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Entry version 21 (10 Feb 2021)
Sequence version 1 (12 Apr 2017)
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Protein
Submitted name:

low-density lipoprotein receptor-related protein 2 isoform X1

Gene

lrp2

Organism
Salmo salar (Atlantic salmon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImportedARBA annotation
Biological processEndocytosisARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
low-density lipoprotein receptor-related protein 2 isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lrp2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmo salar (Atlantic salmon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8030 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000087266 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4466 – 4489HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 35Sequence analysisAdd BLAST35
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501018272236 – 4703Sequence analysisAdd BLAST4668

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi38 ↔ 50PROSITE-ProRule annotation
Disulfide bondi45 ↔ 63PROSITE-ProRule annotation
Disulfide bondi57 ↔ 72PROSITE-ProRule annotation
Disulfide bondi118 ↔ 130PROSITE-ProRule annotation
Disulfide bondi125 ↔ 143PROSITE-ProRule annotation
Disulfide bondi137 ↔ 152PROSITE-ProRule annotation
Disulfide bondi162 ↔ 180PROSITE-ProRule annotation
Disulfide bondi174 ↔ 189PROSITE-ProRule annotation
Disulfide bondi193 ↔ 205PROSITE-ProRule annotation
Disulfide bondi200 ↔ 218PROSITE-ProRule annotation
Disulfide bondi212 ↔ 227PROSITE-ProRule annotation
Disulfide bondi232 ↔ 244PROSITE-ProRule annotation
Disulfide bondi239 ↔ 257PROSITE-ProRule annotation
Disulfide bondi251 ↔ 266PROSITE-ProRule annotation
Disulfide bondi359 ↔ 369PROSITE-ProRule annotation
Disulfide bondi677 ↔ 687PROSITE-ProRule annotation
Disulfide bondi1033 ↔ 1045PROSITE-ProRule annotation
Disulfide bondi1040 ↔ 1058PROSITE-ProRule annotation
Disulfide bondi1052 ↔ 1067PROSITE-ProRule annotation
Disulfide bondi1075 ↔ 1087PROSITE-ProRule annotation
Disulfide bondi1082 ↔ 1100PROSITE-ProRule annotation
Disulfide bondi1094 ↔ 1109PROSITE-ProRule annotation
Disulfide bondi1117 ↔ 1129PROSITE-ProRule annotation
Disulfide bondi1124 ↔ 1142PROSITE-ProRule annotation
Disulfide bondi1136 ↔ 1151PROSITE-ProRule annotation
Disulfide bondi1157 ↔ 1169PROSITE-ProRule annotation
Disulfide bondi1164 ↔ 1182PROSITE-ProRule annotation
Disulfide bondi1176 ↔ 1191PROSITE-ProRule annotation
Disulfide bondi1215 ↔ 1230PROSITE-ProRule annotation
Disulfide bondi1287 ↔ 1299PROSITE-ProRule annotation
Disulfide bondi1294 ↔ 1312PROSITE-ProRule annotation
Disulfide bondi1306 ↔ 1321PROSITE-ProRule annotation
Disulfide bondi1415 ↔ 1425PROSITE-ProRule annotation
Disulfide bondi2720 ↔ 2732PROSITE-ProRule annotation
Disulfide bondi2727 ↔ 2745PROSITE-ProRule annotation
Disulfide bondi2783 ↔ 2795PROSITE-ProRule annotation
Disulfide bondi2790 ↔ 2808PROSITE-ProRule annotation
Disulfide bondi2802 ↔ 2817PROSITE-ProRule annotation
Disulfide bondi2830 ↔ 2848PROSITE-ProRule annotation
Disulfide bondi2906 ↔ 2918PROSITE-ProRule annotation
Disulfide bondi2913 ↔ 2931PROSITE-ProRule annotation
Disulfide bondi2948 ↔ 2960PROSITE-ProRule annotation
Disulfide bondi2955 ↔ 2973PROSITE-ProRule annotation
Disulfide bondi3035 ↔ 3047PROSITE-ProRule annotation
Disulfide bondi3042 ↔ 3060PROSITE-ProRule annotation
Disulfide bondi3054 ↔ 3069PROSITE-ProRule annotation
Disulfide bondi3074 ↔ 3086PROSITE-ProRule annotation
Disulfide bondi3081 ↔ 3099PROSITE-ProRule annotation
Disulfide bondi3117 ↔ 3129PROSITE-ProRule annotation
Disulfide bondi3124 ↔ 3142PROSITE-ProRule annotation
Disulfide bondi3136 ↔ 3151PROSITE-ProRule annotation
Disulfide bondi3594 ↔ 3606PROSITE-ProRule annotation
Disulfide bondi3601 ↔ 3619PROSITE-ProRule annotation
Disulfide bondi3635 ↔ 3647PROSITE-ProRule annotation
Disulfide bondi3642 ↔ 3660PROSITE-ProRule annotation
Disulfide bondi3676 ↔ 3688PROSITE-ProRule annotation
Disulfide bondi3683 ↔ 3701PROSITE-ProRule annotation
Disulfide bondi3740 ↔ 3755PROSITE-ProRule annotation
Disulfide bondi3768 ↔ 3786PROSITE-ProRule annotation
Disulfide bondi3780 ↔ 3795PROSITE-ProRule annotation
Disulfide bondi3800 ↔ 3812PROSITE-ProRule annotation
Disulfide bondi3807 ↔ 3825PROSITE-ProRule annotation
Disulfide bondi3819 ↔ 3834PROSITE-ProRule annotation
Disulfide bondi3839 ↔ 3851PROSITE-ProRule annotation
Disulfide bondi3846 ↔ 3864PROSITE-ProRule annotation
Disulfide bondi3858 ↔ 3873PROSITE-ProRule annotation
Disulfide bondi3883 ↔ 3895PROSITE-ProRule annotation
Disulfide bondi3890 ↔ 3908PROSITE-ProRule annotation
Disulfide bondi3932 ↔ 3950PROSITE-ProRule annotation
Disulfide bondi3969 ↔ 3981PROSITE-ProRule annotation
Disulfide bondi3976 ↔ 3994PROSITE-ProRule annotation
Disulfide bondi3988 ↔ 4003PROSITE-ProRule annotation
Disulfide bondi4443 ↔ 4452PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation, LipoproteinImported

