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Entry version 21 (10 Feb 2021)
Sequence version 1 (12 Apr 2017)
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Protein
Submitted name:

low-density lipoprotein receptor-related protein 2-like isoform X1

Gene

LOC106586206

Organism
Salmo salar (Atlantic salmon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImportedARBA annotation
Biological processEndocytosisARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
low-density lipoprotein receptor-related protein 2-like isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC106586206Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmo salar (Atlantic salmon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8030 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000087266 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4373 – 4396HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 37Sequence analysisAdd BLAST37
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501030651538 – 4603Sequence analysisAdd BLAST4566

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi41 ↔ 53PROSITE-ProRule annotation
Disulfide bondi48 ↔ 66PROSITE-ProRule annotation
Disulfide bondi60 ↔ 75PROSITE-ProRule annotation
Disulfide bondi85 ↔ 103PROSITE-ProRule annotation
Disulfide bondi97 ↔ 112PROSITE-ProRule annotation
Disulfide bondi116 ↔ 128PROSITE-ProRule annotation
Disulfide bondi123 ↔ 141PROSITE-ProRule annotation
Disulfide bondi135 ↔ 150PROSITE-ProRule annotation
Disulfide bondi155 ↔ 167PROSITE-ProRule annotation
Disulfide bondi162 ↔ 180PROSITE-ProRule annotation
Disulfide bondi174 ↔ 189PROSITE-ProRule annotation
Disulfide bondi282 ↔ 292PROSITE-ProRule annotation
Disulfide bondi956 ↔ 968PROSITE-ProRule annotation
Disulfide bondi963 ↔ 981PROSITE-ProRule annotation
Disulfide bondi975 ↔ 990PROSITE-ProRule annotation
Disulfide bondi998 ↔ 1010PROSITE-ProRule annotation
Disulfide bondi1005 ↔ 1023PROSITE-ProRule annotation
Disulfide bondi1017 ↔ 1032PROSITE-ProRule annotation
Disulfide bondi1040 ↔ 1052PROSITE-ProRule annotation
Disulfide bondi1047 ↔ 1065PROSITE-ProRule annotation
Disulfide bondi1059 ↔ 1074PROSITE-ProRule annotation
Disulfide bondi1080 ↔ 1092PROSITE-ProRule annotation
Disulfide bondi1087 ↔ 1105PROSITE-ProRule annotation
Disulfide bondi1099 ↔ 1114PROSITE-ProRule annotation
Disulfide bondi1138 ↔ 1153PROSITE-ProRule annotation
Disulfide bondi1203 ↔ 1215PROSITE-ProRule annotation
Disulfide bondi1210 ↔ 1228PROSITE-ProRule annotation
Disulfide bondi1222 ↔ 1237PROSITE-ProRule annotation
Disulfide bondi1331 ↔ 1341PROSITE-ProRule annotation
Disulfide bondi2636 ↔ 2648PROSITE-ProRule annotation
Disulfide bondi2643 ↔ 2661PROSITE-ProRule annotation
Disulfide bondi2686 ↔ 2698PROSITE-ProRule annotation
Disulfide bondi2693 ↔ 2711PROSITE-ProRule annotation
Disulfide bondi2705 ↔ 2720PROSITE-ProRule annotation
Disulfide bondi2733 ↔ 2751PROSITE-ProRule annotation
Disulfide bondi2809 ↔ 2821PROSITE-ProRule annotation
Disulfide bondi2816 ↔ 2834PROSITE-ProRule annotation
Disulfide bondi2851 ↔ 2863PROSITE-ProRule annotation
Disulfide bondi2858 ↔ 2876PROSITE-ProRule annotation
Disulfide bondi2938 ↔ 2950PROSITE-ProRule annotation
Disulfide bondi2945 ↔ 2963PROSITE-ProRule annotation
Disulfide bondi2957 ↔ 2972PROSITE-ProRule annotation
Disulfide bondi2977 ↔ 2989PROSITE-ProRule annotation
Disulfide bondi2984 ↔ 3002PROSITE-ProRule annotation
Disulfide bondi3020 ↔ 3032PROSITE-ProRule annotation
Disulfide bondi3027 ↔ 3045PROSITE-ProRule annotation
Disulfide bondi3039 ↔ 3054PROSITE-ProRule annotation
Disulfide bondi3497 ↔ 3509PROSITE-ProRule annotation
Disulfide bondi3504 ↔ 3522PROSITE-ProRule annotation
Disulfide bondi3538 ↔ 3550PROSITE-ProRule annotation
Disulfide bondi3545 ↔ 3563PROSITE-ProRule annotation
Disulfide bondi3579 ↔ 3591PROSITE-ProRule annotation
Disulfide bondi3586 ↔ 3604PROSITE-ProRule annotation
Disulfide bondi3643 ↔ 3658PROSITE-ProRule annotation
Disulfide bondi3671 ↔ 3689PROSITE-ProRule annotation
Disulfide bondi3683 ↔ 3698PROSITE-ProRule annotation
Disulfide bondi3703 ↔ 3715PROSITE-ProRule annotation
Disulfide bondi3710 ↔ 3728PROSITE-ProRule annotation
Disulfide bondi3722 ↔ 3737PROSITE-ProRule annotation
Disulfide bondi3742 ↔ 3754PROSITE-ProRule annotation
Disulfide bondi3749 ↔ 3767PROSITE-ProRule annotation
Disulfide bondi3761 ↔ 3776PROSITE-ProRule annotation
Disulfide bondi3786 ↔ 3798PROSITE-ProRule annotation
Disulfide bondi3793 ↔ 3811PROSITE-ProRule annotation
Disulfide bondi3835 ↔ 3853PROSITE-ProRule annotation
Disulfide bondi3872 ↔ 3884PROSITE-ProRule annotation
Disulfide bondi3879 ↔ 3897PROSITE-ProRule annotation
Disulfide bondi3891 ↔ 3906PROSITE-ProRule annotation
Disulfide bondi4346 ↔ 4355PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation, LipoproteinImported

