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Entry version 11 (31 Jul 2019)
Sequence version 1 (12 Apr 2017)
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Protein

Histone-lysine N-methyltransferase

Gene

LOC106601577

Organism
Salmo salar (Atlantic salmon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotation, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC106601577Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmo salar (Atlantic salmon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8030 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000087266 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini105 – 219SETInterPro annotationAdd BLAST115

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni678 – 719DisorderedSequence analysisAdd BLAST42
Regioni809 – 847DisorderedSequence analysisAdd BLAST39
Regioni880 – 1038DisorderedSequence analysisAdd BLAST159
Regioni1053 – 1160DisorderedSequence analysisAdd BLAST108
Regioni1502 – 1533DisorderedSequence analysisAdd BLAST32
Regioni1571 – 1594DisorderedSequence analysisAdd BLAST24
Regioni1811 – 1835DisorderedSequence analysisAdd BLAST25
Regioni1961 – 2006DisorderedSequence analysisAdd BLAST46
Regioni2019 – 2058DisorderedSequence analysisAdd BLAST40
Regioni2074 – 2112DisorderedSequence analysisAdd BLAST39
Regioni2176 – 2227DisorderedSequence analysisAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1409 – 1429Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi682 – 701PolarSequence analysisAdd BLAST20
Compositional biasi702 – 719PolyampholyteSequence analysisAdd BLAST18
Compositional biasi820 – 834PolarSequence analysisAdd BLAST15
Compositional biasi899 – 921PolyampholyteSequence analysisAdd BLAST23
Compositional biasi923 – 943PolarSequence analysisAdd BLAST21
Compositional biasi984 – 998PolarSequence analysisAdd BLAST15
Compositional biasi1010 – 1038PolarSequence analysisAdd BLAST29
Compositional biasi1063 – 1089PolarSequence analysisAdd BLAST27
Compositional biasi1100 – 1159PolyampholyteSequence analysisAdd BLAST60
Compositional biasi2041 – 2058PolarSequence analysisAdd BLAST18
Compositional biasi2197 – 2220PolarSequence analysisAdd BLAST24

