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Entry version 11 (11 Dec 2019)
Sequence version 1 (12 Apr 2017)
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Protein
Submitted name:

serine/threonine-protein kinase WNK1-like isoform X1

Gene

LOC106573365

Organism
Salmo salar (Atlantic salmon)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseImported, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
serine/threonine-protein kinase WNK1-like isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC106573365Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmo salar (Atlantic salmon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8030 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000087266 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini214 – 472Protein kinaseInterPro annotationAdd BLAST259

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 31DisorderedSequence analysisAdd BLAST31
Regioni89 – 122DisorderedSequence analysisAdd BLAST34
Regioni148 – 205DisorderedSequence analysisAdd BLAST58
Regioni561 – 650DisorderedSequence analysisAdd BLAST90
Regioni663 – 688DisorderedSequence analysisAdd BLAST26
Regioni703 – 786DisorderedSequence analysisAdd BLAST84
Regioni1018 – 1042DisorderedSequence analysisAdd BLAST25
Regioni1057 – 1527DisorderedSequence analysisAdd BLAST471
Regioni1560 – 1619DisorderedSequence analysisAdd BLAST60
Regioni1652 – 1769DisorderedSequence analysisAdd BLAST118
Regioni1889 – 1929DisorderedSequence analysisAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 31PolarSequence analysisAdd BLAST15
Compositional biasi94 – 109Pro-richSequence analysisAdd BLAST16
Compositional biasi163 – 205PolyampholyteSequence analysisAdd BLAST43
Compositional biasi561 – 583PolyampholyteSequence analysisAdd BLAST23
Compositional biasi584 – 611PolarSequence analysisAdd BLAST28
Compositional biasi612 – 626Pro-richSequence analysisAdd BLAST15
Compositional biasi627 – 650PolarSequence analysisAdd BLAST24
Compositional biasi720 – 785PolarSequence analysisAdd BLAST66
Compositional biasi1066 – 1111PolarSequence analysisAdd BLAST46
Compositional biasi1135 – 1273PolarSequence analysisAdd BLAST139
Compositional biasi1283 – 1301PolarSequence analysisAdd BLAST19
Compositional biasi1308 – 1328PolyampholyteSequence analysisAdd BLAST21
Compositional biasi1330 – 1350PolarSequence analysisAdd BLAST21
Compositional biasi1395 – 1409PolarSequence analysisAdd BLAST15
Compositional biasi1466 – 1514PolarSequence analysisAdd BLAST49
Compositional biasi1560 – 1604PolarSequence analysisAdd BLAST45
Compositional biasi1677 – 1769PolarSequence analysisAdd BLAST93
Compositional biasi1889 – 1922PolarSequence analysisAdd BLAST34