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini355 – 393EGF-likeInterPro annotationAdd BLAST39
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati443 – 485LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati486 – 528LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati529 – 575LDL-receptor class BPROSITE-ProRule annotationAdd BLAST47
Repeati576 – 620LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Domaini673 – 712EGF-likeInterPro annotationAdd BLAST40
Repeati760 – 802LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati803 – 844LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Repeati845 – 888LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati889 – 932LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Domaini1411 – 1450EGF-likeInterPro annotationAdd BLAST40
Repeati1499 – 1541LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1542 – 1584LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1587 – 1630LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati1631 – 1675LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati1676 – 1716LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Repeati1811 – 1853LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1854 – 1903LDL-receptor class BPROSITE-ProRule annotationAdd BLAST50
Repeati1904 – 1951LDL-receptor class BPROSITE-ProRule annotationAdd BLAST48
Repeati1952 – 1993LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Repeati1994 – 2034LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Repeati2128 – 2177LDL-receptor class BPROSITE-ProRule annotationAdd BLAST50
Repeati2178 – 2222LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati2223 – 2266LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati2267 – 2310LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati2311 – 2353LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati2452 – 2498LDL-receptor class BPROSITE-ProRule annotationAdd BLAST47
Repeati2499 – 2539LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Repeati2540 – 2583LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati2584 – 2625LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Repeati2626 – 2667LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Domaini3152 – 3193EGF-likeInterPro annotationAdd BLAST42
Domaini3194 – 3227EGF-likeInterPro annotationAdd BLAST34
Repeati3281 – 3322LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Repeati3323 – 3365LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati3374 – 3417LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati3418 – 3460LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati3461 – 3501LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Domaini4007 – 4047EGF-likeInterPro annotationAdd BLAST41
Repeati4140 – 4194LDL-receptor class BPROSITE-ProRule annotationAdd BLAST55
Repeati4195 – 4237LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati4238 – 4281LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati4283 – 4325LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Domaini4419 – 4453EGF-likeInterPro annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni4640 – 4703DisorderedSequence analysisAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4640 – 4668PolarSequence analysisAdd BLAST29

