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Entry version 21 (10 Feb 2021)
Sequence version 1 (12 Apr 2017)
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Protein
Submitted name:

low-density lipoprotein receptor-related protein 2-like

Gene

LOC106579098

Organism
Salmo salar (Atlantic salmon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImportedARBA annotation
Biological processEndocytosisARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
low-density lipoprotein receptor-related protein 2-likeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC106579098Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmo salar (Atlantic salmon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8030 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000087266 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4409 – 4437HelicalSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501021189224 – 4616Sequence analysisAdd BLAST4593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi25 ↔ 37PROSITE-ProRule annotation
Disulfide bondi32 ↔ 50PROSITE-ProRule annotation
Disulfide bondi44 ↔ 59PROSITE-ProRule annotation
Disulfide bondi105 ↔ 117PROSITE-ProRule annotation
Disulfide bondi112 ↔ 130PROSITE-ProRule annotation
Disulfide bondi124 ↔ 139PROSITE-ProRule annotation
Disulfide bondi149 ↔ 167PROSITE-ProRule annotation
Disulfide bondi161 ↔ 176PROSITE-ProRule annotation
Disulfide bondi181 ↔ 193PROSITE-ProRule annotation
Disulfide bondi188 ↔ 206PROSITE-ProRule annotation
Disulfide bondi200 ↔ 215PROSITE-ProRule annotation
Disulfide bondi220 ↔ 232PROSITE-ProRule annotation
Disulfide bondi227 ↔ 245PROSITE-ProRule annotation
Disulfide bondi239 ↔ 254PROSITE-ProRule annotation
Disulfide bondi346 ↔ 356PROSITE-ProRule annotation
Disulfide bondi1021 ↔ 1033PROSITE-ProRule annotation
Disulfide bondi1028 ↔ 1046PROSITE-ProRule annotation
Disulfide bondi1040 ↔ 1055PROSITE-ProRule annotation
Disulfide bondi1062 ↔ 1074PROSITE-ProRule annotation
Disulfide bondi1069 ↔ 1087PROSITE-ProRule annotation
Disulfide bondi1081 ↔ 1096PROSITE-ProRule annotation
Disulfide bondi1124 ↔ 1139PROSITE-ProRule annotation
Disulfide bondi1146 ↔ 1158PROSITE-ProRule annotation
Disulfide bondi1153 ↔ 1171PROSITE-ProRule annotation
Disulfide bondi1165 ↔ 1180PROSITE-ProRule annotation
Disulfide bondi1204 ↔ 1219PROSITE-ProRule annotation
Disulfide bondi1268 ↔ 1280PROSITE-ProRule annotation
Disulfide bondi1275 ↔ 1293PROSITE-ProRule annotation
Disulfide bondi1287 ↔ 1302PROSITE-ProRule annotation
Disulfide bondi1391 ↔ 1401PROSITE-ProRule annotation
Disulfide bondi2695 ↔ 2707PROSITE-ProRule annotation
Disulfide bondi2702 ↔ 2720PROSITE-ProRule annotation
Disulfide bondi2736 ↔ 2748PROSITE-ProRule annotation
Disulfide bondi2743 ↔ 2761PROSITE-ProRule annotation
Disulfide bondi2755 ↔ 2770PROSITE-ProRule annotation
Disulfide bondi2783 ↔ 2801PROSITE-ProRule annotation
Disulfide bondi2859 ↔ 2871PROSITE-ProRule annotation
Disulfide bondi2866 ↔ 2884PROSITE-ProRule annotation
Disulfide bondi2901 ↔ 2913PROSITE-ProRule annotation
Disulfide bondi2908 ↔ 2926PROSITE-ProRule annotation
Disulfide bondi2989 ↔ 3001PROSITE-ProRule annotation
Disulfide bondi2996 ↔ 3014PROSITE-ProRule annotation
Disulfide bondi3008 ↔ 3023PROSITE-ProRule annotation
Disulfide bondi3028 ↔ 3040PROSITE-ProRule annotation
Disulfide bondi3035 ↔ 3053PROSITE-ProRule annotation
Disulfide bondi3071 ↔ 3083PROSITE-ProRule annotation
Disulfide bondi3078 ↔ 3096PROSITE-ProRule annotation
Disulfide bondi3090 ↔ 3105PROSITE-ProRule annotation
Disulfide bondi3549 ↔ 3561PROSITE-ProRule annotation
Disulfide bondi3556 ↔ 3574PROSITE-ProRule annotation
Disulfide bondi3590 ↔ 3602PROSITE-ProRule annotation
Disulfide bondi3597 ↔ 3615PROSITE-ProRule annotation
Disulfide bondi3631 ↔ 3643PROSITE-ProRule annotation
Disulfide bondi3638 ↔ 3656PROSITE-ProRule annotation
Disulfide bondi3695 ↔ 3710PROSITE-ProRule annotation
Disulfide bondi3723 ↔ 3741PROSITE-ProRule annotation
Disulfide bondi3735 ↔ 3750PROSITE-ProRule annotation
Disulfide bondi3755 ↔ 3767PROSITE-ProRule annotation
Disulfide bondi3762 ↔ 3780PROSITE-ProRule annotation
Disulfide bondi3774 ↔ 3789PROSITE-ProRule annotation
Disulfide bondi3794 ↔ 3806PROSITE-ProRule annotation
Disulfide bondi3801 ↔ 3819PROSITE-ProRule annotation
Disulfide bondi3813 ↔ 3828PROSITE-ProRule annotation
Disulfide bondi3838 ↔ 3850PROSITE-ProRule annotation
Disulfide bondi3845 ↔ 3863PROSITE-ProRule annotation
Disulfide bondi3887 ↔ 3905PROSITE-ProRule annotation
Disulfide bondi3924 ↔ 3936PROSITE-ProRule annotation
Disulfide bondi3931 ↔ 3949PROSITE-ProRule annotation
Disulfide bondi3943 ↔ 3958PROSITE-ProRule annotation
Disulfide bondi4007 ↔ 4017PROSITE-ProRule annotation
Disulfide bondi4396 ↔ 4405PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation, LipoproteinImported