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini278 – 316EGF-likeInterPro annotationAdd BLAST39
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati366 – 408LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati409 – 451LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati452 – 498LDL-receptor class BPROSITE-ProRule annotationAdd BLAST47
Repeati499 – 543LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati683 – 725LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati726 – 767LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Repeati768 – 811LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati812 – 855LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Domaini1327 – 1366EGF-likeInterPro annotationAdd BLAST40
Repeati1415 – 1457LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1458 – 1500LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1503 – 1546LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati1547 – 1591LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati1592 – 1632LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Repeati1727 – 1769LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1770 – 1819LDL-receptor class BPROSITE-ProRule annotationAdd BLAST50
Repeati1820 – 1867LDL-receptor class BPROSITE-ProRule annotationAdd BLAST48
Repeati1868 – 1909LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Repeati1910 – 1950LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Repeati2044 – 2093LDL-receptor class BPROSITE-ProRule annotationAdd BLAST50
Repeati2094 – 2138LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati2139 – 2182LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati2183 – 2226LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati2227 – 2269LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati2368 – 2414LDL-receptor class BPROSITE-ProRule annotationAdd BLAST47
Repeati2415 – 2455LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Repeati2456 – 2499LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati2500 – 2541LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Repeati2542 – 2583LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Domaini3055 – 3096EGF-likeInterPro annotationAdd BLAST42
Domaini3097 – 3137EGF-likeInterPro annotationAdd BLAST41
Repeati3184 – 3225LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Repeati3226 – 3268LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati3277 – 3320LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati3321 – 3363LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati3364 – 3404LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Domaini3910 – 3945EGF-likeInterPro annotationAdd BLAST36
Repeati4043 – 4097LDL-receptor class BPROSITE-ProRule annotationAdd BLAST55