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
1606at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112, LDLa, 36 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 8 hits
4.10.400.10, 35 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07645, EGF_CA, 4 hits
PF00057, Ldl_recept_a, 33 hits
PF00058, Ldl_recept_b, 17 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261, LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 24 hits
SM00179, EGF_CA, 10 hits
SM00192, LDLa, 36 hits
SM00135, LY, 39 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184, SSF57184, 4 hits
SSF57424, SSF57424, 36 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 3 hits
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 6 hits
PS50026, EGF_3, 7 hits
PS01187, EGF_CA, 3 hits
PS01209, LDLRA_1, 19 hits
PS50068, LDLRA_2, 36 hits
PS51120, LDLRB, 37 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A1S3NVW5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSWTDQPGP SIRMWRAVLA KLLVILIFCT FRCHSQGCET GQFRCGTGRC
60 70 80 90 100
IPQHWRCDGT LDCVDDSDEA DCPLVTCDES HFQCLSDGEC VPDVWVCDDE
110 120 130 140 150
EDCEDGSDER HRCPGRMCSS GQFSCTNGAC IPGEYRCDRL PDCSDGADER
160 170 180 190 200
DCHYPECTEL RCANSACYNR TQHCDLVMDC RDGSDEANCT QHCSSGLFQC
210 220 230 240 250
GNGECVPQRY VCDHDDDCGD RSDEQSCTYP TCRGSYFTCP SGRCVHQVWL
260 270 280 290 300
CDGEDDCEDN ADEKGCDAVS RECYPGEWPC PSSGLCIPMD QLCDGTAQCP
310 320 330 340 350
DGEDETNATA GRNCSIWRCA SLSCEHRCHA SPEGGTCTCP SGYTVNNNNS
360 370 380 390 400
RSCIDFDDCQ MWGVCDQLCE DRIGTHRCSC REGYFLEQHR YCRANTSTSV
410 420 430 440 450
ASLVFSNGQD LLIGDIHGHS SRTLVHSQNR GVPVGVDFHY LLNRVFWTDT
460 470 480 490 500
IQNKVFSVDM DGSNMQVILN VSVDYPENLA VDWVNNKLYV VEASVNRIDM
510 520 530 540 550
VDFDGNNRVT LIAENLGNPR GLAVDPTVGF LFFSDWDSLN GEPGLERAYM
560 570 580 590 600
DGTNRYGIIR TKLGWPAGIT LDIDAKRVYW VDSRYDYIET TTYDGLHRKT
610 620 630 640 650
VVHGGAVIPH PFGISLFEHT VYFTDWTKMA VMKANKFSDT NPQVVYTTSQ
660 670 680 690 700
TPHGVQVVHQ LRQPYVANPC GVDRDGCEQI CILSHRSDNQ GLGYRCRCRM
710 720 730 740 750
GYDLHADGKR CVAVRQFLLF SSQLAVRGIP FNLSSQEDVI LPVTGTPSYF
760 770 780 790 800
VGVDFSAEDD AIFFSDTAKD IIYKQKVDGT GREVLAANRV DGVEDLAFDW
810 820 830 840 850
ISKNLYWTDP RFRSISVMKV ADQSRRAIIR NLNNPRSIVV HPVIGYIFWT
860 870 880 890 900
DWYRPAKIMR AWCDGSHALS IVNTTLGWPN GLAIDWSSMR LYWVDAFFDK
910 920 930 940 950
IEHSTFDGQN RLSLERITQI SHPFGLTIFG GYAYFTDWRL GGIVRVRKTD
960 970 980 990 1000
GGEMVIIRRG ISHIMHVKTF NYNSQTGSNF CNRNTNPNGD CSHFCFPVPD
1010 1020 1030 1040 1050
SQRVCGCPYG MKLAPSQQTC VEDPSNEPPT LQCGSNSFSC TNGKCVPQNY
1060 1070 1080 1090 1100
RCDGVDDCHD NSDEANCGGA HNTTCSPRAF TCANQHCVPS GWHCDGHNDC
1110 1120 1130 1140 1150
FDSSDEQDCP TQTPGTCAAN QFTCANNRCI PHVWLCDTDN DCGDGSDEAN
1160 1170 1180 1190 1200
CNLSGTCHPE QFQCPDHRCI GPSYVCDGDR DCTDGADEQG CIYNCTLYEF
1210 1220 1230 1240 1250