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K08867

Database of Orthologous Groups

More...
OrthoDBi
27514at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR024678 Kinase_OSR1/WNK_CCT
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12202 OSR1_C, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A1S3MKV7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEKPNDKMK FLAPLSKSGN GNINNGSGSD SLVGERVAVE LRHRHHTMER
60 70 80 90 100
DRCPAEYRPF FRRSVISDSN ATALDLPLPS TIPIFTPIEP PVQDVSHPAG
110 120 130 140 150
PPPTPRPAPR VTVTESEGGE VKVDVSVEQK AAVVQDICDG EAVAQPANRL
160 170 180 190 200
AAQPPSQTTE PGSGDEVKER EEGEEEKEKA RVEAEQREAE KKVQDDIEEA
210 220 230 240 250
ETKAVGTSPD GRFLKFDIEI GRGSFKTVYK GLDTETTVEV AWCELQDRKL
260 270 280 290 300
SKSERQRFKE EAGMLKGLQH PNIVRFYESW EAPVKGRKCI VLVTELMTSG
310 320 330 340 350
TLKTYLKRFK VMKIKVLRSW CRQILKGLHF LHTRAPPIIH RDLKCDNIFI
360 370 380 390 400
TGPTGSVKIG DLGLATLKRS SFAKSVIGTP EFMAPEMYEE KYDESVDVYA
410 420 430 440 450
FGMCMLEMAT SEYPYSECQN AAQIYRRVTS GVKPASFDKV AIPEVKEIIE
460 470 480 490 500
GCIRQNKDER YSIKDLLNHA FFQEETGVRV ELAEEDDGEM EAIKLWLRIE
510 520 530 540 550
DVKKLKGKYK ENEAIEFSFD LRKDVPEDVA QEMVESGYVC EGDHKTMAKA
560 570 580 590 600
IKDRVSLISR KREQRQQVRE EQEKRRLEEE QGQRQQEQLI LQQQSGTEAS
610 620 630 640 650
QPGQQAAPYT QPQPTQQPPQ PNLQTTPDIP PQTAQLGPQG VPYIPQSTGQ
660 670 680 690 700
LPVPVSTQVL AQPESEAPEV DQYPQQTETA NQITDSSSIL PEMHLVQPVV
710 720 730 740 750
SYSSLPSQQP QPEAPYPQAT PPVQTDQSQQ QPQQTMVVPA AQTATVVPGA
760 770 780 790 800
PQQQPQPVGS AVPQSTALPP LQPGAQQIQS WANEPSPPIL SPPINAEHLY
810 820 830 840 850
FLYQAANLSV LQASVSVFQP VSAERSAAGQ TALVPQSVEN CLSNVLSGLS
860 870 880 890 900
DGYEGTSDGR HEGRSMIKRH QQHSVRSHSC HEKTAKAKLI VLNISNMGDR
910 920 930 940 950
VAECQLETHN RKMVTFKFDL DGDNPEEIAR IMVLSKFILE SERKSFIEQV
960 970 980 990 1000
REVIEMPDDK GEGMKEGYAQ PPFTQIVVDD PLQQRDKPTP LSGVAAQVVH
1010 1020 1030 1040 1050
SAGRRFIVSP VPESRLREQF FGPPSANTSF GDEPHPVSLG LSLSAPSSRL
1060 1070 1080 1090 1100
QQAFTEMRET HGERRATSTV PSSQAGLHPT PTTSSTLPHV SVIPSGSSSL
1110 1120 1130 1140 1150
PSSTCQVATG RVSPTPVPAP ATSELIPHPQ PGCQAAPAQI TSPPSAALQH
1160 1170 1180 1190 1200
PQATSSSFPP ASADQMGSSS APVSGAPPSN SGTVTSSEQH LVPILSSQPV
1210 1220 1230 1240 1250
PVSVPVTQPT SSQSQPVPVS VPVTQPTSSQ SQPVPVSVPV TQPTSSQSQP
1260 1270 1280 1290 1300
VPVSVPVTQP TSSQSQSQPV PTFVPVAQPA MAPTQLPPST LASQPSQLQP
1310 1320 1330 1340 1350
GDPDGGESKA PGIDDIHALE KKLRSLFKDT TSADPGNTET TSSSTETISP
1360 1370 1380 1390 1400
PHLAALVPPF NLSLTSGEQG APGPPSNPGQ GLTPAEHAQI HPEQHGQATR
1410 1420 1430 1440 1450
AQAGTPTSEQ LPPFPVPNQS QQPLGSLDGQ LRRAVSPETI PGSSRATMPS
1460 1470 1480 1490 1500
TGFVKLGRFQ VSEAGAGSTP DPSTIASSSS LTPSSSSSSS SSSSSFSSPE
1510 1520 1530 1540 1550
NTLHRSSSLS KGVWSGDSVD GLTSVPTQPA TIGRFQVTAS VTPSPNSVSK
1560 1570 1580 1590 1600
VGRFSVTPAA ANTTAPSGSS LSHQNGPSSS TTSDPCSSAS GVNRGLFNHY
1610 1620 1630 1640 1650
MTSDNEDDSG PEDEAFEREV SRLREKHMIE IQTLHSHHKE EIDALFTRLG
1660 1670 1680 1690 1700
KPRPSAVLSP SVAMAGGRRR AKTKASKSAR SSTQPGPLHS GAQVTGQTSP
1710 1720 1730 1740 1750
ESSPKQTSRP TAGLSEPGSR TSLQNLKLSP SLPSLSTSTM GVSGTSSDSG
1760 1770 1780 1790 1800
ANTSRSQPSG PNMAPALTQS RKGTFTDDLH LLVDNWARDA ISLSHVKKGP
1810 1820 1830 1840 1850
KGTSQGPGHD IPLHIPPQAN MGRKFSAPGH LCPTTHPSTN PSSIPLCPRQ
1860 1870 1880 1890 1900
GSLGTSAQVF GYGPSTYSTP QWAGPTGPCQ VGLLASTQPQ AQYQPQAPSS
1910 1920
ASAPLQQAFH VGATQKPVSN PGGPNLRPT
Length:1,929
Mass (Da):206,557
Last modified:April 12, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i99DDF1B4AB98C390
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1S3MKS1A0A1S3MKS1_SALSA
serine/threonine-protein kinase WNK...
LOC106573365
1,928Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1S3ML42A0A1S3ML42_SALSA
serine/threonine-protein kinase WNK...
LOC106573365
1,896Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1S3ML64A0A1S3ML64_SALSA
serine/threonine-protein kinase WNK...
LOC106573365
1,895Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1S3MLX8A0A1S3MLX8_SALSA
serine/threonine-protein kinase WNK...
LOC106573365
1,666Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_014003827.1, XM_014148352.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
106573365

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sasa:106573365

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_014003827.1, XM_014148352.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi106573365
KEGGisasa:106573365

Phylogenomic databases

KOiK08867
OrthoDBi27514at2759

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR024678 Kinase_OSR1/WNK_CCT
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF12202 OSR1_C, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1S3MKV7_SALSA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1S3MKV7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: December 11, 2019
This is version 11 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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