Repeati4098 – 4140LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati4141 – 4184LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati4186 – 4228LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Domaini4322 – 4356EGF-likeInterPro annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni4551 – 4603DisorderedSequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4551 – 4569PolarSequence analysisAdd BLAST19
Compositional biasi4577 – 4592PolarSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LDLR family.ARBA annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
1606at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112, LDLa, 33 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 8 hits
4.10.400.10, 33 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR026823, cEGF
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12662, cEGF, 1 hit
PF07645, EGF_CA, 3 hits
PF00057, Ldl_recept_a, 32 hits
PF00058, Ldl_recept_b, 16 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261, LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 22 hits
SM00179, EGF_CA, 9 hits
SM00192, LDLa, 34 hits
SM00135, LY, 38 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184, SSF57184, 2 hits
SSF57424, SSF57424, 34 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 3 hits
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 5 hits
PS50026, EGF_3, 6 hits
PS01187, EGF_CA, 3 hits
PS01209, LDLRA_1, 16 hits
PS50068, LDLRA_2, 34 hits
PS51120, LDLRB, 37 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A1S3PM22-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSWTEQPGP SIRMWRAVLA KLLIILILCT FRCHSQAGRR CSSEQFSCTN
60 70 80 90 100
GACIPGEYRC DRLTDCSDGA DETDCHYPEC TELRCANGAC YNQTQRCDQV
110 120 130 140 150
VDCRDGSDES NCTQHCSSGL FQCGNGECVP QRYVCDHDDD CGDRSDEQNC
160 170 180 190 200
TYPACRGSYF TCPSGRCIHQ VWLCDGEDDC EDNADEKGCD AIPRECYPGE
210 220 230 240 250
WPCPSSGLCI PMDQLCDGTA QCPDGEDETS TTAGRNCSIW RCASLSCEHR
260 270 280 290 300
CHASPEGGTC SCPPGYIVNN NNSRSCIDFD DCTMWGVCDQ LCEDRMGTHR
310 320 330 340 350
CSCREGYFLE QHRYCSANIS TGVPSLIFSN GRDLLIGDIH GHSSRTLVHS
360 370 380 390 400
RNRGVVVGVD FHFHLKRVFW TDTIQNKVFS VDMDGSNMQV VLNVSVDYPE
410 420 430 440 450
NLAVDWVNNK LYMVESSVNR IDMVDFDGNN RVTLIAENLG NPRGLALDPT
460 470 480 490 500
VGFLFFSDWD SVNGEPGLER AYMDGTNRYG IIRTKLGWPA GITLDIDAKR
510 520 530 540 550
VYWVDSRYDY IETTTYDGLH RKTVVHGGAV IPHPFGISMF EHIVYFTDWT
560 570 580 590 600
KMAVMKANKF SDTNPQVVYT TSQTPHGVQV VHQLRQPYVS NPCGANRGGC
610 620 630 640 650
EQICILSHRS DNQGLGYRCR CCMGYDLHAD GKRCVAVRQF LLFSSQLAVR
660 670 680 690 700
GIPFNLSSQE DVILPVTGTP SYFVGVDFSA EDNAIFFSDT AKDIIYKQKV
710 720 730 740 750
DGTGREVLAA NRVDGVEDLA YDWISKNLYW TDPRYRSISV MKLADQSRRA
760 770 780 790 800
IIRNLNSPRS IVVHPVIGYI FWTDWYRPAK IMRAWCDGSH ALSIVNTTLG
810 820 830 840 850
WPNGLAIDWS SMRLYWVDAF FDKIEHSTFD GRNRLSLERI TQISHPFGLT
860 870 880 890 900
IFGGYAYFTD WRLGGIVRVR KTDGGEMVII RRGISHIMHV KSFNSNSQTG
910 920 930 940 950
SNFCSRNTNP NGDCSHFCFP APDSQRVCGC PYGLKLAPNQ QTCVEDPSNE
960 970 980 990 1000
