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Entry version 10 (16 Jan 2019)
Sequence version 1 (12 Apr 2017)
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Protein
Submitted name:

obscurin isoform X12

Gene

obscn

Organism
Salmo salar (Atlantic salmon)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
obscurin isoform X12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:obscnImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmo salar (Atlantic salmon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8030 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000087266 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 96Ig-likeInterPro annotationAdd BLAST87
Domaini110 – 198Ig-likeInterPro annotationAdd BLAST89
Domaini273 – 360Ig-likeInterPro annotationAdd BLAST88
Domaini365 – 448Ig-likeInterPro annotationAdd BLAST84
Domaini549 – 645Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini733 – 821Ig-likeInterPro annotationAdd BLAST89
Domaini846 – 910Ig-likeInterPro annotationAdd BLAST65
Domaini914 – 1015Ig-likeInterPro annotationAdd BLAST102
Domaini1029 – 1100Ig-likeInterPro annotationAdd BLAST72
Domaini1121 – 1199Ig-likeInterPro annotationAdd BLAST79
Domaini1213 – 1270Ig-likeInterPro annotationAdd BLAST58
Domaini1305 – 1364Ig-likeInterPro annotationAdd BLAST60
Domaini1373 – 1468Ig-likeInterPro annotationAdd BLAST96
Domaini1483 – 1557Ig-likeInterPro annotationAdd BLAST75
Domaini1562 – 1646Ig-likeInterPro annotationAdd BLAST85
Domaini1650 – 1826Ig-likeInterPro annotationAdd BLAST177
Domaini1921 – 2006Ig-likeInterPro annotationAdd BLAST86
Domaini2101 – 2185Ig-likeInterPro annotationAdd BLAST85
Domaini2189 – 2274Ig-likeInterPro annotationAdd BLAST86
Domaini2279 – 2363Ig-likeInterPro annotationAdd BLAST85
Domaini2368 – 2440Ig-likeInterPro annotationAdd BLAST73
Domaini2457 – 2541Ig-likeInterPro annotationAdd BLAST85
Domaini2546 – 2630Ig-likeInterPro annotationAdd BLAST85
Domaini2635 – 2719Ig-likeInterPro annotationAdd BLAST85
Domaini2724 – 2808Ig-likeInterPro annotationAdd BLAST85
Domaini2813 – 2897Ig-likeInterPro annotationAdd BLAST85
Domaini2962 – 3053Ig-likeInterPro annotationAdd BLAST92
Domaini3141 – 3224Ig-likeInterPro annotationAdd BLAST84
Domaini3318 – 3401Ig-likeInterPro annotationAdd BLAST84
Domaini3408 – 3492Ig-likeInterPro annotationAdd BLAST85
Domaini3588 – 3664Ig-likeInterPro annotationAdd BLAST77
Domaini3863 – 3958Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini3958 – 4041Ig-likeInterPro annotationAdd BLAST84
Domaini4280 – 4368Ig-likeInterPro annotationAdd BLAST89
Domaini4526 – 4615Ig-likeInterPro annotationAdd BLAST90
Domaini4660 – 4749Ig-likeInterPro annotationAdd BLAST90
Domaini4764 – 4867Ig-likeInterPro annotationAdd BLAST104
Domaini4972 – 5039SH3InterPro annotationAdd BLAST68
Domaini5063 – 5247DHInterPro annotationAdd BLAST185
Domaini5265 – 5374PHInterPro annotationAdd BLAST110
Domaini5384 – 5473Ig-likeInterPro annotationAdd BLAST90
Domaini5478 – 5568Ig-likeInterPro annotationAdd BLAST91

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

RepeatSAAS annotation, SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
349at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 2 hits
cd12025 SH3_Obscurin_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.60.40.10, 49 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR000048 IQ_motif_EF-hand-BS
IPR035526 Obscurin_SH3
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 40 hits
PF00612 IQ, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 45 hits
SM00408 IGc2, 38 hits
SM00406 IGv, 18 hits
SM00015 IQ, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit
SSF48726 SSF48726, 46 hits
SSF49265 SSF49265, 2 hits
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010 DH_2, 1 hit
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 37 hits
PS50096 IQ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 34 potential isoforms that are computationally mapped.Show allAlign All

