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UniProtKB - A0A1S3Q8U7 (A0A1S3Q8U7_SALSA)

Entry version 21 (10 Feb 2021)
Sequence version 1 (12 Apr 2017)
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Protein
Submitted name:

transcriptional activator GLI3 isoform X1

Gene

gli3

Organism
Salmo salar (Atlantic salmon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation, RepressorARBA annotation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
transcriptional activator GLI3 isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gli3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmo salar (Atlantic salmon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8030 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Protacanthopterygii › Salmoniformes › Salmonidae › Salmoninae › Salmo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000087266 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini497 – 529C2H2-typeInterPro annotationAdd BLAST33
Domaini535 – 562C2H2-typeInterPro annotationAdd BLAST28
Domaini563 – 592C2H2-typeInterPro annotationAdd BLAST30
Domaini593 – 623C2H2-typeInterPro annotationAdd BLAST31
Domaini624 – 654C2H2-typeInterPro annotationAdd BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 94DisorderedSequence analysisAdd BLAST94
Regioni390 – 453DisorderedSequence analysisAdd BLAST64
Regioni637 – 689DisorderedSequence analysisAdd BLAST53
Regioni712 – 738DisorderedSequence analysisAdd BLAST27
Regioni823 – 868DisorderedSequence analysisAdd BLAST46
Regioni882 – 961DisorderedSequence analysisAdd BLAST80
Regioni1071 – 1093DisorderedSequence analysisAdd BLAST23
Regioni1209 – 1295DisorderedSequence analysisAdd BLAST87
Regioni1361 – 1398DisorderedSequence analysisAdd BLAST38
Regioni1423 – 1444DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi33 – 48PolarSequence analysisAdd BLAST16
Compositional biasi420 – 443PolarSequence analysisAdd BLAST24
Compositional biasi637 – 661PolyampholyteSequence analysisAdd BLAST25
Compositional biasi889 – 926PolarSequence analysisAdd BLAST38
Compositional biasi940 – 958PolarSequence analysisAdd BLAST19
Compositional biasi1231 – 1248PolarSequence analysisAdd BLAST18
Compositional biasi1261 – 1291PolarSequence analysisAdd BLAST31
Compositional biasi1379 – 1398PolarSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GLI C2H2-type zinc-finger protein family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		56870at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043359, GLI-like
IPR032851, GLI3
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