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini342 – 380EGF-likeInterPro annotationAdd BLAST39
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati430 – 472LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati473 – 515LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati516 – 562LDL-receptor class BPROSITE-ProRule annotationAdd BLAST47
Repeati563 – 607LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati749 – 791LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati792 – 833LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Repeati834 – 877LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati878 – 921LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Domaini1387 – 1426EGF-likeInterPro annotationAdd BLAST40
Repeati1474 – 1516LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1517 – 1559LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1562 – 1605LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati1606 – 1650LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati1651 – 1691LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Repeati1786 – 1828LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1829 – 1878LDL-receptor class BPROSITE-ProRule annotationAdd BLAST50
Repeati1879 – 1926LDL-receptor class BPROSITE-ProRule annotationAdd BLAST48
Repeati1927 – 1968LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Repeati1969 – 2009LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Repeati2104 – 2152LDL-receptor class BPROSITE-ProRule annotationAdd BLAST49
Repeati2153 – 2197LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati2198 – 2241LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati2242 – 2285LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati2427 – 2472LDL-receptor class BPROSITE-ProRule annotationAdd BLAST46
Repeati2473 – 2513LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Repeati2514 – 2557LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati2558 – 2599LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Repeati2600 – 2641LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Domaini3148 – 3188EGF-likeInterPro annotationAdd BLAST41
Repeati3235 – 3277LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati3278 – 3305LDL-receptor class BPROSITE-ProRule annotationAdd BLAST28
Repeati3329 – 3372LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati3373 – 3415LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati3416 – 3456LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Domaini4003 – 4042EGF-likeInterPro annotationAdd BLAST40
Repeati4148 – 4190LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati4191 – 4234LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati4236 – 4278LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Domaini4373 – 4406EGF-likeInterPro annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni4459 – 4486DisorderedSequence analysisAdd BLAST28