A0A1S3LZH0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDQNLFGGAP RFLTRPKAFA VCVGKDATLS CTIVGNPTPL ITWEKEKLRL
60 70 80 90 100
TSGGRFKMVD DGDVYRLTIY DLTLEDSGQY MCRAKNNVGE AYACVTLHVG
110 120 130 140 150
LPQEMVERAP VFMVKPTSAR VGLGGDVVFH CRVAAYPEPK FDWEKDGRYL
160 170 180 190 200
AETNRIKVTS DSDSSSLRIQ SVRSLDSGTY TCRAQNSVGR SNSAATLVVD
210 220 230 240 250
TQDSRHLGKD KSTSLLSHLQ KRKEGISIYC TAETSSSTYN STTTSSTATT
260 270 280 290 300
MVTDGLSLLG LDHSSAALVS HLPKGVFTRT CTVTEGKHAK LSCFVTGHPK
310 320 330 340 350
PHIIWRKDGG NIGEGRRQIM YEDQAENFIL KILYCKQRDN GLYTCNASNM
360 370 380 390 400
AGHTYSAVLV IVKEPKVPFR RKLQDVEVQE KMTATLLCEV PISTTQASWF
410 420 430 440 450
MEETRLEDCS KYRMEEEGTM RRLTIHNVTT NDDAVYICEM KEGSRTVAEL
460 470 480 490 500
TVLGNITKKL PRRTVVPVSD TVIFCVELEH PCSDAYWTRN AERLKPDTRI
510 520 530 540 550
LIACTLRQYT LTISHCQADD SGEVAFMAGD CKTSTRFSVT AARKHPPDPP
560 570 580 590 600
IDVVVRNKTD SSITLHWSPP DSDRPVPIKG YMVERRKVGA QTWQRCNGME
610 620 630 640 650
ISPFTEITIQ NFTEEASYQF RISAVNNYGQ SQYLEVPGTF YLEPSAEVKT
660 670 680 690 700
GLMNSTAISG EEASLSVDLS AVCSGFWSIN GRLLRSGGDY LITRQKTTHT
710 720 730 740 750
LMIRTVLMEM NGAVVKFVGG GSESTCILKV KAPPIRFTSK SAHTEVVTCS
760 770 780 790 800
AQSSAQLTTE VSDYHAQVVW MKNGRELKMG KKYECITTDH KRILMVHNVT
810 820 830 840 850
EEDTGIYECV LNEDRMSLKL SLKDEAKFLN KPRGPMGVAP ALSGHLELNC
860 870 880 890 900
EVSSASGVVV WRKDQTVVIE DQRTTIVSKG TQRRLVIKNA KKSDEGHYSC
910 920 930 940 950
ETAEDKVTFQ VKIKEVQQAA FTNKDSVQKE VRATLSQKAT LSCEVSDTKT
960 970 980 990 1000
EVKWYKDGKQ IIASKTVSME TKGKSRLLVI DKMEKKDAGE YTCEARAEKL
1010 1020 1030 1040 1050
VFKIHVSEAQ QAAFTNKDSV QKEVKAILSQ KATLSCEVSD TKTEVKWYKD
1060 1070 1080 1090 1100
GKLLTSSKTV SMETKGKTRQ LVIEKVEKKD AGQYTCEVGA EKLVYEIQVT
1110 1120 1130 1140 1150
EAQAAFTNKD SVQKEVKAAL SQKATLSCEV SDTKTEVKWY KDGKLLTSSK
1160 1170 1180 1190 1200
TVSMETKGKT RQLVIEKVEK KDAGQYTCEV GAEKLVFKIQ VTETQAAFTN
1210 1220 1230 1240 1250
KDSVQKEVRA ILSQKATLSC DVSDTKTEVK WYKDGKLLTS SKTVSMETKG
1260 1270 1280 1290 1300
KTRQLVIEKV EKKDAGQYTC EFGAEKLAFK IQVTEVQAAF TNKDSVQKEV
1310 1320 1330 1340 1350
RAILSQKATL SCEVSDTKTE VKWYKDGKLL TSSKTVSMET KGKTRQLVIE
1360 1370 1380 1390 1400
KVEKKDAGQY TCEVGAEKLV FKIQVTEIQA AFTNKESVKK EVKAALSQKT
1410 1420 1430 1440 1450
TLSCEVSDTK TEVKWYKDGK LLTSSKTVSM ETKGKTRQLV IEKVEKKDAG
1460 1470 1480 1490 1500
QYTCEVGAEK LVYKIQVTES SAKFKKSAVK DVCSVQASEK IVLTTELTSE
1510 1520 1530 1540 1550
SASVKWFRDG VELKEGTKYE MKREGHSRTL IVKSTEVKDS GTYSCHTDDD
1560 1570 1580 1590 1600