PPTLQCGANS FSCTNGKCVP QNYRCDGVDD CHDNSDEANC GRAHNTTCSP
1010 1020 1030 1040 1050
RAFTCANQQC VPSGWHCDGH NDCFDGSDER DCPTQNPGTC PANQFTCANH
1060 1070 1080 1090 1100
RCIPHTWVCD TDNDCGDSSD EANCNLSGSC HPEQFQCPDH RCIGPSYVCD
1110 1120 1130 1140 1150
GDRDCMDGAD EQGCIYNCTL YEFKCSNGHQ CINSYYRCDG VFDCSDRSDE
1160 1170 1180 1190 1200
SGCPTRPPGM CHHESEFQCQ SDGSCIPSTW ECDGHPDCED GSDEHHVCPP
1210 1220 1230 1240 1250
RTCPTTLFRC DNGNCVYRGW LCDGDNDCRD MSDERNCPTP PFRCPSWQWQ
1260 1270 1280 1290 1300
CPGHSVCVNI SRVCDNNPDC PNGADESPLC NEPLPDQESC TDNNAGCTHG
1310 1320 1330 1340 1350
CIQGPFGAQC TCPLGYQLSN DWKTCDDLNE CNPPGLCSQH CFNERGSFRC
1360 1370 1380 1390 1400
HCSDGYTLEA DQHTCKVSGS REAFLLVASR NQIVSDDITT QPNVVRSLVR
1410 1420 1430 1440 1450
DGRNIVALDF DSVTDRVYWS DTSQDRIWSA HKNGSDRAVV FDSGVTVTES
1460 1470 1480 1490 1500
LAVDWVGRNL YWTDYVLETI EVSKLDGTHR TVLVSENVTN PRALVLDPRD
1510 1520 1530 1540 1550
SAHLMFWTDW GRNPRIEKAS MDGKMRTTII SNKLYWPNGL TIDYPNNLLY
1560 1570 1580 1590 1600
FADAYLDFID YCDYNGNNRK QVLASDLVLQ HPHAITIFED FVYWTDRYIN
1610 1620 1630 1640 1650
RVIRAHKWHG ENQTVMLYNL PQPMGLVAVH PARQPAGENH CLRRLCTHIC
1660 1670 1680 1690 1700
LLSAIGPSYY SCACPSGWTL TADNFTCARV EDPFLVVVRD SVIYGMSLNP
1710 1720 1730 1740 1750
DDKSNDAMVP VAGLQNGYDV DFDDIERTIY WVEHPGEIHR VKSDGTNRTE
1760 1770 1780 1790 1800
FAPAAILGSP VGLALDWMAE NLYYTNPATQ SIEVLRLRGE VQYRKTLITN
1810 1820 1830 1840 1850
NGSPTGAGSP VGIAVDPARG KLYWTDQGTE SGIPAKVAAA DMDGSNPVIL
1860 1870 1880 1890 1900
FTNNLDHVEF ITVDIQENKL YWAVTGTGMI ERGDPDGTNR ITIVTGLSHP
1910 1920 1930 1940 1950
WGVAVHERFL YFTDRDFEVI ERVDKATGAN KVVLRDNVSG LRVLKVHYRE
1960 1970 1980 1990 2000
ISAGTSNGCS NNIGACEHLC LPRPRGLYTC ACATGFKLSV NNRTCAPYQS
2010 2020 2030 2040 2050
YVVISMLSAL KGFSLEGADH SEAMVPVAGR GRNALHVDIH MPSGFLYWCD
2060 2070 2080 2090 2100
FSSTVTSQNG IRRIKPDGAG FRSVVTSGIG RNGIRGIAVD WAAGNLYFTN
2110 2120 2130 2140 2150
AFLTETYVEV LRLNTTFRRV LLKTQVDMPR HIVVDPKNRY LFWADYGQNP
2160 2170 2180 2190 2200
KIERALLDGT NRTVLVSSGI ITPRGLALDF QTGYVYWVDD SLDMIARVNP
2210 2220 2230 2240 2250
QGGETEIVRY GSRYPTPYGI TVFETSIIWV DRNLKKVFQA SKEPGSTEQP
2260 2270 2280 2290 2300
TVIRDNINML RDVTIYDQRI QPSSAQQLNN NPCLQTNGGC AHFCFALPGS
2310 2320 2330 2340 2350
QTKKCGCAFG NLGADNAGCV VSRDDYLIYT TESTVRSLRL DPDDHALPFP
2360 2370 2380 2390 2400
VVNVPRTSVA LDFDRTDNRI YFTQSSGAGS SKISYISLSS PTSPPVAVAS
2410 2420 2430 2440 2450
DLGAPDGIAY DWINKRIYYS DYINQTISSM ALDGTQRSII ARVLRPRAIM
2460 2470 2480 2490 2500
LDPCRGYMYW TDWGTNAKIE RATLGGNFRT EIVNSSLVWP NGLTLDYEEQ
2510 2520 2530 2540 2550
RLYWADASLQ KIERCSLTGA NREIIVSTAI YPFAMTMYGQ YIYWTDWNTR
2560 2570 2580 2590 2600
SIYRANKHDG SDQRVMTQNL PSRPMDVHVL ASNKQQQCNS PCQQFNGGCS
2610 2620 2630 2640 2650
HICTPGPQGA ECQCPSEGRW YLADNKHCIP DNGTRCQAGQ FTCMNGRCIR
2660 2670 2680 2690 2700
AQWKCDNDND CVDGSDELER VCGSKNDFQP FAFHTCEPTV FTCGNGRCVP
2710 2720 2730 2740 2750
YHYRCDHYND CGDNSDEVGC LFRLCDPNTE FPCNNGRCIA KDYVCNGINN
2760 2770 2780 2790 2800
CFDNGTSDEQ NCPERTCPPE HTKCASNNIC IPRSYLCDGD NDCGDMSDES