KCSNGHQCIN SYYRCDGVFD CSDHSDESGC HDREPLPATR PPGMCHHESE
1260 1270 1280 1290 1300
FQCQSDGSCI PSTWECDGHP DCEDGSDEHH VCPLRTCPTT LFRCDNGNCV
1310 1320 1330 1340 1350
YQRWLCDGDN DCRDMSDERD CPTPPFRCPS WQWQCPGHSM CVNISRVCDN
1360 1370 1380 1390 1400
NPDCPNGADE SPLCNEPLPD QESCTDNNAG CTHGCIQGPF GAQCTCPMGY
1410 1420 1430 1440 1450
HLSNDSKTCD DIDECSPPGL CSQHCFNERG SFRCHCSDGY TLEADQRTCK
1460 1470 1480 1490 1500
VSGSREAFLL VASRNQIVSD DITTQPNVVR SLVRDGRNIV ALDFDSVTDR
1510 1520 1530 1540 1550
VYWSDTSQDR IWSAHKNGSD RAVVFDSGVT VTESLAVDWV GRNLYWTDYV
1560 1570 1580 1590 1600
LETIEVSKLD GTHRTVLVSE NVTNPRAIVL DPRDSAHLMF WTDWGRNPRI
1610 1620 1630 1640 1650
EKASMDGKMR TTIISNKLYW PNGLTIDYPN NLLYFADAYL DFIDYCDYNG
1660 1670 1680 1690 1700
KNRKQVLASD LVLQHPHAIT IFEDFVYWTD RYINRVIRAH KWHGENQTVM
1710 1720 1730 1740 1750
LYNLPQPMGL VAVHPSRQPA GENHCFSSPC SHICLLSAVG PSFYSCACPS
1760 1770 1780 1790 1800
GCTLAADQIT CARVEDPFLV VVRDSVIYGI PLNPDVKSND AMVPVAGLQN
1810 1820 1830 1840 1850
GYDVDFDITE QTIYWVEHPG EIHRVKSDGT NRTEFAPAAI LGSPVGLALD
1860 1870 1880 1890 1900
WITENLYYTN PATQSIEVLR LRGEMQYRKT LITNNGSPTG AGTPVGIAVD
1910 1920 1930 1940 1950
PARGKLYWTD QGTESGIPAK VAAADLDGSN PVTLFTNNLD QVEFITVDIS
1960 1970 1980 1990 2000
ENKLYWAVTG AGMIERGDPD GTNRITIVTG LSHPWGVAVH ESFLYFTDRD
2010 2020 2030 2040 2050
FEVIERVDKA TGANKVVLRD NVSGLRVLKV HYRETSAGTS NGCSNNMGLC
2060 2070 2080 2090 2100
EHLCLPRPGG LYTCACATGF KLSADNRTCA SYQSYVVISM LSALKGFSLE
2110 2120 2130 2140 2150
GADHSEAMVP VAGRGRNALH VDVHMASGFL YWCDFSSTVT SQNGIRRIKS
2160 2170 2180 2190 2200
DGAGFDSVVT SGIGRNGIRG IAVDWAAGNL YFTNAFLTET YVEVLRLNTT
2210 2220 2230 2240 2250
FRRVLLKTQV DMPRHIVVDP KNRYLFWADY GQNPKIERAL LDGTNRTVLV
2260 2270 2280 2290 2300
SSGIITPRGL ALDYQTGYVY WVDDSLDMIA RVNPQGGETE VVRYGSRYPT
2310 2320 2330 2340 2350
PYGITVFETS IIWVDRNLKK VFQASKEPGS TEQPAVIRDN INMLRDVTIY
2360 2370 2380 2390 2400
DQRIQPSSAQ QLNNNPCLET NGGCAHFCFA LPGNQTKKCG CAFGNLGTDN
2410 2420 2430 2440 2450
EGCVVSRDDY LIYTTESAVQ SLHLDTDDHG LPFPVVNVPG TSVALDFDRT
2460 2470 2480 2490 2500
DNRIYFTQSS GAGSSKISFI SLSSPTSPPV VVASDLGAPD GIAYDWINKR
2510 2520 2530 2540 2550
IYYSDYINQT INSMAVDGTQ RSIIAHVPRP RAIMLDPCRG YMYWTDWGTN
2560 2570 2580 2590 2600
AKIERSTLGG NFRAEIVNSS LVWPNGLTLD YEEQRLYWAD ASLQKIERCS
2610 2620 2630 2640 2650
LTGANREVIV STAIYPFAMT MYGQYIYWTD WNTRSIYRAN KHDGSDQRVM
2660 2670 2680 2690 2700
TQNLPSRPMD VHVLASNKQQ QCNSPCQQFN GGCSHICTPG PQGAECQCPS
2710 2720 2730 2740 2750
EGRWYLADNK HCIPDNGTRC QEGQFTCMNG RCIRAQWKCD NDNDCGDGSD
2760 2770 2780 2790 2800
ELERVCGSKN DFQTSVQVQM AAAFIALSAF HTCEPTVFTC GNGRCVPYHY
2810 2820 2830 2840 2850
RCDHYNDCGD NSDEVGCLFS PCDPNTEFPC NNGRCISKDY ICNGINNCYD
2860 2870 2880 2890 2900
NGTSDEQNCP ERTCQPEHTK CTSTNICIPR SYLCDGDNDC GDMSDESPTH
2910 2920 2930 2940 2950
CATSTCAQNE FRCSSGRCIP AHWYCDGGTD CADGSDEPSS CTTLVRTCNT