KLEFKVQVKH TPLKFVVQLQ PVATELGVTL NLTCELNQAS GDVLWRHNSR
1610 1620 1630 1640 1650
EVKPGGRFCV SADGAKRVLT VTGMTKEDEG EYICECKDDK TSAKVSTNAP
1660 1670 1680 1690 1700
RLVNLTSKLS SIAAVEGKDV IFKCSVTPAD VKVKWFRNNV PITAGPKYKI
1710 1720 1730 1740 1750
EHRATSHSLT ITSVSQEDAG EISMAAEGKT CSATLQVQLE PVMFKKKLQN
1760 1770 1780 1790 1800
VTTVEDQKGV KLEVELSRPS KEVRWMKNSV VLQPGDNMDI RVDGAKQTLV
1810 1820 1830 1840 1850
FKSVTTADRG YYSCETLDDK TQAKLTVDVQ KIEVVKGLLA EVKANEKETV
1860 1870 1880 1890 1900
TLEVELSQAD VEGSWTKSGA KLKAGSNCRI TALGKKACPL HCPNSRWRTQ
1910 1920 1930 1940 1950
ERLSFQAEGV KSSGKLIVAE PAAMISRPMK DVKAPEKEKA TLECEVSRTN
1960 1970 1980 1990 2000
AEVKWFKGDT ELKPGKNFGI HSQGRTRSLL IHKCSKEDEG TYVCRTSDDN
2010 2020 2030 2040 2050
TSAKLTVHAR DIKIVKKLED VEVMEKESAS FLCEISHDEV ACQWFKGDTK
2060 2070 2080 2090 2100
LKVGDNIKMR QEGKIYVLLI KSVTPEDVAE IKFTAEKASS TAKLTVKGKA
2110 2120 2130 2140 2150
QSVSRELQSV SVVSGEDAVF TCEVTQNSAT VQWAKDGKDI RKSEKYNISK
2160 2170 2180 2190 2200
EERVMKLTVR SVTVQDSGEY SCEVIGGATT KAKLVIKEPV HKFTKELKDS
2210 2220 2230 2240 2250
EAEEKGSVTL QCETAQPASK ATWSKGGIEL KAGGRCEMTQ KETVLTLTIK
2260 2270 2280 2290 2300
QLEEKDSGTY TCDVGTAKMT AKVTVKALPA SFKQKLKNQQ ATEGENATLC
2310 2320 2330 2340 2350
CVLAKPGATV QWKKGTENLK AGNKYEIKQK DAGCELQIKH LKVEDSGEYS
2360 2370 2380 2390 2400
CECGDQRTTA TIKVNALPVT YKHKLESQEA GEGGSVTLHC ELSKPGVPVE
2410 2420 2430 2440 2450
WRKGTQVLKS GEKYQMKQKE SVSELLISKV VPEDSGDYSC VCGDQKTIAS
2460 2470 2480 2490 2500
LKIKAQPVTF KHKLESQKAE EGGSVTLHCE LSKPGVPVEW RKGTQVLKSG
2510 2520 2530 2540 2550
EKYQMKQKES VSELLISKVV TEDSGDYSCV CGDQKTTASL KIKAQPVTFK
2560 2570 2580 2590 2600
QKLESQKAEE GGSVTLHCEL SKPGVPVEWR KGTQVLKSGE KYQMKQKESV
2610 2620 2630 2640 2650
SELLISKVVP EDSGDYSCVC GDQKTTASLK IKAQPVTFKY KLQRQEAEEG
2660 2670 2680 2690 2700
GSVTLHCELS KPGVPVEWRK GTQVLKSGEK YQMKQKESVS ELLISKVVPE
2710 2720 2730 2740 2750
DSGDYSCVCG DQKTTASLKI KALPATFKHD LESQEVEEGG SVTLHCELSK
2760 2770 2780 2790 2800
PGLPVEWKKG TQVLKSGDKY QMKQKDCSVK LQICDLKPED TGNYHCSTGD
2810 2820 2830 2840 2850
LESSAYLKVN ALPVIFTKDL QSQEAEEGGS VTLHCEVSKP GVPVEWTKGE
2860 2870 2880 2890 2900
VGLCPCAKYE IVQEGHSARL VIHSLDSEDS GSYTCDSGDR KTTAKLSVKG
2910 2920 2930 2940 2950
RLRENSSGFS CVCCRERKSN FPTCIIHILW FGGTILPSKS FSISPLPTYI
2960 2970 2980 2990 3000
IPTPLLLSTA LPVYFKTRLQ NLEWDAGEIA ILRCEITNPG ASVVWSRGDR
3010 3020 3030 3040 3050
VLESNNKYQL KQEGAIVKLI IYNLQGADSG EYICDTGYQK TSSMLTVQEL
3060 3070 3080 3090 3100
EVTIVKVLNS CSVREGEDVH FECHLSHEDA KGVQWKLADV PLQNNEMNLI