Regioni4546 – 4616DisorderedSequence analysisAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4459 – 4473PolarSequence analysisAdd BLAST15
Compositional biasi4577 – 4591PolyampholyteSequence analysisAdd BLAST15
Compositional biasi4602 – 4616PolarSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LDLR family.ARBA annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
1606at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112, LDLa, 36 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 8 hits
4.10.400.10, 36 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR026823, cEGF
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12662, cEGF, 1 hit
PF07645, EGF_CA, 3 hits
PF00057, Ldl_recept_a, 35 hits
PF00058, Ldl_recept_b, 10 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261, LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 23 hits
SM00179, EGF_CA, 8 hits
SM00192, LDLa, 36 hits
SM00135, LY, 36 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184, SSF57184, 3 hits
SSF57424, SSF57424, 34 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 3 hits
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 5 hits
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 3 hits
PS01209, LDLRA_1, 20 hits
PS50068, LDLRA_2, 36 hits
PS51120, LDLRB, 35 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1S3NF92-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLLGLNVLS LLLLSQGIQL TQGQCDSGKF QCDNGQCIDL DWRCDGTKDC
60 70 80 90 100
TDDSDELNCP PPSCSSQQFK CVTGGECISL QFVCDGEEDC TDGSDEQRTC
110 120 130 140 150
REQTCGPYQF TCQEGQCIPK VYRCDRVKDC LDNSDENNCN YPSCTEKTCA
160 170 180 190 200
NGACYNNSQH CNGLQNCRDG SDESNCTTQQ CPLHQFQCTN GYCIPMSFIC
210 220 230 240 250
DHWDDCGDNS DEQGCEYQSC SGTQFTCPSG RCIPQSWVCD EFNDCGDYSD
260 270 280 290 300
ENGCDSNSRD CYPGEWPCPG SSMCVPVGKV CDGKPDCPRG TDETNTTAQQ
310 320 330 340 350
TCSLDQCSAL SCEYLCHFTP QGGACYCPDG FIVANDSRSC VDYDDCDIWG
360 370 380 390 400
ICDQLCEDRP GTHRCSCADG YFLEQGNRCR ANISVGLPQL IFTNGGEVMM
410 420 430 440 450
ADIHGRFIRT LVPSQGRGSS VGVGYHWHSQ RVFWTDTNTQ KVYSANFDGG
460 470 480 490 500
DIQEVLNEAV HSAQNIAVDW INFKLYVLEA RVERIDMCDF DGGNRATLVA
510 520 530 540 550
ENLLTPHGLA LDPTVGYMFF TDSGYISEDM KLERAYMDGS NRVELVKTRL
560 570 580 590 600
GMPTGVTLDI VTQRVYWSDS HFNMVETVTY SGLERKTVLN GGTQVPYPFG
610 620 630 640 650
ISVFENHLFF TDWTKMGVIR TNRFNGSDPN LIYSTADRPG HIVVAHPALQ
660 670 680 690 700
PIVMSPCGRN NGGCQHICVL SHLSDNDGLG FRCKCRLGYD LHEDRHSCFK
710 720 730 740 750
VRDYLLLATQ YAVRGIPLNV SLQEDVTLPL TGLGVTFSSS AVEFDGNEEA
760 770 780 790 800
VFYNDRSRQI IYKSNTNGSN TEILTGYRVG HAESMAYDWT SKVLFWTSSS
810 820 830 840 850
YRVVVAFRVT DKSRRDIVTG LKSPRGLAVH PSAGYLFWTD WYRPAVIMRS
860 870 880 890 900
WTDGSNAVPL INTTLGWPNG LTIDYVNDRL YWADALLDQV GHVGIDGYDR
910 920 930 940 950
QMFSNIGQIT QPFSITIHAD YLFVSDSRTR SVFRMRKRDG GEITPIRKGI
960 970 980 990 1000
SGILSVKAYT ADLHGMFNSR CNMVPNGRCS HFCFPVPSSS RVCGCPYGMK
1010 1020 1030 1040 1050
LQENQRDCVK DDSVPPIDTS CGDYSFPCDG GRCMPNSYRC DGVKDCMDQT
