800
VCESRLGFAH CSCHSHIAQS ADGKDCLPSY GSTDSGDGES ADPFSLKNKT
810 820 830 840 850
LNDESMPLPV PGLSTDGEEA EDNLDEGSEP TLFIEKMVSD QDDCFSLRCD
860 870 880 890 900
VNAQCLLDGG NPTCHCLEGF TGDGELCVDL DECMLGMTLC SIQSSVCVNT
910 920 930 940 950
AGGYYCQCRP GFSGEEHHCT DIDECKMGTH KCDERAECIN TIGKYRCKCQ
960 970 980 990 1000
AGYSGNGHTC QELSTTSSWV TTSRPMDVTS QWLNTNTVES CPSSHDTYCL
1010 1020 1030 1040 1050
YEGVCFYFPE MESYACNCIS GYMGERCQFS DLEWWELQQA EQEKRRNVAI
1060 1070 1080 1090 1100
ALGMVVLITL LSIAACVTYC YGSRRFIRKH PSVDDMSETS TSDDTMSETT
1110 1120 1130 1140 1150
VPKTPRFYVV LEHGGDGKVI HVMGSPRRVV CPSCSSETGE SFVSEEVVTL
1160 1170 1180 1190
PRLNKGYECS FGLATMETNK TGANHLKSID NLIFLDDPQP VSAIPQLT
Length:1,198
Mass (Da):130,988
Last modified:April 12, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD8C503D21F5CD9A7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1S3SSW2A0A1S3SSW2_SALSA
pro-epidermal growth factor isoform...
egf
1,196Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1S3SSV7A0A1S3SSV7_SALSA
pro-epidermal growth factor isoform...
egf
1,168Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_014067426.1, XM_014211951.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSAT00000130565; ENSSSAP00000096201; ENSSSAG00000072853

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
106611584

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sasa:106611584

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_014067426.1, XM_014211951.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSSSAT00000130565; ENSSSAP00000096201; ENSSSAG00000072853
GeneIDi106611584
KEGGisasa:106611584

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1950

Phylogenomic databases

OrthoDBi1174178at2759

Family and domain databases

Gene3Di2.120.10.30, 2 hits
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR000033, LDLR_classB_rpt
PfamiView protein in Pfam
PF07645, EGF_CA, 3 hits
PF00058, Ldl_recept_b, 4 hits
SMARTiView protein in SMART
SM00181, EGF, 9 hits
SM00179, EGF_CA, 5 hits
SM00135, LY, 9 hits
SUPFAMiSSF57184, SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 3 hits
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 5 hits
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 2 hits
PS51120, LDLRB, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1S3SSV5_SALSA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1S3SSV5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: February 10, 2021
This is version 21 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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