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Entry version 13 (10 Feb 2021)
Sequence version 1 (12 Apr 2017)
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Protein
Submitted name:

protein patched homolog 1 isoform X1

Gene

ptch1

Organism
Salmo salar (Atlantic salmon)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
protein patched homolog 1 isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ptch1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmo salar (Atlantic salmon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8030 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000087266 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei428 – 447HelicalSequence analysisAdd BLAST20
Transmembranei459 – 484HelicalSequence analysisAdd BLAST26
Transmembranei490 – 512HelicalSequence analysisAdd BLAST23
Transmembranei533 – 556HelicalSequence analysisAdd BLAST24
Transmembranei562 – 585HelicalSequence analysisAdd BLAST24
Transmembranei816 – 833HelicalSequence analysisAdd BLAST18
Transmembranei1092 – 1113HelicalSequence analysisAdd BLAST22
Transmembranei1119 – 1141HelicalSequence analysisAdd BLAST23
Transmembranei1148 – 1174HelicalSequence analysisAdd BLAST27
Transmembranei1186 – 1206HelicalSequence analysisAdd BLAST21
Transmembranei1218 – 1243HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini427 – 587SSDInterPro annotationAdd BLAST161

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 27DisorderedSequence analysisAdd BLAST27
Regioni623 – 650DisorderedSequence analysisAdd BLAST28
Regioni673 – 765DisorderedSequence analysisAdd BLAST93
Regioni1254 – 1454DisorderedSequence analysisAdd BLAST201
Regioni1470 – 1506DisorderedSequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi673 – 737PolarSequence analysisAdd BLAST65
Compositional biasi1276 – 1313PolarSequence analysisAdd BLAST38
Compositional biasi1358 – 1373PolarSequence analysisAdd BLAST16
Compositional biasi1470 – 1489PolarSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the patched family.ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
1190129at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003392, Ptc/Disp
IPR000731, SSD
IPR004766, TM_rcpt_patched

