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UniProtKB - A0A1S3P1B2 (A0A1S3P1B2_SALSA)

Entry version 19 (10 Feb 2021)
Sequence version 1 (12 Apr 2017)
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Protein
Submitted name:

zinc finger protein GLI1

Gene

gli1

Organism
Salmo salar (Atlantic salmon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
zinc finger protein GLI1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gli1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmo salar (Atlantic salmon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8030 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Protacanthopterygii › Salmoniformes › Salmonidae › Salmoninae › Salmo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000087266 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini53 – 85C2H2-typeInterPro annotationAdd BLAST33
Domaini91 – 118C2H2-typeInterPro annotationAdd BLAST28
Domaini119 – 148C2H2-typeInterPro annotationAdd BLAST30
Domaini149 – 179C2H2-typeInterPro annotationAdd BLAST31
Domaini180 – 210C2H2-typeInterPro annotationAdd BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 46DisorderedSequence analysisAdd BLAST46
Regioni193 – 234DisorderedSequence analysisAdd BLAST42
Regioni254 – 290DisorderedSequence analysisAdd BLAST37
Regioni303 – 327DisorderedSequence analysisAdd BLAST25
Regioni395 – 487DisorderedSequence analysisAdd BLAST93
Regioni503 – 524DisorderedSequence analysisAdd BLAST22
Regioni563 – 588DisorderedSequence analysisAdd BLAST26
Regioni829 – 922DisorderedSequence analysisAdd BLAST94
Regioni1210 – 1249DisorderedSequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi193 – 220PolyampholyteSequence analysisAdd BLAST28
Compositional biasi261 – 290PolarSequence analysisAdd BLAST30
Compositional biasi410 – 444PolarSequence analysisAdd BLAST35
Compositional biasi832 – 909PolarSequence analysisAdd BLAST78
Compositional biasi1222 – 1248PolarSequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GLI C2H2-type zinc-finger protein family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		135929at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043359, GLI-like
IPR032850, GLI1
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

The PANTHER Classification System

More...PANTHERi		PTHR45718, PTHR45718, 1 hit
PTHR45718:SF2, PTHR45718:SF2, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 4 hits
PS50157, ZINC_FINGER_C2H2_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1S3P1B2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGINIKSLE ERSEGDVASP SSTGTQDPLM GLLEGREDLD KEDKPEPEAI 
        60         70         80         90        100
YETNCHWESC SKEFDTQEQL VHHINNEHIH GEKKEFVCHW QECSREQRPF 
       110        120        130        140        150
KAQYMLVVHM RRHTGEKPHK CTFEGCNKAY SRLENLKTHL RSHTGEKPYV 
       160        170        180        190        200
CEHEGCNKAF SNASDRAKHQ NRTHSNEKPY VCKIPGCTKR YTDPSSLRKH 
       210        220        230        240        250
VKTVHGPEAH ITKKHRGDTG PRPPGSSLTP GGQSGELLLE KEETRHREDC 
       260        270        280        290        300
KLLAPESALK SQPSPGGQSS CSSERSPLGS ANNNDSGVEM NLNAAGSLED 
       310        320        330        340        350
LTALEDGGAG GGGEAGGRGQ GMAGMGGTSA QALKRLENLK IDKLKQIRRP 
       360        370        380        390        400
TPPGRCGRSS KLPALTGCPG EMMGGMCTPS PLLSNRRVME LSNHELGGGP 
       410        420        430        440        450
SGMPPPISDR RGSGTSSLSS AYTVSRRSSM VSPYLSSRRS SEVSQLGGGG 
       460        470        480        490        500
GGFLGPDQGG GDPLSPETSR RRGPCHGVGG GGGLPGLPCL TPAQQYSLKA 
       510        520        530        540        550
KYAAATGGPP PTPLPSMEQG AGTPGRRGVL LSEYQGQPLP AFLQQGGQRR 
       560        570        580        590        600
HSANTGEYGT GVIYPHQAPG NATRRASDPI RSTGDPQALP KVQRFNSLNN 
       610        620        630        640        650
VAMMGRRNAL QHCGSDANIA RHMYSPRPPR ITENVLMEAM ATDYHGGTMD 
       660        670        680        690        700
ARNHCMMLSP GERGFLGYQS HHMGGPTSLL SPSHDSLGCP EQGYQTQGQM 
       710        720        730        740        750
FMQGGHHQGT SRGPGQGQMG QGGPIHPEGM SKILLQQAEY SMSTCQLSPS 
       760        770        780        790        800
GPHYPSLDQG GPDVGTGAWI ESSQVQTTHE VLQTEMQYQD QGSMQGQTQG 
       810        820        830        840        850
LYTQEPDGGH KLIIKPEQQQ YHPALANPDA CQKQLHQHQQ QRPHPGQTPM 
       860        870        880        890        900
PMRPMSSQSG YPQQGQPGQG MMRTTNPSCD FHGGGMENQN QASMQQGKQQ 
       910        920        930        940        950
GSFPQSGGIS LGSAALGAGG RSQTPMMQVK EMMVRNYVQS QQALMWGQEQ 
       960        970        980        990       1000
DQRGIGVDGK PLPLSDSMDM TGQQVAMMQQ QHSPQHQHNL YPNPGSSYPG 
      1010       1020       1030       1040       1050
YPTNQNLMSS PAHNRVPSSG SSIPPTEVPM TGLPGGPGSC YGQDMGAPVV 
      1060       1070       1080       1090       1100
PRPPQCRKPL SRQNSLQSQG GGAYLGSPPH LSPVHSTSSP RRVVRLPPVQ 
      1110       1120       1130       1140       1150
GHMTPHQTHQ EIFPPLNNIN NNMYYSGQIH LQHSDMDKQQ IQQISHPHQD 
      1160       1170       1180       1190       1200
PTQTGPCLNQ HQHQQHMVTH MDHQGNKSAS LAYLHESTPI SNALENLDLD 
      1210       1220       1230       1240       1250
NAQIDFTSII DDPDPSSFSP INPPLHGGSS QTSSRLTTPQ TSITMPPSGL 
      1260       1270 
PNMAVGDMTS MLTSLAGENK YLNTLS
Length:1,276
Mass (Da):137,485
Last modified:April 12, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i79F719C975A0E91B
GO

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_014021423.1, XM_014165948.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		106582669

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sasa:106582669

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_014021423.1, XM_014165948.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

GeneIDi106582669
KEGGisasa:106582669

Phylogenomic databases

OrthoDBi135929at2759

Family and domain databases

InterProiView protein in InterPro
IPR043359, GLI-like
IPR032850, GLI1
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PANTHERiPTHR45718, PTHR45718, 1 hit
PTHR45718:SF2, PTHR45718:SF2, 1 hit
PfamiView protein in Pfam
PF00096, zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 5 hits
SUPFAMiSSF57667, SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 4 hits
PS50157, ZINC_FINGER_C2H2_2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1S3P1B2_SALSA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1S3P1B2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: February 10, 2021
This is version 19 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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