The PANTHER Classification System

More...PANTHERi		PTHR45718, PTHR45718, 2 hits
PTHR45718:SF5, PTHR45718:SF5, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 4 hits
PS50157, ZINC_FINGER_C2H2_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A1S3Q8U7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METQSQASSA AEKKKRVETI VATKGSSARA DISEKAVASS TTSNEDESLG 
        60         70         80         90        100
TPYHHHHHHR ERRNAISTQA PTPGPPGSKL GEEPSTSTEE RPPLVKKELH 
       110        120        130        140        150
SSLPHLVDHG LPYRGTLFAM DPRNGYLDSH YAPPQFFPAF HPPVPIDDRH 
       160        170        180        190        200
AQGRYIYEPS PVPPLHVLCR PPSLAGSPAF SDISLIRISP HRNPSVGAES 
       210        220        230        240        250
PFNPPHPYIN PYMDYIRSLH SSPSLSMISA ARGLSPADVP HTGLTTAEYY 
       260        270        280        290        300
HQMAILAGHR SPYTDLLPSV ASTAGATSSA LHMEYLQAVE SSRFPSPRLT 
       310        320        330        340        350
ARPSRKRALP ISPLSEHSFD LQTMIRSSPN SLVTILNNSR SSSSTNGSYG 
       360        370        380        390        400
HLSAGAISPA LSFAYPPTPV ALQMHQQLLG RQPGIVGSAF GHSPPLIHPS 
       410        420        430        440        450
PAFATQRPVP GIPPPGLTPS ERSVISNDSS QTKPTSESAV SSTGDPMHHK 
       460        470        480        490        500
RSKIKPDEEL LSPGAVCCQD HPDGMTLVKE EGDKDDSKQE PEVVYETNCH 
       510        520        530        540        550
WESCHREFDT QEQLVHHINN DHIHGEKKEF VCHWDECSRE QKPFKAQYML 
       560        570        580        590        600
VVHMRRHTGE KPHRCTFEGC PKAYSRLENL KTHLRSHTGE KPYVCEHEGC 
       610        620        630        640        650
NKAFSNASDR AKHQNRTHSN EKPYVCKIPG CTKRYTDPSS LRKHVKTVHG 
       660        670        680        690        700
PEAHVTKKQR SDGFPRPPPQ SREGGNGQGR SPGQLGGYAD QREYNHATSK 
       710        720        730        740        750
QDECLQVKSI KTEKPMTSQP SPGGQSTCSS DQSPISAYPS HGVQLAVRGG 
       760        770        780        790        800
VVGLGEGPGE EDEELEEEEE GLEVLEGGRD APIMDSTVST ATAATLALQA 
       810        820        830        840        850
RRNVGRPMRW MEHMKMERLK QVNGGGGALM PRVGPLSPTP PPKGPAVLGS 
       860        870        880        890        900
CLGRLSQPQP PPRPELGSTE LTVLSLLRGI EHGDRRDSSG SATSSAYLSS 
       910        920        930        940        950
SRRSSGISPC FSSRRSSQAS QSEAANTPGH HRRHHNLSST DSYDPISTDA 
       960        970        980        990       1000
SRRSSEASQC GGGGGVFVGG GWAGVGGGSK GMLNLTPAQH YHLKAKYAAA 
      1010       1020       1030       1040       1050
TGGPPPTPLP NMERMSLKTR MAMMCDGQDG CGGNHALPPL VRPRRCSDGS 
      1060       1070       1080       1090       1100
TTNGYGGHSG YRDYRRRGFY PGEGPGNGLD RRASDPVRTQ PQQTHPEFLG 
      1110       1120       1130       1140       1150
LPQVQRFSSL NNIHPLPPLS GLQHPTAEGR SFSLQNYTRS EGNLQRGGLL 
      1160       1170       1180       1190       1200
SSPCPPSIME HAALEALAME EEGALLLGDE DMLPDDLVQY LHSQDLRSQD 
      1210       1220       1230       1240       1250
QADSYNNHLE NHVAGDNSHL PGGELQDQGP GLNQCIHSLQ QHHQQQQGLE 
      1260       1270       1280       1290       1300
RDGPSKDGMP IQWNEVSSGS AERSPQRQPQ VQAQQRCGRW AATEQHQGLG 
      1310       1320       1330       1340       1350
AGSSFGRFGN MVVQQQQQTV TTRDFQNRCA QPGQPQPICR VNGGVKLEAT 
      1360       1370       1380       1390       1400
THSCMEMRGN GHNPTHTFGR PDFSQISVGP LPQGYSQQQY QTQNHGTSRQ 
      1410       1420       1430       1440       1450
IGDNLLLSRA SVDSLTSLSQ APALHHHPQA PAPRLQQANS SYRHPARPQQ 
      1460       1470       1480       1490       1500
YLNAQQSTTN GSHVNLTQQN LTQQQQSLRN QVSHCSLAHQ VSGLKLEAPD 
      1510       1520       1530       1540       1550
QGYLDQSFSD QAVCFDPLET KTSSFSPMEE QCLLETMNEQ VGLGGDSSVT 
      1560       1570       1580       1590       1600
ASHLSPVADQ VTSTVDSRAG GSVNVLDNVL PLDFGAMIED VGVGYDQGSL 
      1610       1620       1630       1640       1650
VSGVISPSIF QGVSRNSSRL TTPRVSATFH STAGMMPSNL SNMAIGDMSS 
      1660 
LLTTLAEESK FLAIMQ
Length:1,666
Mass (Da):180,539
Last modified:April 12, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8769163645596F7C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1S3Q8U9A0A1S3Q8U9_SALSA
transcriptional activator GLI3 isof...
gli3
1,579Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1S3Q8X6A0A1S3Q8X6_SALSA
transcriptional activator GLI3 isof...
gli3
1,663Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1S3Q927A0A1S3Q927_SALSA
transcriptional activator GLI3 isof...
gli3
1,662Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_014036400.1, XM_014180925.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSSSAT00000123302; ENSSSAP00000089263; ENSSSAG00000070213

Database of genes from NCBI RefSeq genomes

More...GeneIDi		106590190

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sasa:106590190

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_014036400.1, XM_014180925.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSSSAT00000123302; ENSSSAP00000089263; ENSSSAG00000070213
GeneIDi106590190
KEGGisasa:106590190

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2737

Phylogenomic databases

OrthoDBi56870at2759

Family and domain databases

InterProiView protein in InterPro
IPR043359, GLI-like
IPR032851, GLI3
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PANTHERiPTHR45718, PTHR45718, 2 hits
PTHR45718:SF5, PTHR45718:SF5, 2 hits
PfamiView protein in Pfam
PF00096, zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 5 hits
SUPFAMiSSF57667, SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 4 hits
PS50157, ZINC_FINGER_C2H2_2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1S3Q8U7_SALSA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1S3Q8U7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: February 10, 2021
This is version 21 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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