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02460, Patched, 1 hit
PF12349, Sterol-sensing, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00918, 2A060602, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50156, SSD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A1S3PFX8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASAANASSE QENRDPDRPR ITRRNRGNYR TTAPDLEYLQ RPSYCDAAFA
60 70 80 90 100
LEQISEGKAT GRKAPLWLRA KFQRLLFKLG CYIQKNCGKF LVVGLLIFGA
110 120 130 140 150
FAVGLRAANL ETDVEKLWVE VGGRVNQELK YTRQKMGEEA MFSPQLMIQT
160 170 180 190 200
PRQEGANVLT VEALQQHLDS AIRASRVHVY LFNRQWKLEH LCYKSGELVT
210 220 230 240 250
EAHFMDQIIE KLHPCLIITP LDCFWEGAKL QSGMVYLPGK PPLQWTNFDP
260 270 280 290 300
KEFLTELRTL KFQVDSWEEM LEKADVGHGY MDRPCLNPQD PDCPLTAPNK
310 320 330 340 350
NTTKPFDVAR VLTGGCHGLS RKYMHWQEEL IVGGTTKNGT GPLLSAQALQ
360 370 380 390 400
TMFQLMTPKQ MFEHLKGYEE VSHINWNQDK AAAILEAWQR KYSEAVQQSV
410 420 430 440 450
AANSSQKVLS FTTTTLEDIL KSFSDVSVIR VASGYLLMLA YACLTMLRWD
460 470 480 490 500
CAKSQGAVGL AGVLLVALSV AAGLGLCSLL GISFNAATTQ VLPFLALGVG
510 520 530 540 550
VDDVFLLAHA FSETGQNKRI PFEDRTGECL KRTGASVALT SISNVTAFFM
560 570 580 590 600
AALIPIPALR AFSLQAAVVV VFNFAMVLLI FPAILSMDLY RREDRRFDIF
610 620 630 640 650
CCFYSPCANR VIQIEPQAYL DGADGSHYSP PPTSFRTPPP SYSSHGFSQQ
660 670 680 690 700
TQITMQSTVQ LRTEYDPRTQ AFYTTAEPRS QISVQPFTPA ATGPASNPNA
710 720 730 740 750
SHGVHGNNNH HSNHHSRSGS SSSHGNLNNN NGSRGSGSVP FPPPPASSGV
760 770 780 790 800
PPVSPQAGEG VCVTGESASS TRDLLSQFGE ASLGLRCLEP PCSRWTLASF
810 820 830 840 850
AEKHYAPFLL QPTTKVVVIL LFLVLLGVSL YGTTRVRDGL ELTDIVPRET
860 870 880 890 900
SEYDFIGAQF KFFSFYNMYV VTQRAEYSQA QPLLYQLHFR FNTIRYVLRE
910 920 930 940 950
DNGQLPLMWL HYFRDWLQGL QAAFDQDWEA GRITQSSYRN GSDDGVLAYK
960 970 980 990 1000
LLVQTGRRDK PINFNQLTRQ RLVDADGIIN PGAFYIYLTA WVSNDPVAYA
1010 1020 1030 1040 1050
ASQANIRPHP PEWLHDRTDS MPETRLSIPA AEPIEYAQFP FYLNGLRETP
1060 1070 1080 1090 1100
QFVEAIESVR AICSNYSRQG LPSYPNGYPF LFWEQYVGLR HWLLLSISVV
1110 1120 1130 1140 1150
LACTFLVCAL FLLNPWTAGI IVLVLSLMTV ELFGMMGLIG IKLSAVPVVI
1160 1170 1180 1190 1200
LIASVGIGVE FTVHVALAFL TAIGDRNRRA VLALEHMFAP VLDGAFSTLL
1210 1220 1230 1240 1250
GVLMLAGSEF DFIVRYFFAV LAILTVLGVL NGLVLLPVLL SYFGPYPEVT
1260 1270 1280 1290 1300
PVDGRSRLPT PSPEPPPHVV RFSVRPRHTT SGTGTGTGSD SSDSEYSSNT
1310 1320 1330 1340 1350
TGSGISQELQ QYDLPATRGR AGRTEDMQYG TQTSRGRAVR TEEVRLGAGP
1360 1370 1380 1390 1400
RRTARQGDAT AYSVSSSVLP ESGAHPGTSR RFSKRDLQSL PPARPRMDAF
1410 1420 1430 1440 1450
EDATEAGGHY SSGGHFGSGG HRERSAGHRT RPSHNPRPNH HQPHHPNPAP
1460 1470 1480 1490 1500
TYCQPITTVT ASASVTVAVH SAPPPTQSPT SSYPGHTAAN SYHTAGGAEP
1510 1520 1530 1540
VPTFQDPHVP LEVHISRRGT KMEAMELQDV ECEAAESDCG KRAS
Length:1,544
Mass (Da):170,185
Last modified:April 12, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0551A65C9F5E9F2A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1S3PFN9A0A1S3PFN9_SALSA
protein patched homolog 1 isoform X...
ptch1
1,489Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_014026517.1, XM_014171042.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
106585152

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sasa:106585152

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_014026517.1, XM_014171042.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi106585152
KEGGisasa:106585152

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5727

Phylogenomic databases

OrthoDBi1190129at2759

Family and domain databases

InterProiView protein in InterPro
IPR003392, Ptc/Disp
IPR000731, SSD
IPR004766, TM_rcpt_patched
PfamiView protein in Pfam
PF02460, Patched, 1 hit
PF12349, Sterol-sensing, 1 hit
TIGRFAMsiTIGR00918, 2A060602, 1 hit
PROSITEiView protein in PROSITE
PS50156, SSD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1S3PFX8_SALSA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1S3PFX8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: February 10, 2021
This is version 13 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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