2810 2820 2830 2840 2850
PVHCATSTCA QNEFHCSSGR CIPAHWYCDG GTDCADGSDE PSSCITLVRT
2860 2870 2880 2890 2900
CNTDQFRCDG GRCITSSWVC DGDNDCGDMS DEDQRHNCAN RTCSVLEFTC
2910 2920 2930 2940 2950
VNNLGPQRKC ISRDWVCDGD ADCADALDEH QNCTRRSCGV NEFTCSNGLC
2960 2970 2980 2990 3000
IRSSYRCDRR NDCGDSSDEQ GCTYQPCQQH QFTCQNGRCV SLAFICDGDN
3010 3020 3030 3040 3050
DCGDESDELE HMCRTPPPTC PPGQFRCDNG HCVPLFNVCD RTDDCSDNSD
3060 3070 3080 3090 3100
EKGCGINECT NPSMHHCDHN CTDTPTSFIC TCRPGYRLMS DNKTCDDVNE
3110 3120 3130 3140 3150
CAETPSVCSQ VCENTVGSYM CKCAPGFLRE PDGRSCRQNS HITPYLIFSN
3160 3170 3180 3190 3200
RYYLRNLSTD GEAYSLILQG LTSVVAMDFD RVDKRFYWID VGRRVIERMF
3210 3220 3230 3240 3250
YNGSNREVVV NGVVHGEGLA VDWVGRKLYW LDSFLDCLKV SELDGRFAKK
3260 3270 3280 3290 3300
LAEHCVDANN TYCFENPRAL VLHPKYGYVY WTDWGEKAFI GRVGMDGTNK
3310 3320 3330 3340 3350
TAIITTKIEW PNGVTIDYSN DKLYWSDAHL NYIEFSDLEG HHRHTVYDGT
3360 3370 3380 3390 3400
LPHPFALTVF EETVYWTDWN THTVEKGNKY DGSGRQSLVN TTHRPFDIHV
3410 3420 3430 3440 3450
CHPFRQPIVT NPCADNNGGC SHLCLIRDGG RGHTCECPDH FLNVQLGGVA
3460 3470 3480 3490 3500
RCLPMCTSTQ YRCADNERCI PIWWKCDGQR DCRDGSDEPS TCPSRHCRLG
3510 3520 3530 3540 3550
QFQCNDGNCT SPHFLCNSNQ DCHDGSDEDP VLCATHQCET HQWQCANKRC
3560 3570 3580 3590 3600
IPEAWQCDGD DDCGDGSDEE PAHCSSRTCR PGQFKCRNGR CIPQNWKCDV
3610 3620 3630 3640 3650
DDDCGDNSDE PLEECMGPSY RCDNHTQFVC RTNYRCVPQW SVCNGHNDCR
3660 3670 3680 3690 3700
DNSDEQHCEE VTCNPLGDFR CDNHQCVPLR WRCDGDNDCG DGSDERACSP
3710 3720 3730 3740 3750
RVCSESEFRC DNLHCIPGRW VCDHDNDCED NSDERDCELR TCHPGYFQCG
3760 3770 3780 3790 3800
SGHCIADRFK CDGNADCLDY TDETSCPTRY PNGTYCPLFL FECRNHVCVQ
3810 3820 3830 3840 3850
PYWKCDGDND CGDHSDEELH LCLDIPCDPP FRFRCDNNRC IYSHELCNSV
3860 3870 3880 3890 3900
DDCGDGTDEK EEHCQTPTHG PCSADQFKCS NGQCIPLQYA CDDYDDCGDH
3910 3920 3930 3940 3950
SDELGCNVGS GRSCSENICE HNCTDLTDGG FLCSCRPGYK PSQTDRNTCE
3960 3970 3980 3990 4000
DVNECEVYGT CPQECQNSKG SYECFCAQGF RSVSEQHGIE CAAEGNPPVL
4010 4020 4030 4040 4050
LLPDNVRIRR FNLSSEQYSD YVDNAEHIQA LDYQWDPEGI GLSIVYWTVL
4060 4070 4080 4090 4100
GRGSQFGSIK RAYMTTFNDN GNNPVKELDL NLRYVANPDG IAVDWVGGHI
4110 4120 4130 4140 4150
YWTDAGTNRI EVAKLDGRYR KWLIHNDLDQ PAAIVLNPGL GIMYWTDWGR
4160 4170 4180 4190 4200
RPRIESAWMD GQHRQVLLDE DLGWPTGLTL DYLNGDRIYW CDSKENIIES
4210 4220 4230 4240 4250
MKPDGTERKI IMSGDIGNPY SLDVFEGHVY WTTKERGEVW KADKFGKEEK
4260 4270 4280 4290 4300
VKVLTINPWL TQVRIYQEHR YNRSVPNPCK DVCSHLCLIR PGGYTCTCPQ
4310 4320 4330 4340 4350
GSSLVGFNPN ECDAAIEVPV LMPLACRCMN GGTCYTDEGG LPKCKCQYGY
4360 4370 4380 4390 4400
AGAYCEMGKS RDAPEGAGTV KTVAALLAVI IFIITGALAV GVFLNYKRTG
4410 4420 4430 4440 4450
SLMPSMPNLP SLSSLVKSGD TGNGVTFRSG DNVTMDLGPP PIGVSFIDRA
4460 4470 4480 4490 4500
MQLDGNSAVE AGRPITFENH LYAHGATGSS SDPAVIHATQ VTVTVSGEQI
4510 4520 4530 4540 4550
EKNHKEQIVS TVDSSTARAK PVQESMWSAF RRKLKPSLTF ENPIYSEMQN
4560 4570 4580 4590 4600
EKAVGSNEES SSTDPSPFAP TTKRLKRDYP STYSPTEDTF QDTANLVKED