3110 3120 3130 3140 3150
RSQGKVHSLT LRGVTQADSA TVAFTVGHHT STASLTVRGA PVVFKKELES
3160 3170 3180 3190 3200
QEAVEGGSVS LTCEISAEGK VTWRRGSVLL TQGEKYSMEH TGSTYILMVH
3210 3220 3230 3240 3250
KLKVEDAGEY TCDTGDKQST ATLTVKESVR ITRELHDITV TTGQDAVFAC
3260 3270 3280 3290 3300
ELSQEGVTNG EWWLGDNLLQ NNDLNQITFQ GRVHRLTLQM VTTDESGDVA
3310 3320 3330 3340 3350
FVVGEEKTVA CLLVEEKPKV LILEKPHDTV ALEGETVTLS CTVSDPTATI
3360 3370 3380 3390 3400
TWSRNDVAIK AGLKYDLRKN GALMQLRIHN LEMEDSGTYC CDTGDAQCTV
3410 3420 3430 3440 3450
TLTVEGAPAF FLKELKNKEA QEGDDITLRC ELSKACTQVE WRKGGMVLQA
3460 3470 3480 3490 3500
GKKYEMRQEG CVQELRIRNL EPDDNGYYTC DAGDQLTTAS VAVQEAEVLI
3510 3520 3530 3540 3550
VCGLKSTDVF LGEWATFSCQ LSRGVRPGEV QWWLDGTLLQ DSPSSEIGLS
3560 3570 3580 3590 3600
QGHVHTLTLK DLAPDASGTV TFKACSLVSY AKLLVKDPTV EVVSEMQDLR
3610 3620 3630 3640 3650
VAEDKPAEFI CQYSRPVQAQ WKRDGRPLQP DGQRVVVEQD WTVARLYISH
3660 3670 3680 3690 3700
VSTEDRGRYS CEAEGTCVVA LLEVEAKPIE ILQGLENMDT IDGGEALFEC
3710 3720 3730 3740 3750
SISRCEIKDC RWLIGGKPVK ESPTTEIVSF ESGRRHLLLL KDLHVGDSCK
3760 3770 3780 3790 3800
VTFQAGTATT SAMLNVKGWQ LDVVSGLEDK VAVVGETLEF SCMLTEPVPE
3810 3820 3830 3840 3850
AEVAWYSNGA ELKADDTWGM RADGCSYHLV LRQAPAMPPQ EITFAARDAI
3860 3870 3880 3890 3900
SMAKLTIITV PDPPEDPELV SKSKQAVTLS WFTPLSDGGS PILGYRVEMR
3910 3920 3930 3940 3950
LADSVLWLPC HAEPVCNTEF SVDNLIPGSG YRFRVAAINR AGTGEPVQLP
3960 3970 3980 3990 4000
QSVQLEAPVT VTQQLACPDL QEGKMARVEC ELSAEGSSVT WLKDNKELEY
4010 4020 4030 4040 4050
GVKYQVTTEG KTQVLLIKDF ESADQGVYTC VASDEAESSL NLNLPKGGDG
4060 4070 4080 4090 4100
VQLEEGAQPS LPPEAASEGD VHALWEDLAK KRRMSREPTL DSISELPDEE
4110 4120 4130 4140 4150
DKEPKTPKGP VKEKKAPEMV GVKALENEKV DVKAPEKEKV EVKAPEKEKV
4160 4170 4180 4190 4200
KEKEKVIEHV IVPKKKVLEP NLYTSSEDES RPPTLVSYLK KSSKSSLSVC
4210 4220 4230 4240 4250
DQTESISTEK FYAQFKLKEE TTVQQTSVQQ TSSSVQQITA QTTDITKVGD
4260 4270 4280 4290 4300
EEDEEKGLLD AAVKIQAAFK GYKARKDMRP VFKDVFKDQT KEPNGTIHLE
4310 4320 4330 4340 4350
CVAEGKPEKV RWLKDGEHLA DGKHHHIDIY NDGTCSLVIT AVTTKDTGVY
4360 4370 4380 4390 4400
TCEVTNKFGV TTHSGKVTVG SAREASGRRP LTMGYSADSE AESSSAESEM
4410 4420 4430 4440 4450
DESLRQASKR LRRLLRTRLP ATSEEESFVS CDDEAELQAP DPKSYREDER
4460 4470 4480 4490 4500
YIYIRFDKRS EAQVASQRFK EMFTAQGVPV ETTIQEAGPL KVELRIMKMG
4510 4520 4530 4540 4550
YTQDGSATPT QEKQLPAFMT GAPAAPVFLT ELQSQDVPDG YPVSFDCVVI
4560 4570 4580 4590 4600
GKPPPSVRWF KDGKLLEEND HYMINEDQEG CHQLIITTVL PSDMGVYRCM
4610 4620 4630 4640 4650