1060 1070 1080 1090 1100
DEANCTDTGM TCSPWAFTCD NKHCILSSWR CDGHEDCGDG SDEVNCPTRL
1110 1120 1130 1140 1150
PFTCSSEQFA CTDGSRCIPK AWTCDADKDC SDGSDERNCN GTIATCEPGY
1160 1170 1180 1190 1200
FFCPDHRCIY SSYVCDGDQD CMDGSDEKDC EFSCSSYEFA CASGDQCVSS
1210 1220 1230 1240 1250
IYRCDGVFDC RDQSDESGCP TRGPGLCHND EFQCQTDGLC VPDEWECDGH
1260 1270 1280 1290 1300
HDCEDGSDEH NSCPPVTCHI NYFQCANGNC ISPSWVCDGD NDCRDMSDEQ
1310 1320 1330 1340 1350
NCPTPPFMCP SGQWLCPTGQ VCIVLGKVCD GQRDCPNGAD ESPLCNQEDC
1360 1370 1380 1390 1400
ALNNGGCSDG CIQGPFGAEC TCQPGYQLLN DSKTCDDIDE CSIPGWCSQQ
1410 1420 1430 1440 1450
CYNERGSFRC SCSDGYILEA DSRSCKATDP TAATLLVAKR SQIISNKVNL
1460 1470 1480 1490 1500
RPPLIHPVVS GSDIVTVDFD RLTGRIYWAD ASLKKIFTSF QNGTDRREVF
1510 1520 1530 1540 1550
STGLMVPESI AVDWVARNLY WTDSVMENIE VSTLDGRFRK VLLTKNVTSP
1560 1570 1580 1590 1600
RGLALDPRNH TNVMFWSDWG QNPRIEMAYM DGTGRQAIVT TKLYWPNGLA
1610 1620 1630 1640 1650
LDYTTRRVYF ADAYLKYIDY CDYNGNNRFQ VMASDMVLQH PHGMTIFEDH
1660 1670 1680 1690 1700
IYWSERYTYQ VLRTNKFHGG NTTTMITNVY QPLGIVMDHP IKQPAAINPC
1710 1720 1730 1740 1750
AEHLCSQLCL LSGFRPRYYT CHCQSGWNLN SDGRTCIKDD TPFLMVVKET
1760 1770 1780 1790 1800
VIFGIPVDPA DPSNNAMAPV SGITQGRDID FDDQEQFVYW VQDSSSIYRV
1810 1820 1830 1840 1850
KTDGTNRTLF APSAIIGSPS GLAFDWITRT MYYTNPTNKA IEVIRVDGVQ
1860 1870 1880 1890 1900
LYRKTLITNT GKLEGAGEPI GIALDPARGK LFWTDRGTDS GVPPKVASAD
1910 1920 1930 1940 1950
MDGGNLRNLY TINQGIIGFI TADIAMSKLY WGVASTGVIE CGTMDGVSRV
1960 1970 1980 1990 2000
TIVSQLSHPW GLTVHQHYLY YTDLDYEVIE RVDKGTGANM VVLRSGMTGV
2010 2020 2030 2040 2050
RALKVHARDN SAGTTNGCST NNGACPHLCL PKPGGQKTCV CTTGLVPSKD
2060 2070 2080 2090 2100
GTTCVQYDSY AVVSTPRLIR GFHINSSDHS EAMVPVAGYS YSVMDKLDLH
2110 2120 2130 2140 2150
VASRYIYWID NSTSSSYRGI FRAQTDGGSF TPVVNQGIGR GGIKGMAVDW
2160 2170 2180 2190 2200
ISGNLYFTNA IEAQTYLEVT RLETPYRTVL LKSTEDRPSD LAVSPKLRFL
2210 2220 2230 2240 2250
FWADGGQNPK IERAQLDGAN RTVLASESLA SPRGLTVDYT NDFLYWTDDV
2260 2270 2280 2290 2300
LDMISRMAPD GTQREIVRYG SRYPAPYGLS IFGNSMLWVD RKLGKLFQAS
2310 2320 2330 2340 2350
KDPANTTQPE VIRDGIDGLT DVVVFNSHVQ PTAANLVGFN PCQEDNGRCQ
2360 2370 2380 2390 2400
QLCFALPEQE QPTCACAHGS LLNNGVSCGY GLYEFLVFTT DYTMNSLRLD
2410 2420 2430 2440 2450
PSDHTSPYPT INLGYNVVAL DFDFADKRIF FAQYMGIGRS RIGYVITTVT
2460 2470 2480 2490 2500
GAPAIIADNL NYPQGLAYDW VHKRLYFTDN YNRSVQAMGV DGQNRSLIAH
2510 2520 2530 2540 2550
ANRPLGIIVD PCYGYLYWTD WGSPAKIERA TLGGNFRVPI ISTSLSQPKG
2560 2570 2580 2590 2600
LSIDNEERML YWADASLDKI ERSTLTGESR QVIMRGVQYP YAMTVFQQDI
2610 2620 2630 2640 2650
YWTDWTTRAV YRAGKDDGSG FTVLVQELQY RPNDIHVFAG SKQEACSSPC
2660 2670 2680 2690 2700
QQFNGGCSHV CVPGPSGPEC QCPVSGNWYL ANNGRDCIHD NGNRCQPEQF
2710 2720 2730 2740 2750
TCLNGGCISV RLKCDGYSDC QDNSDELERV CAFHKCSAQD FTCDNGRCVA
2760 2770 2780 2790 2800
LSYVCDYTND CGDNSDELGC PFPTCASATE FTCTNGRCIS AAFVCDGYND
2810 2820 2830 2840 2850
CRDNDTSDEI NCPPRTCPSG QTKCDTTNIC IYASQLCDGY NNCGDNSDEN
2860 2870 2880 2890 2900