2960 2970 2980 2990 3000
DQFPCDDGRC IASSWICDGD NDCGDMSDED QRHNCDNRTC SVLEFTCVNN
3010 3020 3030 3040 3050
QAPQRKCIPR DWVCDGDADC ADALDEHQNC TRRSCGVNEF TCSNGLCIRS
3060 3070 3080 3090 3100
SYRCDRRNDC GDSSDEQGCT YQPCQQHQFI CQNGRCVSRD FICDGDNDCG
3110 3120 3130 3140 3150
DESDELDHLC RTPPPTCPPG QFRCDNGHCV PLFNVCDRTD DCSDNSDEKG
3160 3170 3180 3190 3200
CGINECTNPS MHHCDHNCTD TPTSFICTCR PGYRLMSDNK TCDDVNECAE
3210 3220 3230 3240 3250
TPSVCSQVCE NTVGSYMCKC APGFLREPDG HSCRQNSNIT PYLIFSNRYY
3260 3270 3280 3290 3300
LRNLSTDGEA YSLILQGLTS VVAMDFDRVD KRFYWIDVSR RLIERMFYNG
3310 3320 3330 3340 3350
SNREVVVNGV LHGEGLAVDW VARKLYWLDS FLDCLKVSEL DGRFVKKLAE
3360 3370 3380 3390 3400
HCVDANNTYC FENPRALVLH PKYGYVYWTD WGDKAFIGRV GMDGTNKTTI
3410 3420 3430 3440 3450
ITTKIEWPNG VTIDYSNDKL YWSDAHLNYI EFSDLEGHHR HTVYDGILPH
3460 3470 3480 3490 3500
PFALTVFEET VYWTDWNTRT VEKGNKYDGS GRQSLVNTTH RPFDIHVCHP
3510 3520 3530 3540 3550
YRQPIVTNPC AVNNGGCSHL CLLRDGGRGH TCECPDHFLT LQLGGVARCL
3560 3570 3580 3590 3600
PMCTSTQYRC ADNERCIPIW WKCDGQRDCR DGSDEPSTCP SRHCQLGQFQ
3610 3620 3630 3640 3650
CNDGNCTSPH FLCNSNQDCH DGSDEDPVLC ATHQCETHQW QCTNKRCVPE
3660 3670 3680 3690 3700
AWQCDGEDDC GDGSDEEPTH CSSRTCRPGQ SKCRNGRCIP QNWKCDVDDD
3710 3720 3730 3740 3750
CGDNSDEPLD ECMGPSYRCD NHTQFDCRTN YRCVPLWSVC NGHNDCRDNS
3760 3770 3780 3790 3800
DEQGCEEVTC DPLGDFRCDN HQCVPLRWRC DGDNDCGDSS DERACSPRVC
3810 3820 3830 3840 3850
SESEFRCDNL HCIPDRWVCD HDNDCEDNSD ERDCELRTCH MGYFQCGSGH
3860 3870 3880 3890 3900
CIADRFKCDG NADCMDYTDE ISCPTRYPNG TYCPPFLFEC RNHVCVQPYW
3910 3920 3930 3940 3950
KCDGDNDCGD NSDEELHLCL DIPCDTPFRF RCDNNRCIYS HELCNSVDDC
3960 3970 3980 3990 4000
GDGTDEKEEH CQTPTHGPCS ADEYKCSNGQ CIPLQYTCDD YDDCGDHSDE
4010 4020 4030 4040 4050
LGCNVGSGRS CSDNICEHNC TDLTDGGFLC SCKPGYKPSQ IDRNTCEDVN
4060 4070 4080 4090 4100
ECEVYGTCPQ ECQNSKGSYE CFCAQGFRSV SEQHGMECAA EGYPPVLLLP
4110 4120 4130 4140 4150
DNVRIRCFNL SSEQYSDYVD NMEHIQALDY LWDPEGIGLS IVYWTVLGRG
4160 4170 4180 4190 4200
SQFGSIKRAY MTTFNDNGNN PVKELDLNLR YIANPDGIAV DWIGGHIYWT
4210 4220 4230 4240 4250
DAGTNRIEVA KLDGRYRKWL IHTDLDQPAA IVVNPALGLM YWTDWGRRPR
4260 4270 4280 4290 4300
IESAWMDGQH RQVLLDEDLG WPTGLALDYL NGDRIYWCDS KENIIESMKP
4310 4320 4330 4340 4350
DGTERKIIMS GDIGNPYSLD VFEGHVYWTT KERGEVWKTD KFGKGDKVKV
4360 4370 4380 4390 4400
LTINPWLTQV RIYQEHRHNR SVPNPCKNMC SHLCLLRPGG YTCTCPQGSS
4410 4420 4430 4440 4450
LVGFNPNECD AAIEAPVLMP LACRCMNGGT CYTDEGGLPK CKCPYGYAGS
4460 4470 4480 4490 4500
YCEMGKSRGA PAGTAVAVLL AVIIILITGA LAVGVFLNYK RTGSLIPSMP
4510 4520 4530 4540 4550
KLPSLSSLVK SGDTGNGVTF RSGDNVTMDL GPPPIGVSFI DRAMQLDENF
4560 4570 4580 4590 4600
AVEAGRQPIT FENPLYATAA AGSSSDPAVI HATQVTVTVS GEQIEKNFAN
4610 4620 4630 4640 4650
PAYHTDQIVC TVDSSTARAK PVQESRWSFF KRKFKPSTTF ENPTYSEMQN
4660 4670 4680 4690 4700
EKAVGSNEES SSTDPSPFAP TAKPFKRDRP STYSPTEDTF RDTANLVKED