AENTSGIAAT KAELRVDMSC SSDYDTAADA TETGSYISAK GYMSRETEAF
4660 4670 4680 4690 4700
ESVVEDEQMP QVLDELHDVH VSPGSPIAKM QLKVKGFPSP RVYWFKDGHP
4710 4720 4730 4740 4750
LRSSDRILLL DKRDIHSLEV LEVKREDTGE YSAYISNAAG TAYSSARLLV
4760 4770 4780 4790 4800
LGPGELTPVE KHDPKVPLVP PRFLERFSNR KVKQGASVTM SVRVEGSPTP
4810 4820 4830 4840 4850
MVTWLKEESA EDVLWIKPDT KGYKVASSGR QHSLILMDVG SKHAGTYTCI
4860 4870 4880 4890 4900
ATNKAGQSIC TAQFEVEDAP QPKEETTIPL GITISPPDED VGRGKMQYLG
4910 4920 4930 4940 4950
EVGSEEFLMK LTSQITEMVS AKISQASLRV PGGDSDDETK TPSASPHHGR
4960 4970 4980 4990 5000
SRPGSILADS SSESDDPDAR GEMFDIYVAT ADYNPTIPNK DTISLKEGQY
5010 5020 5030 5040 5050
VEVLDSAHPL KWLVRTKPTK TTPSRQGWVS PAYLDKKLKL SDVAGDIPEG
5060 5070 5080 5090 5100
GGEEVSEGEY KKRLLQLIQD MINSEAEFVK EMDFFTSHHV KQVESPDAPS
5110 5120 5130 5140 5150
DITSQKEAIF RNINEIKAFH SESMLPKLIH CDTDDDVAMR FLRSSEGFEK
5160 5170 5180 5190 5200
YLQYLVGQQK AEAAISDKTV HRFFKEYTDK EQASADPAEG PVLSINAYLQ
5210 5220 5230 5240 5250
KPLDRIQKYK ALLKELIRNK ARNGQNCCLL EEAYAMVSSL PQRSENTHHV
5260 5270 5280 5290 5300
SMIENYPATL DVLGEPIRQG PFMVWEGAPG VRSSSRGHHR HAFLFKNYVI
5310 5320 5330 5340 5350
ICKSKRDTNT DTQGYVFKNM MKLNNIDVNE TVEGDDRAFE IWHEREDSVR
5360 5370 5380 5390 5400
KYTLQARTVI IKNSWLRDLR ELQQRYTMPA WSMPDFDELL ADCTAELRQT
5410 5420 5430 5440 5450
VKLACKVTGV PKPVVTWYKD GRAVEADPHH IIIEDPDGSC TLILDNMTAD
5460 5470 5480 5490 5500
DSGQYMCFAT STAGNASTLG KITVQVPPRF VNKMRNAVLI VGEDAQFSCT
5510 5520 5530 5540 5550
IQSAPRPKIR WFKEGRLLTD QEKYQTYTES RSGVLVLVIK GPTERDLGHY
5560 5570 5580 5590 5600
ECELSNRLGS AKCAVDLCLP SAVARRGEQA ITIEVTEQET KTPKKTIIIE
5610 5620 5630 5640 5650
ETITTVVKNT RMKRRGVSPS GFNRSETTTP DLPTTPTGTA RQRRQVSASR
5660 5670 5680 5690 5700
KTTIPTLYVT EPEGGSGARA AENRWVEVEE IIEYKVNKSP RLSRRRGVSP
5710 5720 5730 5740 5750
AGSERANTPS FTRPQRSPNP NTNNSNNKLV ELQNCSELEG AQPITWDDDE
5760 5770 5780 5790 5800
EDENVAGSEV TPGLSEEACE VSSVLIPNDH EHDEAWLEEQ QEAFVTEPDD
5810 5820 5830 5840 5850
DDNMEPPRKL EPKTLTQDGR VLTLEDLEDY VPREGETYGS SNTRPSPPER
5860 5870 5880 5890 5900
PCEISVLQRE IRGSVVGQPV LLNVGRPVVV PRGRRSPGFF SRFREYLSGS
5910 5920 5930 5940 5950
MFSLAGPHHH PSRGQSRSES EIPIQVSHAK QEVKLAYCSE VQRMEGGQQR
5960 5970
YKTKVYTSVG KPVTLQISQN RYQNQ
Length:5,975
Mass (Da):661,711
Last modified:April 12, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD92B4A77526FE2DD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 34 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1S3LZ15A0A1S3LZ15_SALSA