PLFCAGRTCS PDQFRCDEGK CIPSYWVCDW VRDCVDGTDE PPSCQDQINT
2910 2920 2930 2940 2950
CHPDQFTCTN GNCIPMSMTC DGNNDCWDNS DEALELQCGE RTCASHQFTC
2960 2970 2980 2990 3000
PPPWRPGHPR CIPLSYVCDG EKDCADAADE LQNCPNRTCH MNEFTCANGL
3010 3020 3030 3040 3050
CILIPFRCDR VNDCGDGSDE LGCSYDTCTS YQFTCQNGAC IPATFTCDGE
3060 3070 3080 3090 3100
ADCLDLSDEA EGMCSTPQPT CAPGEYLCKS GECIDTHKVC NSQKDCSDNS
3110 3120 3130 3140 3150
DEKGCGINEC QDPSVHKCAQ VCTDTLTGYY CSCNAGYHLM PDGKACADLD
3160 3170 3180 3190 3200
ECRDTPAVCS QICENSAGSF HCKCAPGYVR EPDGRTCRQN SAIAPYLLYS
3210 3220 3230 3240 3250
NRYYIRNLTT DGSQLSVVLQ GLSNVVALDF DHYEKRLYWL DAGMVRIERM
3260 3270 3280 3290 3300
RFDGSERETI VDNNVVGAEG LAVDWVGRKL YWVDGYYGSL HVSELDGRFQ
3310 3320 3330 3340 3350
KKLLSGCMGP NATYCFVRPR AVAVNPKYGW LYWTDWGDTA YIGRVGMDGT
3360 3370 3380 3390 3400
KATALITTKL EWPSALTIDY TTNKIFFTDS HLNFLDFADM DGENRHRAIA
3410 3420 3430 3440 3450
GSLPHPFAVT LFEDWVYWTD WNTHTVEKAH KYTGTGRVVM GNNTHRPNDI
3460 3470 3480 3490 3500
HVYHPYRQPR SDNPCATHHL TCSHLCLIGP GGTSATCECP DHFIGISVGF
3510 3520 3530 3540 3550
KIQCVADCSS TQFRCGDNEK CVSIWWKCDG QSDCGDGSDE PLTCPPRYCP
3560 3570 3580 3590 3600
IGQFQCQDGN CTYPGFLCDG HADCRDNSDE DAALCSDHRC AENQFQCKNK
3610 3620 3630 3640 3650
QCIPVSWHCD GIVDCSDGSD EDTDGCAQKT CRPGQFTCAN GVCIPPNYVC
3660 3670 3680 3690 3700
DAQNDCGDGS DEPHEICMGP EYNCDELTEF SCKTNYRCIP TWAVCDGSND
3710 3720 3730 3740 3750
CLDNSDEQNC EALTCDPLGD FRCDNHRCVP IRWKCDGSND CGDGSDERDC
3760 3770 3780 3790 3800
VPRPCSESEY RCDNQQCIPG NWVCDHGNDC GDNSDERDCE LKTCRPGYFQ
3810 3820 3830 3840 3850
CLSGHCIPAA LQCDGRPDCL DISDESSCPT RYPGGRWCPN HQFQCANKLC
3860 3870 3880 3890 3900
VYENWVCDGN NDCGDQSDEE LILCLNITCE MPSRFRCANG YCIYSGNLCN
3910 3920 3930 3940 3950
QKDDCGDGSD EKEDLCREPT LAPCTLQEFK CTNGQCVALP YVCDHNDNCG
3960 3970 3980 3990 4000
DLTDEIGCNF GHDRTCEERL CQHECTNLNR TGFICSCRPG YRVDPDSTFN
4010 4020 4030 4040 4050
CTDINECEVH GTCPQVCKNT KGGYDCECAP GYRKVGNGNQ CEAEGAGPLL
4060 4070 4080 4090 4100
LLPENIRIRK FNLQMEAYHD FLEEQEHIMA LDYDWDHNNT GLSMVYFTVE
4110 4120 4130 4140 4150
GKDNAAGAIK RAYIPTVDDN SNNIAAAVDL GIKYITTPDG IAVDWVGRNL
4160 4170 4180 4190 4200
YWADSRVKRI EVAMLDGRYR KHLVKTDIDH PSAVAVNPRL GMLYWADRGT
4210 4220 4230 4240 4250
AARIEYSWLD GQHRNVLVPD GLGFPTGLSI DYANGDRVYW SDAKESRIES
4260 4270 4280 4290 4300
VLPSGEDRRT ALYIDVRYPF SVSVFEDHIY WSTQEKGEVF RQDKFGRGTK
4310 4320 4330 4340 4350
TKLLTAGPWL TQISVYQQQR YNSIGMKTPC KGICSHLCLL RPGGYTCACP
4360 4370 4380 4390 4400
EGTSFVSGSK TDCDAGFDPP PTMPPPCQCI NGGTCYFDDN KAMCICPPEW
4410 4420 4430 4440 4450
QGDFCEINIF GVVASSVGIA IGVTVLIVLV LGGLVYAAQR KASVMETISH
4460 4470 4480 4490 4500
IMPSMASFRG APYQSSDPSK EEGSDPGPSS KAEPCTAVPM EEAGGKSFEN
4510 4520 4530 4540 4550
PAYAAEGFER PATNAITTAI LVPNGTAMEN IENPLYAEVR VVAEPDPEPD
4560 4570 4580 4590 4600
ASATPANTES VEGAFENPDE ELTPEEPVAD ESLKFEPIPD DNADDNFINP
4610
MFSDPTYPST PADSFT
Length:4,616
Mass (Da):510,520
Last modified:April 12, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD97EE159B034D99
GO

