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Entry version 14 (17 Jun 2020)
Sequence version 1 (12 Apr 2017)
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Protein
Submitted name:

collagen alpha-1(I) chain

Gene

LOC100286406

Organism
Salmo salar (Atlantic salmon)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
collagen alpha-1(I) chainImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC100286406Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmo salar (Atlantic salmon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8030 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000087266 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
12212 Sal s 6
12213 Sal s 6.0101

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501036350923 – 1449Sequence analysisAdd BLAST1427

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 89VWFCInterPro annotationAdd BLAST59
Domaini1214 – 1449Fibrillar collagen NC1InterPro annotationAdd BLAST236

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni95 – 1185DisorderedSequence analysisAdd BLAST1091

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi124 – 141Pro-richSequence analysisAdd BLAST18
Compositional biasi167 – 184Pro-richSequence analysisAdd BLAST18
Compositional biasi1161 – 1178Pro-richSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

CollagenImported, SignalSequence analysis

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K06236

Database of Orthologous Groups

More...
OrthoDBi
337699at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR000885 Fib_collagen_C
IPR001007 VWF_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 7 hits
PF00093 VWC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00038 COLFI, 1 hit
SM00214 VWC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51461 NC1_FIB, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1S3S6G4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSFVDIRLA LLLSATVLLA RGQGEDDRTA GSCTLDGQFY NDRDVWKPEP
60 70 80 90 100
CQICVCDSGT VMCDEVICED TSDCPNPVIP HDECCPICPD DGFQEPKVEG
110 120 130 140 150
PQGDRGAKGE PGPAGFPGND GIPGQPGLPG PPGPPGPPGL GGNFSPQMSG
160 170 180 190 200
GFDEKSGGGM SMPGPMGPMG PRGPPGPPGS SGPQGFTGPP GEPGEAGSSG
210 220 230 240 250
PMGPRGPAGP PGKNGDDGES GKPGRPGERG ASGPQGARGF PGTPGLPGIK
260 270 280 290 300
GHRGFSGLDG AKGESGPAGP KGEAGASGEN GAAGAMGPRG LPGERGRAGP
310 320 330 340 350
NGAAGARGND GAAGAAGPPG PTGPAGAPGF PGGPGAKGEV GAQGARGGEG
360 370 380 390 400
PQGSRGEAGN PGPAGAAGPA GNNGADGNPG TKGAPGSSGI AGAPGFPGPR
410 420 430 440 450
GPPGPQGAGG APGPKGNTGE VGATGAKGEA GAKGESGPAG VQGPAGPAGE
460 470 480 490 500
EGKRGGRGEP GSAGARGAPG ERGAPGSRGF PGSDGAAGPK GGPGERGGAG
510 520 530 540 550
VAGAKGNTGE PGRNGEPGMP GSKGMTGSPG SPGPDGKTGP SGAGGQDGRP
560 570 580 590 600
GPPGPVGARG QPGVMGFPGP KGAAGEGGKP GERGVMGPVG AVGAPGKDGD
610 620 630 640 650
VGAPGAPGAA GPSGERGEQG AGGPPGFQGL PGPQGAIGET GKPGEQGLPG
660 670 680 690 700
EGGAPGAAGS RGDRGFPGER GAPGPSGPAG ARGSPGSAGN DGAKGEAGAA
710 720 730 740 750
GAPGGQGPPG LQGMPGERGA GGLPGLKGDR GDQGVKGADG AGGKDGIRGM
760 770 780 790 800
TGPIGPNGPA GSPGDKGETG APGPGGPTGA RGAPGERGES GAPGPAGFAG
810 820 830 840 850
PPGGDGQPGA KGEAGDNGAK GDGGAQGPAG PTGAPGPQGP AGNTGAKGAR
860 870 880 890 900
GAAGPPGATG FPGAAGRVGP PGPSGNNGPP GPPGPGGKEG QKGNRGETGP
910 920 930 940 950
SGRPGELGAA GPPGAQGEKG QPGADGPNGP AGTPGPQGIG GQRGIVGLPG
960 970 980 990 1000
QRGERGFPGL PGQLGEPGKQ GPGGPSGERG PPGPMGPPGL AGAPGESGRE
1010 1020 1030 1040 1050
GTPGNEGSSG RDGAAGPKGE RGESGAAGAS GAPGPPGAPG PVGPAGKSGD
1060 1070 1080 1090 1100
RGESGPAGPA GIAGPAGPRG PSGPAGARGD KGEAGEAGER GMKGHRGFTG
1110 1120 1130 1140 1150
MQGPSGPAGP SGESGPAGAS GPAGPRGPSG SAGAAGKDGM SGLPGPIGPP
1160 1170 1180 1190 1200
GPRGRSGEMG PSGPPGPPGP PGPPGPPGGG FDMGFIAQPA QEKAPDPFRH
1210 1220 1230 1240 1250
FRADDANVMR DRDLEVDTTL KSLSQQIENI RSPEGTKKNP ARTCRDLKMC
1260 1270 1280 1290 1300
HPDWKSGEYW IDPDQGCTQD AIKVYCNMET GETCVYPTEA EIPKKSWYTS
1310 1320 1330 1340 1350
KNIKEKKHVW FGEAMTDGFQ FEYGSEGSSA QDVNIQLTFL RLMATEASQN
1360 1370 1380 1390 1400
ITYHCKNSIA YMDQQSGNLK KSLLLQGSNE IEIRAEGNSR FTYSVTEDGC
1410 1420 1430 1440
TSHTGAWGKT VIDYKTTKTS RLPIIDIAPM DVGAPNQEFG IEVGPVCFL
Length:1,449
Mass (Da):136,936
Last modified:April 12, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA0D9F6ABC5AEC74E
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_014059932.1, XM_014204457.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSAT00000014390; ENSSSAP00000013514; ENSSSAG00000006686

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100286406

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sasa:100286406

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_014059932.1, XM_014204457.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

Allergomei12212 Sal s 6
12213 Sal s 6.0101

Genome annotation databases

EnsembliENSSSAT00000014390; ENSSSAP00000013514; ENSSSAG00000006686
GeneIDi100286406
KEGGisasa:100286406

Phylogenomic databases

KOiK06236
OrthoDBi337699at2759

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR000885 Fib_collagen_C
IPR001007 VWF_dom
PfamiView protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 7 hits
PF00093 VWC, 1 hit
SMARTiView protein in SMART
SM00038 COLFI, 1 hit
SM00214 VWC, 1 hit
PROSITEiView protein in PROSITE
PS51461 NC1_FIB, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1S3S6G4_SALSA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1S3S6G4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: June 17, 2020
This is version 14 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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