obscurin isoform X1
obscn
6,123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1S3LZH5A0A1S3LZH5_SALSA
obscurin isoform X17
obscn
5,942Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1S3LZJ5A0A1S3LZJ5_SALSA
obscurin isoform X31
obscn
5,651Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1S3LZG4A0A1S3LZG4_SALSA
obscurin isoform X8
obscn
6,034Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1S3LYW6A0A1S3LYW6_SALSA
obscurin isoform X30
obscn
5,674Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1S3LZJ1A0A1S3LZJ1_SALSA
obscurin isoform X26
obscn
5,741Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1S3LZ27A0A1S3LZ27_SALSA
obscurin isoform X10
obscn
6,031Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1S3LZ00A0A1S3LZ00_SALSA
obscurin isoform X18
obscn
5,939Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1S3LZ43A0A1S3LZ43_SALSA
obscurin isoform X23
obscn
5,770Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1S3LYW3A0A1S3LYW3_SALSA
obscurin isoform X24
obscn
5,767Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

NCBI Reference Sequences

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RefSeqi
XP_013996084.1, XM_014140609.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
106569344

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_013996084.1, XM_014140609.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi106569344

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84033

Phylogenomic databases

OrthoDBi349at2759

Family and domain databases

CDDicd00063 FN3, 2 hits
cd12025 SH3_Obscurin_like, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.60.40.10, 49 hits
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR000048 IQ_motif_EF-hand-BS
IPR035526 Obscurin_SH3
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 40 hits
PF00612 IQ, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 45 hits
SM00408 IGc2, 38 hits
SM00406 IGv, 18 hits
SM00015 IQ, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF48726 SSF48726, 46 hits
SSF49265 SSF49265, 2 hits
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 37 hits
PS50096 IQ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1S3LZH0_SALSA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1S3LZH0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: January 16, 2019
This is version 10 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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