Sequence databases

NCBI Reference Sequences

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RefSeqi
XP_014014128.1, XM_014158653.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
106579098

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
sasa:106579098

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_014014128.1, XM_014158653.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi106579098
KEGGisasa:106579098

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
101886177

Phylogenomic databases

OrthoDBi1606at2759

Family and domain databases

CDDicd00112, LDLa, 36 hits
Gene3Di2.120.10.30, 8 hits
4.10.400.10, 36 hits
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR026823, cEGF
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt
PfamiView protein in Pfam
PF12662, cEGF, 1 hit
PF07645, EGF_CA, 3 hits
PF00057, Ldl_recept_a, 35 hits
PF00058, Ldl_recept_b, 10 hits
PRINTSiPR00261, LDLRECEPTOR
SMARTiView protein in SMART
SM00181, EGF, 23 hits
SM00179, EGF_CA, 8 hits
SM00192, LDLa, 36 hits
SM00135, LY, 36 hits
SUPFAMiSSF57184, SSF57184, 3 hits
SSF57424, SSF57424, 34 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 3 hits
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 5 hits
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 3 hits
PS01209, LDLRA_1, 20 hits
PS50068, LDLRA_2, 36 hits
PS51120, LDLRB, 35 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1S3NF92_SALSA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1S3NF92
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: February 10, 2021
This is version 21 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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