SDV
Length:4,703
Mass (Da):524,528
Last modified:April 12, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i04C2405A4C1B6B90
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1S3NVW6A0A1S3NVW6_SALSA
low-density lipoprotein receptor-re...
lrp2
4,696Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1S3NVX0A0A1S3NVX0_SALSA
low-density lipoprotein receptor-re...
lrp2
4,674Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1S3NWA3A0A1S3NWA3_SALSA
low-density lipoprotein receptor-re...
lrp2
4,690Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1S3NWC8A0A1S3NWC8_SALSA
low-density lipoprotein receptor-re...
lrp2
4,681Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_014019552.1, XM_014164077.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
106581783

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sasa:106581783

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_014019552.1, XM_014164077.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi106581783
KEGGisasa:106581783

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
568184

Phylogenomic databases

OrthoDBi1606at2759

Family and domain databases

CDDicd00112, LDLa, 36 hits
Gene3Di2.120.10.30, 8 hits
4.10.400.10, 35 hits
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt
PfamiView protein in Pfam
PF07645, EGF_CA, 4 hits
PF00057, Ldl_recept_a, 33 hits
PF00058, Ldl_recept_b, 17 hits
PRINTSiPR00261, LDLRECEPTOR
SMARTiView protein in SMART
SM00181, EGF, 24 hits
SM00179, EGF_CA, 10 hits
SM00192, LDLa, 36 hits
SM00135, LY, 39 hits
SUPFAMiSSF57184, SSF57184, 4 hits
SSF57424, SSF57424, 36 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 3 hits
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 6 hits
PS50026, EGF_3, 7 hits
PS01187, EGF_CA, 3 hits
PS01209, LDLRA_1, 19 hits
PS50068, LDLRA_2, 36 hits
PS51120, LDLRB, 37 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1S3NVW5_SALSA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1S3NVW5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: February 10, 2021
This is version 21 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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