NDV
Length:4,603
Mass (Da):514,102
Last modified:April 12, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i286F6F8DF6A1F9DA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1S3PLY6A0A1S3PLY6_SALSA
low-density lipoprotein receptor-re...
LOC106586206
4,589Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1S3PN25A0A1S3PN25_SALSA
low-density lipoprotein receptor-re...
LOC106586206
4,599Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_014028697.1, XM_014173222.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
106586206

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sasa:106586206

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_014028697.1, XM_014173222.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi106586206
KEGGisasa:106586206

Phylogenomic databases

OrthoDBi1606at2759

Family and domain databases

CDDicd00112, LDLa, 33 hits
Gene3Di2.120.10.30, 8 hits
4.10.400.10, 33 hits
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR026823, cEGF
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt
PfamiView protein in Pfam
PF12662, cEGF, 1 hit
PF07645, EGF_CA, 3 hits
PF00057, Ldl_recept_a, 32 hits
PF00058, Ldl_recept_b, 16 hits
PRINTSiPR00261, LDLRECEPTOR
SMARTiView protein in SMART
SM00181, EGF, 22 hits
SM00179, EGF_CA, 9 hits
SM00192, LDLa, 34 hits
SM00135, LY, 38 hits
SUPFAMiSSF57184, SSF57184, 2 hits
SSF57424, SSF57424, 34 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 3 hits
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 5 hits
PS50026, EGF_3, 6 hits
PS01187, EGF_CA, 3 hits
PS01209, LDLRA_1, 16 hits
PS50068, LDLRA_2, 34 hits
PS51120, LDLRB, 37 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1S3PM22_SALSA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1S3PM22
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: February 10, 2021
This is version 21 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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