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K11429

Database of Orthologous Groups

More...
OrthoDBi
236983at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.1700, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041938 Hist-Lys_N-MTase_N
IPR025790 Hist-Lys_N-MTase_Suvar4-20
IPR039977 KMT5B/KMT5C/SET9
IPR001214 SET_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12977 PTHR12977, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00856 SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00317 SET, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51570 SAM_MT43_SUVAR420_2, 1 hit
PS50280 SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A1S3RAH3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGCSKMSVM ELCETDDLAT SLVLDPLLGF STHKMNVSPP PEVRRWGYLK
60 70 80 90 100
ETLLRFQRTH DLQATFEALT VGDWACDYFT GLGTHRLELL KQHVYRYLCA
110 120 130 140 150
FLLDSGVQIE SCDRYSSETN GAKITSTKHW FVGERMEVLL GCIAELSPAD
160 170 180 190 200
SAVLRAGVND FSVMYSTRKR CAQLWLGPAA FINHDCRPNC KFVPGDKNGG
210 220 230 240 250
CVKVVRPIAP GEEITCYYGD SFFGEDNEMC ECCTCERKGE GHFRHRERQP
260 270 280 290 300
GCDDSNDLSG QKYRLRDTDL RLNRGKAPCP PTFRPTFTFS NSAIPSRNSF
310 320 330 340 350
TQQMKRNALM MSRKTKRLKQ EGQRRISGMK QQRLIMPSLS EVVLRNLRVR
360 370 380 390 400
VRRHTFNFLL SCKDPTSKER ALLHQLEHVE TKDKWRKEQS ALCCTTKEND
410 420 430 440 450
KKEKSSNTCE LNLKPFTLHP SLSSQQNAGP AVCGQILGGK PLRVVEKVSV
460 470 480 490 500
QTRISSRTRS MIRNCHTRQS VSRAKKNNKI ISKRIELTKP ICRKSNSASP
510 520 530 540 550
QKHMDSCSGK DATHNVIGDI HGTNCITIEN NTSGNNNDVA YISNRTYTGG
560 570 580 590 600
GGPKGSKAQG ADQKPVDLKV EIKTIGESGT DGTLVASKPS GKRVEVCQSA
610 620 630 640 650
LDKAKKPGNH QKPISTPLVT TTPSTISLSS PSLDHVPVMS GLKQVTVSLI
660 670 680 690 700
RVSVPGSVAE ERACPGLEGK GIVRRESSVP VQAEQMARSA TQGGEADTRV
710 720 730 740 750
SRSQQKSMEE AGRELSDAEG KKGVREMYFK AKANKVDVGR GQIAVVKVDV
760 770 780 790 800
LHGEKGAGEK VIEIEAAGGG EQVSVAGNGH RGSVKDIDRG AKLISKSVQS
810 820 830 840 850
QVVGCDKRVL RGRNDAEEQS NGKAGGQNSK SCDSIIRKDG GKNEKVSEMV
860 870 880 890 900
KKGSSIAMDK KGVVIKQVRV LLSDILRKER DQKAGGSGSG NTGKKDLISS
910 920 930 940 950
NHKQMEDGRE ANNDGGKEVR EQIYDAQTNS LPHATTQSGI ISKRGKGRAS
960 970 980 990 1000
KMKLEGPGQD LHIHSPQSND DLIPAKDRLS KSPPPSSEYL QTHTQANIPL
1010 1020 1030 1040 1050
KKRMFRNSVE TDSEQSINSP VSEPSSKDLK PSTELRQNLT LCSGRETKAI
1060 1070 1080 1090 1100
KVLEDRGRGG LRSNSDPKST VSEFGVQSRT QTFKRTGKQN ATPRMLRPRV
1110 1120 1130 1140 1150
NQLEQDRPRR SAGKYKRGTR DSEVLENESD EDKHKVGHDE ISLDSKKEHV
1160 1170 1180 1190 1200
NEGENKPESH TELLNSLTSQ TCKEENGKGQ SLNFKIRFKR KRGKVWELDR
1210 1220 1230 1240 1250
PAGGEDLIIE AEKSIDSQQL EPYRAILDSV SILNLEMEKG AQADGKETHD
1260 1270 1280 1290 1300
VRFWKRRKVR RDRLGSLKDR GPILMNRQSE VVAVDSKEKE KEQGELSEVE
1310 1320 1330 1340 1350
ISEVLDEVIY GVKQLPGEKG HTTSSEGISV GVGGLQCDYQ VTPSPVRICE
1360 1370 1380 1390 1400
KEKDIPSLAE DGEQVKDTCI GVESSLVDSG ALHEHKVKDE DQPLPRIKLR
1410 1420 1430 1440 1450
RKIQGVWEVD SQELEQSEAE SEKEKKEMTC VKPKEECPSQ PPTCQKLNSA
1460 1470 1480 1490 1500
IKCNTLKDSS AVLLKKEPPP LTLSLSTLTL NSPQPVGSDV MAYAPETMND
1510 1520 1530 1540 1550
RAMPKITNRG GRGRGRGRKE RQKTETARKV ATGEMGTSCL SHNLLQIDNS
1560 1570 1580 1590 1600
LSRLSEGLCQ SQSLEKNIPS DYTASTSKIP SQSQSQSPPF SFPERMLSTE
1610 1620 1630 1640 1650
SSFANCCEDL LDFQCLNLEG FYHPQNILQT SPIDLCPMDP PSGPFSSPLS
1660 1670 1680 1690 1700
HSPSDAWNPE TPYLGPPSPG SIFNAEDQQF LNGLVCSKNE SLPLDCGVKD
1710 1720 1730 1740 1750
ASKDRGQLNA NFCFTSLSSA EGTFMDRFLM KNPGMKLSKE DSKTQALSSA
1760 1770 1780 1790 1800
AKTHYSQKES FMFNTNTPSI GSHSQNTPVN VLNQSTNGTK ASSAHSNFSK
1810 1820 1830 1840 1850
VQPQVKTPGP FHLMSSSNKS QSFSTSQPVP SSFKTGPQNY SVKSVHSPQV
1860 1870 1880 1890 1900
VSNKFGSQLN PNVGDAFRNT HDKSSSVIQS VLKFQGGKPS QNLNSAPSKV
1910 1920 1930 1940 1950
NIVAGNPKIA AKPHIAKSRY SDTDKVHQSN KCSGFSTGGH KGSVPSYSII
1960 1970 1980 1990 2000
SGKDPVRLNA SNYPIKSNLP NDKVHPDYFQ TSSKSTTTTL EKPPSDKPQY
2010 2020 2030 2040 2050
TETSFGSKNF STLPRPFFFP SQAPQSYGSP HGKHLNQDKP CAAVHSQNPH
2060 2070 2080 2090 2100
SSYATSASPD KLCYDSSDLT FSTSLSPSMS QHNSPQVAHS SPSGSQTPAN
2110 2120 2130 2140 2150
KQQPPSSSFS YSYGHQGPPY VVNFTGDHSV TMGLGDYPGS PPTNYTYRCL
2160 2170 2180 2190 2200
MEPSGTQGRL VLEPCGPQLS HSPSFSVGGF SGLKGQDDHC KRDTQQQCQP
2210 2220 2230 2240
IDHPPTSHHA PTSSHSLSTP VSDRKPKRLR LVVTDGLVDL DLQYTD
Length:2,246
Mass (Da):246,373
Last modified:April 12, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i987DC97F36F332AE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1S3RB49A0A1S3RB49_SALSA
Histone-lysine N-methyltransferase
LOC106601577
784Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_014049360.1, XM_014193885.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
106601577

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sasa:106601577

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_014049360.1, XM_014193885.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi106601577
KEGGisasa:106601577

Phylogenomic databases

KOiK11429
OrthoDBi236983at2759

Family and domain databases

Gene3Di1.10.10.1700, 1 hit
InterProiView protein in InterPro
IPR041938 Hist-Lys_N-MTase_N
IPR025790 Hist-Lys_N-MTase_Suvar4-20
IPR039977 KMT5B/KMT5C/SET9
IPR001214 SET_dom
PANTHERiPTHR12977 PTHR12977, 1 hit
PfamiView protein in Pfam
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM00317 SET, 1 hit
PROSITEiView protein in PROSITE
PS51570 SAM_MT43_SUVAR420_2, 1 hit
PS50280 SET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1S3RAH3_SALSA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1S3RAH3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: July 31, 2019
This is version 11 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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